Insulin resistance, β-cell function, and glucose tolerance in Brazilian adolescents with obesity or risk factors for type 2 diabetes mellitus

Silva, Regina Cintra Querino da; Miranda, Walkíria L.; Chacra, Antônio Roberto; Dib, Sérgio Atala

doi:10.1016/j.jdiacomp.2005.11.006

Cited by 16 publications

(14 citation statements)

References 40 publications

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“…[29][30][31][32][33] It should be noted that weight, WC, TGs, and dyslipidemia are risk factors leading to IR in FHD + subjects in our study, which was consistent with the study suggesting that Brazilian adolescents with two or more risk factors-family history of T2DM, obesity, hypertension, dyslipidemia, or polycystic ovary syndrome-for the development of T2DM have higher IR and lower insulin sensitivity. 34 So it is important to prevent these risk factors in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Impact of Family History of Diabetes onβ-Cell Function and Insulin Resistance Among Chinese with Normal Glucose Tolerance

Chen

et al. 2012

Diabetes Technology & Therapeutics

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Section: Discussionmentioning

confidence: 99%

Impact of Family History of Diabetes onβ-Cell Function and Insulin Resistance Among Chinese with Normal Glucose Tolerance

Chen

et al. 2012

Diabetes Technology & Therapeutics

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“…Similar observation has also been in Indians compared with Chinese and Creoles living in Mauritius, and in Brazilians who were at risk for diabetes. [2728] The importance of HOMA-S, as an indicator of beta-cell function, is the detection of subjects with high risk of development of T2D as decreased beta-cell function is evident when fasting plasma glucose concentration is still well within the normal range. [17]…”

Section: Discussionmentioning

confidence: 99%

Study of beta-cell function (by HOMA model) in metabolic syndrome

Garg

Dutta

Mahalle

2011

Indian J Endocr Metab

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Introduction:The clustering of cardiovascular risk factors is termed the metabolic syndrome (MS), which strongly predict risk of diabetes and cardiovascular disease. Many studies implicate insulin resistance (IR) in the development of diabetes, but ignore the contribution of beta-cell dysfunction. Hence, we studied beta-cell function, as assessed by HOMA model, in subjects with MS.Materials and Methods:We studied 50 subjects with MS diagnosed by IDF criteria and 24 healthy age- and sex-matched controls. Clinical evaluation included anthropometry, body fat analysis by bioimpedance, biochemical, and insulin measurement. IR and secretion were calculated by HOMA model.Results:Subjects with MS had more IR (HOMA-IR) than controls (3.35 ± 3.14 vs. 1.76 ± 0.53, P = 0.029) and secreted less insulin (HOMA-S) than controls (66.80 ± 69.66 vs. 144.27 ± 101.61, P = 0.0003), although plasma insulin levels were comparable in both groups (10.7 ± 10.2 vs. 8.2 ± 2.38, P = 0.44). HOMA-IR and HOMA-S were related with number of metabolic abnormalities. HOMA-IR was positively associated with body mass index, waist hip ratio, body fat mass, and percent body fat. HOMA-S was negatively associated with waist hip ratio, fasting plasma glucose and total cholesterol and positively with basal metabolic rate. Percent body fat was an independent predictor of HOMA-IR and waist hip ratio of HOMA-S in multiple regression analysis.Conclusions:Subjects with MS have increased IR and decreased insulin secretion compared with healthy controls. Lifestyle measures have been shown to improve IR, insulin secretion, and various components and effects of MS. Hence, there is an urgent need for public health measures to prevent ongoing epidemic of diabetes and cardiovascular disease.

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“…Out of 19 studies, 14 were cross-sectional studies using children and adolescents in school settings and primary care clinics (Brickman et al, 2010;Caceres et al, 2008;Chang et al, 2008;Guran, Turan, Akcay, & Bereket, 2007;Ice et al, 2009;Kobaissi et al, 2004;Kong et al, 2007Kong et al, , 2010Peterson et al, 2010;Silva et al, 2007;Stoddart et al, 2002;Stuart et al, 1994;Yamazaki et al, 2003) and 5 studies were retrospective nonexperimental studies using chart review from primary clinics…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Is Acanthosis Nigricans a Reliable Indicator for Risk of Type 2 Diabetes in Obese Children and Adolescents?

Abraham

Rozmus

2011

The Journal of School Nursing

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Obesity and type 2 diabetes is becoming a major health problem affecting children and adolescents in the United States. This article reviews the current literature examining the association between the presence of acanthosis nigricans (AN) and risk for developing type 2 diabetes mellitus (T2DM) in obese children and adolescents. Ethnicity, family history of diabetes, and emergence of obesity are contributing factors for development of hyperinsulinemia, and insulin resistance, and ensuing visible changes on skin which is known as the AN. The purpose of this review was to assess the validity of AN as an early indicator of T2DM. Nineteen articles that were published from 1994 to 2010 were included for this review and reported an association between AN, hyperinsulinemia, and hyperglycemia. Nurses and advanced nurse practitioners working with children and adolescents have a tremendous role in identifying the risk factors, counseling, role modeling, and referring them to available community resources to promote healthy living. Early initiatives focusing on lifestyle changes may halt the progress, chronicity, and burden of T2DM in children and adolescents.

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Insulin resistance, β-cell function, and glucose tolerance in Brazilian adolescents with obesity or risk factors for type 2 diabetes mellitus

Cited by 16 publications

References 40 publications

Impact of Family History of Diabetes onβ-Cell Function and Insulin Resistance Among Chinese with Normal Glucose Tolerance

Impact of Family History of Diabetes onβ-Cell Function and Insulin Resistance Among Chinese with Normal Glucose Tolerance

Study of beta-cell function (by HOMA model) in metabolic syndrome

Is Acanthosis Nigricans a Reliable Indicator for Risk of Type 2 Diabetes in Obese Children and Adolescents?

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