Insulin sensitivity increase after calcium supplementation and change in intraplatelet calcium and sodium–hydrogen exchange in hypertensive patients with Type 2 diabetes<sup>1</sup>

Pikilidou, Maria; Lasaridis, Anastasios N.; Sarafidis, Pantelis A.; Befani, Christina; Koliakos, George; Tziolas, Ioannis M.; Kazakos, Kyriakos; Yovos, John G.; Nilsson, Peter M.

doi:10.1111/j.1464-5491.2009.02673.x

Cited by 44 publications

(24 citation statements)

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“…42 Accordingly, it is not inconceivable that this transient elevation, which would likely occur following each CAL test drink ingested (relative to control) over the 14-d supplemental period, underlies the increase in insulinemia and HOMA-IR in the basal state. These findings conflict with some previous work whereby calcium supplementation improves 43,44 or does not influence 45 insulin sensitivity. These studies however were performed in individuals at risk of, or diagnosed with, type 2 diabetes.…”

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confidence: 99%

The influence of calcium supplementation on substrate metabolism during exercise in humans: a randomized controlled trial

et al. 2014

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BACKGROUND/OBJECTIVES: High calcium intakes enhance fat loss under restricted energy intake. Mechanisms explaining this may involve reduced dietary fat absorption, enhanced lipid utilization and (or) reductions in appetite. This study aimed to assess the impact of 2 weeks of calcium supplementation on substrate utilization during exercise and appetite sensations at rest. SUBJECTS/METHODS: Thirteen physically active males completed two 14-d supplemental periods, in a double-blind, randomized crossover design separated by a ⩾ 4-week washout period. During supplementation, a test-drink was consumed daily containing 400 and 1400 mg of calcium during control (CON) and high-calcium (CAL) periods, respectively. Cycling-based exercise tests were conducted before and after each supplemental period to determine substrate utilization rates and circulating metabolic markers (non-esterified fatty acid, glycerol, glucose and lactate concentrations) across a range of exercise intensities. Visual analog scales were completed in the fasting, rested state to determine subjective appetite sensations. RESULTS: No significant differences between supplements were observed in lipid or carbohydrate utilization rates, nor in circulating metabolic markers (both P>0.05). Maximum rates of lipid utilization were 0.47 ± 0.05 and 0.44 ± 0.05 g/min for CON and CAL, respectively, prior to supplementation and 0.44 ± 0.05 and 0.42 ± 0.05 g/min, respectively, post-supplementation (main effects of time, supplement and time x supplement interaction effect all P>0.05). Furthermore, no significant differences were detected in any subjective appetite sensations (all P>0.05). CONCLUSIONS: Two weeks of calcium supplementation does not influence substrate utilization during exercise in physically active males.

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The influence of calcium supplementation on substrate metabolism during exercise in humans: a randomized controlled trial

et al. 2014

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“…A randomized controlled, single-blinded trial with 31 patients demonstrated that oral calcium supplementation (1500 mg/day) for 2 months improves insulin sensitivity in patients with type 2 diabetes and hypertension, however, both fasting blood glucose and HbA1c levels were unaffected by the calcium supplementation [42]. Furthermore, it was shown that dietary calcium supplementation (600 mg/day) for 3 months significantly reduced vascular resistance and induced partial regression of left ventricular hypertrophy in hypertensive non-insulin-dependent diabetic Afro-Americans [13].…”

Section: Discussionmentioning

confidence: 99%

Anti-diabetic effect of a preparation of vitamins, minerals and trace elements in diabetic rats: a gender difference

et al. 2014

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BackgroundAlthough multivitamin products are widely used as dietary supplements to maintain health or as special medical food in certain diseases, the effects of these products were not investigated in diabetes mellitus, a major cardiovascular risk factor. Therefore, here we investigated if a preparation of different minerals, vitamins, and trace elements (MVT) for human use affects the severity of experimental diabetes.MethodsTwo days old neonatal Wistar rats from both genders were injected with 100 mg/kg of streptozotocin or its vehicle to induce diabetes. At week 4, rats were fed with an MVT preparation or vehicle for 8 weeks. Well established diagnostic parameters of diabetes, i.e. fasting blood glucose and oral glucose tolerance test were performed at week 4, 8 and 12. Moreover, serum insulin and blood HbA1c were measured at week 12.ResultsAn impaired glucose tolerance has been found in streptozotocin-treated rats in both genders at week 4. In males, fasting blood glucose and HbA1c were significantly increased and glucose tolerance and serum insulin was decreased at week 12 in the vehicle-treated diabetic group as compared to the vehicle-treated non-diabetic group. All of the diagnostic parameters of diabetes were significantly improved by MVT treatment in male rats. In females, streptozotocin treatment resulted in a less severe prediabetic-like phenotype as only glucose tolerance and HbA1c were altered by the end of the study in the vehicle-treated diabetic group as compared to the vehicle-treated non-diabetic group. MVT treatment failed to improve the diagnostic parameters of diabetes in female streptozotocin-treated rats.ConclusionThis is the first demonstration that MVT significantly attenuates the progression of diabetes in male rats with chronic experimental diabetes. Moreover, we have confirmed that females are less sensitive to STZ-induced diabetes and MVT preparation did not show protection against prediabetic state. This may suggest a gender difference in the pathogenesis of diabetes.

