Insulin Sensitivity in Vitamin B₆-Deficient Rats

Abstract

Increased insulin sensitivity of vitamin B₆-deficient rat adipose tissue may be related in part to altered GH metabolism. The metabolism of glucose-U-¹⁴C in muscle and adipose tissue was determined in vivo as a function of insulin, GH and combined insulin-GH treatments. Vitamin B₆-deficient rats were more sensitive to insulin and acute GH treatments, which exerted an insulin-like effect, than were ad libitum or pair-fed controls. Chronic GH treatment had an insulin-like effect on muscle and potentiated the action of insulin, while it inhibited the action of insulin in adipose tissue. The degree of response to chronic GH treatment was greatest in the vitamin B₆-deficient rats. The data provide evidence that chronic GH treatment modified insulin sensitivity in vitamin B₆-deficient rats.

Vitamin B6 Supplementation Improves Oxidative Stress and Enhances Serum Paraoxonase/Arylesterase Activities in Streptozotocin-Induced Diabetic Rats

“…There are contradictory reports regarding vitamin B6 levels in the type 1 diabetes mellitus. Leklem and Hollenbeck reported that [24] hyperglycemia induced vitamin B6 deficiency while others [25, 51] suggested that vitamin B6 deficiency induced a decrease in circulating insulin levels which resulted in diabetes. Okada et al proposed that diabetic rats should have a higher intake of vitamin B6 since diabetic state could lead to a vitamin B6 deficiency and might require vitamin B6 supplementation [27].…”

Effect of diabetes on vitamin B6 requirement in experimental animals

“…There are contradictory reports regarding vitamin B6 metabolism in diabetes. One report stated that hyperglycaemia induces vitamin B6 deficiency[1] and others reported that vitamin B6 deficiency induces a decrease in circulating insulin levels which results in diabetes[2, 3]. In previous studies, the glucose content in the plasma of vitamin B6‐depleted rats never exceeded that of the controls, but rather tended to decrease in the vitamin B6‐deficient rat[4–6].…”

Vitamin B6 (pyridoxamine) supplementation and complications of diabetes

“…Vitamin B 6 deficiency in animals is known to reduce pancreatic and circulating insulin levels [22]. Vitamin B 6 deficiency has been associated with degenerative changes in h-cells in the islets of Langerhans and abnormal glucose tolerance [23].…”