2015
DOI: 10.1371/journal.pone.0142633
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Insulin Sensitivity in Adipose and Skeletal Muscle Tissue of Dairy Cows in Response to Dietary Energy Level and 2,4-Thiazolidinedione (TZD)

Abstract: The effects of dietary energy level and 2,4-thiazolidinedione (TZD) injection on feed intake, body fatness, blood biomarkers and TZD concentrations, genes related to insulin sensitivity in adipose tissue (AT) and skeletal muscle, and peroxisome proliferator-activated receptor gamma (PPARG) protein in subcutaneous AT (SAT) were evaluated in Holstein cows. Fourteen nonpregnant nonlactating cows were fed a control low-energy (CON, 1.30 Mcal/kg) diet to meet 100% of estimated nutrient requirements for 3 weeks, aft… Show more

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Cited by 20 publications
(38 citation statements)
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References 46 publications
(66 reference statements)
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“…To reconcile the discrepancy between gene expression and serum concentrations, it would be necessary to study the fate of adiponectin after release into circulation, where it is present predominantly in the high-molecular-weight form (Giesy et al, 2012;Mielenz et al, 2013). Our results confirm the results by Hosseini et al (2015), who showed a greater mRNA abundance of adiponectin in subcutaneous adipose tissue in overfed nonlactating, nonpregnant cows, yet serum concentration was reduced in that group compared with the control group. Likewise, Singh et al (2014b) found no correlations (r < 0.275) between serum adiponectin concentrations and gene expression in visceral and subcutaneous adipose tissue depots.…”
supporting
confidence: 84%
“…To reconcile the discrepancy between gene expression and serum concentrations, it would be necessary to study the fate of adiponectin after release into circulation, where it is present predominantly in the high-molecular-weight form (Giesy et al, 2012;Mielenz et al, 2013). Our results confirm the results by Hosseini et al (2015), who showed a greater mRNA abundance of adiponectin in subcutaneous adipose tissue in overfed nonlactating, nonpregnant cows, yet serum concentration was reduced in that group compared with the control group. Likewise, Singh et al (2014b) found no correlations (r < 0.275) between serum adiponectin concentrations and gene expression in visceral and subcutaneous adipose tissue depots.…”
supporting
confidence: 84%
“…We previously reported that in dry and non-pregnant dairy cows fed a control lower-energy (CON) or higher-energy (OVE) diet receiving 4 mg of TZD/kg of BW daily for 2 wk [ 8 ] the concentrations of glucose (4.55 vs. 4.65 mmol/L), insulin (27 vs. 35 μU/mL), and (BHBA) (0.27 vs. 0.37) were increased during the TZD administration (2 to 4 wk after diet initiation). In contrast, the concentration of NEFA (0.18 vs. 0.15 mmol/L) and adiponectin (ADIPOQ; 34.6 vs. 30.3 μg/L) remained unchanged during TZD administration.…”
Section: Introductionmentioning
confidence: 99%
“…More importantly, the ratios of glucose/insulin (0.51 vs. 0.54) and NEFA/insulin (0.22 vs. 0.18) decreased during TZD, suggesting an improvement in insulin sensitivity. The mRNA expression in subcutaneous adipose tissue of PPARG and its targets FASN and SREBF1 , which are the main regulators of adipogenesis and lipogenesis, were upregulated by TZD [ 8 ]. Greater expression of the insulin sensitivity-related genes IRS1 , SLC2A4 , INSR , SCD , INSIG1 , DGAT2 , and ADIPOQ in subcutaneous adipose tissue of OVE cows indicated that greater energy intake did not impair insulin sensitivity.…”
Section: Introductionmentioning
confidence: 99%
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