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“…It has been shown that elevation in intracellular Ca 2+ may result in insulin resistance by affecting the phosphorylation of GLUT-4 [35] and affecting insulin-mediated glucose transport and insulin secretion, leading to insulin resistance and T2D [36,37]. However, 8 weeks of oral Ca 2+ supplementation at 1500 mg per day improved insulin sensitivity by reducing the concentration of intracellular ionic Ca 2+ in 31 diabetic and hypertensive individuals [38]. Furthermore, a previous study reported that 8 weeks of Ca 2+ intake improves insulin sensitivity in essential hypertensive patients [39].…”

Section: Discussionmentioning

confidence: 99%

Effect of Opuntia humifusa Supplementation and Acute Exercise on Insulin Sensitivity and Associations with PPAR-γ and PGC-1α Protein Expression in Skeletal Muscle of Rats

Kang

Lee

Kwon

et al. 2013

IJMS

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This study examined whether Opuntia humifusa (O. humifusa), which is a member of the Cactaceae family, supplementation and acute swimming exercise affect insulin sensitivity and associations with PPAR-γ and PGC-1α protein expression in rats. Thirty-two rats were randomly divided into four groups (HS: high fat diet sedentary group, n = 8; HE: high fat diet acute exercise group, n = 8; OS: 5% O. humifusa supplemented high fat diet sedentary group, n = 8; OE: 5% O. humifusa supplemented high fat diet acute exercise group, n = 8). Rats in the HE and OE swam for 120 min. before being sacrificed. Our results indicated that serum glucose level, fasting insulin level and homeostasis model assessment of insulin resistance (HOMA-IR) in OS were significantly lower compared to those of the HS (p < 0.01, p < 0.05, p < 0.05). In addition, PPAR-γ protein expression in the OS and OE was significantly higher than that of the HS and HE, respectively (p < 0.05, p < 0.01). PGC-1α and GLUT-4 protein expressions in the OS were significantly higher compared to those of the HS (p < 0.05, p < 0.05). From these results, O. humifusa supplementation might play an important role for improving insulin sensitivity through elevation of PPAR-γ, PGC-1α, and GLUT-4 protein expression in rat skeletal muscle.

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Insulin sensitivity increase after calcium supplementation and change in intraplatelet calcium and sodium–hydrogen exchange in hypertensive patients with Type 2 diabetes¹

Cited by 44 publications

References 47 publications

The influence of calcium supplementation on substrate metabolism during exercise in humans: a randomized controlled trial

The influence of calcium supplementation on substrate metabolism during exercise in humans: a randomized controlled trial

Anti-diabetic effect of a preparation of vitamins, minerals and trace elements in diabetic rats: a gender difference

Effect of Opuntia humifusa Supplementation and Acute Exercise on Insulin Sensitivity and Associations with PPAR-γ and PGC-1α Protein Expression in Skeletal Muscle of Rats

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Insulin sensitivity increase after calcium supplementation and change in intraplatelet calcium and sodium–hydrogen exchange in hypertensive patients with Type 2 diabetes1

Cited by 44 publications

References 47 publications

The influence of calcium supplementation on substrate metabolism during exercise in humans: a randomized controlled trial

The influence of calcium supplementation on substrate metabolism during exercise in humans: a randomized controlled trial

Anti-diabetic effect of a preparation of vitamins, minerals and trace elements in diabetic rats: a gender difference

Effect of Opuntia humifusa Supplementation and Acute Exercise on Insulin Sensitivity and Associations with PPAR-γ and PGC-1α Protein Expression in Skeletal Muscle of Rats

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Insulin sensitivity increase after calcium supplementation and change in intraplatelet calcium and sodium–hydrogen exchange in hypertensive patients with Type 2 diabetes¹