Insulin reverses haemodynamic changes and pulmonary oedema in children stung by the Indian red scorpion<i>Mesobuthus tamulus concanesis</i>, Pocock

Murthy, K. Radha Krishna; Shenoi, Ramakrishna; Vaidyanathan, P R; Kelkar, Kumar; Sharma, Nisha; Birewar, N; Rao, Seema; Mehta, Meenakshi

doi:10.1080/00034983.1991.11812621

Cited by 45 publications

(12 citation statements)

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“…Prasozin, an α 1 adrenergic receptor blocker, can only block the increased adrenergic activity seen after envenomation at the postsynaptic sites, but it cannot reverse the underlying pathology generated by kinins or other mediators. Contrarily, there are reports of the successful use of insulin9 10 in patients stung by scorpions, and these reports do not find a place in the discussions of Karnad1 or Bawaskar 5. Therefore, we feel that insulin still has a place as a therapeutic agent in the treatment of scorpion toxicity unless disproved otherwise.…”

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confidence: 85%

On the management of scorpion stings

Deshpande

2000

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confidence: 85%

On the management of scorpion stings

Deshpande

2000

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“…In experimental animals, insulin has been shown to correct metabolic and cardiac abnormalities (Murthy et al 1990), 2-deoxyglucose (increases insulin sensitivity) has been shown to reduce cardiopulmonary abnormalities (Choudhry et al 2011), and aprotinin (a kinin inhibitor) has been shown to reverse cardiac abnormalities (Pandey and Deshpande 2004). Strong) In envenomed child patients, insulin/glucose has been demonstrated to normalize blood pressure and reverse pulmonary edema (Murthy et al 1991). 1 The Indian Red Scorpion, Hottentotta tamulus.…”

Section: Pathophysiology and Clinical Aspectsmentioning

confidence: 99%

Scorpion Venoms

2015

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In recent years, the field of toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast-developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, diabetes, chronic pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever-growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to toxinology. Composed of 11 volumes, Toxinology provides comprehensive and authoritative coverage of the main areas in toxinology, from fundamental concepts to new developments and applications in the field. Each volume comprises a focused and carefully chosen collection of contributions from leading names in the subject.

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“…In envenomed child patients, insulin/glucose has been demonstrated to normalize blood pressure and reverse pulmonary edema (Murthy et al 1991). Vasodilators, including captopril and nifedipine, have been used to correct both venom-induced hyper-and hypotension (Krishnan et al 2007), although the use of captopril, an ACE inhibitor, has been questioned since it has been shown that captopril-induced cardiopulmonary changes are similar to venom (Bagchi and Deshpande 1998).…”

Section: Pathophysiology and Clinical Aspectsmentioning

confidence: 99%

Scorpion Venom Research Around the World: Indian Red Scorpion

Strong

Mukherjee²,

Shah³

et al. 2014

Toxinology

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The Indian red scorpion is the medically most important scorpion on the Indian subcontinent, and a sting is often lethal without treatment, especially to young children. The correct identification of this species is Hottentotta tamulus; the more commonly known names, Buthus tamulus and Mesobuthus tamulus, and the suggestions of subspecies (Pocock) are incorrect and should be discouraged. Mild cases of H. tamulus envenoming show vasoconstriction and hypertension resulting from a massive release of catecholamines. Severe cases result in hypotension, pulmonary edema and myocardial dysfunction. Animal studies indicate that catecholamine release is as a consequence of prolonged sodium channel activation and potassium channel inhibition. Pulmonary edema results from many subcellular events, including kinin activation and stimulation of central serotonin receptor subtypes. Treatment with a specific antibody (with or without the a-adrenoreceptor blocker, prazosin, dependent on symptoms and clinical severity) is presently the preferred therapy. The few venom constituents that have been characterized in detail include iberiotoxin, a specific blocker of high conductance, calcium-activated potassium channels; tamapin, a specific blocker of low conductance calcium activated potassium channels (K Ca 2.2 subtype); and the short peptide insectotoxins, ButaIT and BtlTx3.

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Insulin reverses haemodynamic changes and pulmonary oedema in children stung by the Indian red scorpionMesobuthus tamulus concanesis, Pocock

Cited by 45 publications

References 8 publications

On the management of scorpion stings

On the management of scorpion stings

Scorpion Venoms

Scorpion Venom Research Around the World: Indian Red Scorpion

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