Insulin resistance in non-alcoholic steatohepatitis

Cömert, Bilgin; Mas, Mehmet Refik; Erdem, Hakan; Di̇nç, Ayhan; Sağlamkaya, Uğur; Cigerim, M.; Kuzhan, Okan; Ünal, Tuğrul Cem; Kocabalkan, Fikri

doi:10.1016/s1590-8658(01)80091-8

Cited by 46 publications

(30 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…NAFLD has been strongly associated with both hepatic and adipose tissue insulin resistance (Seppala-Lindroos et al, 2002;Bugianesi et al, 2005). Previous studies found that patients with NAFLD presented reduced insulin-mediated glucose consumption and an impaired ability of insulin to suppress endogenous glucose production (Comert et al, 2001;Marchesini, et al, 2001a). Subjects with NAFLD also presented a blunted inhibition of fatty acid oxidation (Utzschneider and Kahn, 2006).…”

Section: Discussionmentioning

confidence: 99%

Nonalcoholic fatty liver disease is associated with insulin resistance in a young Hispanic population

Pérez

Gonzáles

Olarte

et al. 2011

Preventive Medicine

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Nonalcoholic fatty liver disease is associated with insulin resistance in a young Hispanic population

Pérez

Gonzáles

Olarte

et al. 2011

Preventive Medicine

View full text Add to dashboard Cite

“…18,19 The glucose clamp technique was first used by Comert et al, 20 and subsequent studies showed that the increased IR of NAFLD also includes defective insulin-mediated suppression of lipolysis, [21][22][23] similar to that observed in type 2 diabetes (T2DM). IR is accompanied by higher total insulin secretion and normal hepatic insulin extraction 24 and predicts the presence of more severe disease.…”

Section: Insulin Resistancementioning

confidence: 97%

Insulin Resistance: A Metabolic Pathway to Chronic Liver Disease *

2005

View full text Add to dashboard Cite

Insulin resistance (IR) is the pathophysiological hallmark of nonalcoholic fatty liver disease (NAFLD), one of the most common causes of chronic liver disease in Western countries. We review the definition of IR, the methods for the quantitative assessment of insulin action, the pathophysiology of IR, and the role of IR in the pathogenesis of chronic liver disease. Increased free fatty acid flux from adipose tissue to nonadipose organs, a result of abnormal fat metabolism, leads to hepatic triglyceride accumulation and contributes to impaired glucose metabolism and insulin sensitivity in muscle and in the liver. Several factors secreted or expressed in the adipocyte contribute to the onset of a proinflammatory state, which may be limited to the liver or more extensively expressed throughout the body. IR is the common characteristic of the metabolic syndrome and its related features. It is a systemic disease affecting the nervous system, muscles, pancreas, kidney, heart, and immune system, in addition to the liver. A complex interaction between genes and the environment favors or enhances IR and the phenotypic expression of NAFLD in individual patients. Advanced fibrotic liver disease is associated with multiple features of the metabolic syndrome, and the risk of progressive liver disease should not be underestimated in individuals with metabolic disorders. Finally, the ability of insulin-sensitizing, pharmacological agents to treat NAFLD by reducing IR in the liver (metformin) and in the periphery (thiazolidinediones) are discussed. (HEPATOLOGY 2005;42:987-1000.)

show abstract

“…Both tests have been validated against the gold standard for the measurement of insulin resistance, the euglycemic hyperinsulinemic clamp technique, which was recently used in 3 studies of NASH patients with very similar results. [15][16][17] Because of its simplicity, the HOMA method used by Chitturi et al is suitable for large epidemiologic studies but provides a measure that is, at best, semiquantitative. The HOMA calculation had been previously used in the general population of patients with nonalcoholic fatty liver disease with similar results.…”

mentioning

confidence: 99%