Vitamin B6 Supplementation Improves Oxidative Stress and Enhances Serum Paraoxonase/Arylesterase Activities in Streptozotocin-Induced Diabetic Rats

Abstract

The purpose of this study was to investigate the effects of vitamin B6 (Vit B6) on oxidant and antioxidant status in streptozotocin-induced diabetic rats. Thirty-two Wistar rats were divided into four groups: control (C), control + Vit B6 group (C + Vit B6), diabetes (D), and diabetes + Vit B6 group (D + Vit B6). Vit B6 (4 mg/kg body weight) was administered in drinking water for 4 weeks after the induction of diabetes. Vitamin B6 reduced serum total cholesterol level in the C + Vit B6 (P < 0.01) and D + Vit B6 (P < 0.05) groups. Plasma and tissue malondialdehyde levels were reduced in the C + Vit B6 and D + Vit B6 groups. Whole blood glutathione peroxidase (GSH-Px) and erythrocyte superoxide dismutase (SOD) activities were higher in the D group (P < 0.05). GSH-Px and SOD activities were increased in C + Vit B6 group while these parameters decreased in the D + Vit B6 group. Paraoxonase and arylesterase activities were decreased in the D group while they were increased in C + Vit B6 and D + Vit B6 groups. The results of present study suggest that vitamin B6 supplementation might be a promising adjunctive agent for improving oxidative stress and metabolic disturbances and for preventing diabetic complications including atherogenesis.

In-vivo, hypoglycemic, hypolipidemic and oxidative stress inhibitory activities of Myrtus communis L. fruits hydroalcoholic extract in normoglycemic and streptozotocin-induced diabetic rats

“…In fact, many previous studies suggested that PON and ARE activities can reduce diabetes mellitus complications [20,47,52]. However, other studies indicated that the inactivation of antioxidant enzymes such as PON1 might be prevented by the addition of antioxidant vitamins or herbal supplements [53][54][55].…”

Impact of Supplementary Amino Acids, Micronutrients, and Overall Diet on Glutathione Homeostasis

“…Conversely, vitamin B 6 supplementation had no effect on hepatic GSH levels in control rats, with or without supplementation [135], nor did it alter GPx levels in homocysteinemic rats [133]. Unexpectedly, vitamin B 6 supplementation increased blood GPx levels of control rats, indicating that the vitamin may directly stimulate the GSH redox system under normal conditions [138].…”

Elevated level of renal xanthine oxidase mRNA transcription after nephropathogenic infectious bronchitis virus infection in growing layers

“…However, to prevent tissue damage caused by oxidative stress, the major antioxidant enzymes such as superoxide dismutases (SOD) and glutathione peroxidase (GSH-PX) played an important role in maintaining the balance between antioxidants and oxidation in vivo [ 17 27 ]. Tas et al [ 31 ] reported that increased activities of SOD and GSH-PX could reduce the oxidative damage induced by reactive oxygen species (ROS) in rats.…”