Insulin therapy for adult patients with type 2 diabetes mellitus: a position statement of the Korean Diabetes Association, 2017

Lee, Byung‐Wan; Kim, Jin Hwa; Ko, Seung‐Hyun; Hur, Kyu Yeon; Kim, Nan‐Hee; Rhee, Sang Youl; Kim, Hyun Jin; Moon, Min Kyong; Park, Seok-O; Choi, Kyung Mook

doi:10.3904/kjim.2017.314

Cited by 6 publications

(5 citation statements)

References 39 publications

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“…Prescription errors were shown to be responsible for 70% of drug errors. The total number of prescriptions analyzed in the current study, 35 were noticeable, with medication errors 24 . This might be due to a few reasons, such as problems in handwriting, abbreviated forms, and insufficient medication orders 25 .…”

Section: Fig 4: Distribution Of Drug-drug Interactions In Patientsmentioning

confidence: 68%

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2023

IJPSR

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Type 2 diabetes mellitus is a lifestyle disorder with a deficiency in insulin secretion or loss of insulin sensitivity in the body. As the prevalence is becoming more global, a focus was made on the innovation of analyzing the latest treatments. A prospective observational study on drug utilization patterns for diabetes was conducted on 119 diabetic patients admitted in a tertiary care hospital. A specified informed consent form was collected from the patients prior to the study. All the relevant data was collected and analyzed. In the present study, the prevalence of Type 2 diabetes mellitus was highest in patients aged 60-69 years, affecting 43.7% males and 56.3% females. The commonest co-morbid condition was hypertension (63%) followed by coronary artery disease (10.9%) and chronic kidney disease (9.2%). When it comes to the treatment, insulin was prescribed for about 90 (75.6%) diabetic patients, followed by oral hypoglycaemic agents (OHAs) (n=29; 24.4%). Amongst the drugs, it was also noted that 61 patients (51.2%) were administered metformin alone while the remaining patients were given insulin and other OHAs. The above results concluded that metformin was the only drug prescribed persistently and was the drug of choice for type 2 diabetes mellitus. The prescribing patterns in the present study give way to clinician/physician to go for better drugs in co-morbid conditions, considering the drug interactions as well.

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Section: Fig 4: Distribution Of Drug-drug Interactions In Patientsmentioning

confidence: 68%

“…A computerized prescription order input system, manual medication review, and pharmacist participation in physician rounds can all help to improve drug safety 24 . As a result, the patient's drug needs must be adequately analyzed to avoid unfavourable side effects.…”

Section: Fig 4: Distribution Of Drug-drug Interactions In Patientsmentioning

confidence: 99%

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2023

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“…In addition, the use of metformin plus GLP-1 RA is increasing. This trend is because sulfonylurea is associated with issues of hypoglycemia or weight gain, while SGLT2 inhibitor and GLP-1 RA have acceptable profiles with significant cardiovascular and renal benefit when used alone and with a weight loss effect in addition to insulin [ 2 ]. DPP-4 inhibitor use is rapidly and widely growing because it seems to be beneficial regarding glycemic control without significant adverse effects [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…Among patients with DM aged 30 years or older, 7.5% patients are estimated to use insulin [ 1 ]. Insulin treatment is necessary for all people with type 1 diabetes mellitus (T1DM) and a subgroup of people with type 2 diabetes mellitus (T2DM) who are no longer able to reach an appropriate glycemic target with oral antidiabetic medication alone or those who have hyperglycemic symptoms or catabolic features [ 2 ]. Patients with T1DM typically require initiation with multiple daily injections (basal [long acting] insulin and bolus [short acting] insulin) or continuous subcutaneous insulin infusion.…”

Section: Introductionmentioning

confidence: 99%

Insulin Fact Sheet in Type 1 and 2 Diabetes Mellitus and Trends of Antidiabetic Medication Use in Insulin Users with Type 2 Diabetes Mellitus: 2002 to 2019

Park

Kim

et al. 2023

Diabetes Metab J

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Background: This study investigated the trends of insulin use among Korean patients with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). Changes in prescription of antidiabetic medications in T2DM patients taking insulin therapy were evaluated. Methods: We analyzed data from the National Health Insurance Service database in Korea to evaluate the prevalence of insulin users and trends of insulin use in T1DM and T2DM patients from January 2002 to December 2019. We also investigated numbers and types of antidiabetic medications in insulin users with T2DM. Results:The overall total number of insulin users increased from 2002 to 2019, reaching 348,254 for T2DM and 20,287 for T1DM in 2019 compared with 109,974 for T2DM and 34,972 for T1DM in 2002. The proportion of patients using basal analogs and short acting analogs have increased and those using human insulin, premixed insulin, or biphasic human insulin have decreased (rapid acting analogs: 71. 85% and 24.12% in T1DM and T2DM, respectively, in 2019; basal analogs: 76.75% and 75.09% in T1DM and T2DM, respectively, in 2019). The use of other antidiabetic medication in addition to insulin increased for T2DM, especially in dual therapy, reaching up to 52.35% in 2019 compared with 16.72% in 2002. Conclusion:The proportion of the patients using basal or rapid acting analogs increased among all insulin users in both T1DM and T2DM patients. Among patients with T2DM, the proportion of patients using antidiabetic medications in addition to insulin was significantly increased compared to those who used insulin alone.

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“…Hypoglycemia was defined as blood glucose level <70 mg/dL based on the value checked after admission [ 10 ]. After admission, insulin dose was increased or decreased appropriately according to the guidelines [ 11 ].…”

Section: Methodsmentioning

confidence: 99%

Differences in Clinical Outcomes between Patients with and without Hypoglycemia during Hospitalization: A Retrospective Study Using Real-World Evidence

Lee

Kim

et al. 2020

Diabetes Metab J

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Background Some patients admitted to hospitals for glycemic control experience hypoglycemia despite regular meals and despite adhering to standard blood glucose control protocols. Different factors can have a negative impact on blood glucose control and prognosis after discharge. This study investigated risk factors for hypoglycemia and its effects on glycemic control during the hospitalization of patients in the general ward. Methods This retrospective study included patients who were admitted between 2009 and 2018. Patients were provided regular meals at fixed times according to ideal body weights during hospitalization. We categorized the patients into two groups: those with and those without hypoglycemia during hospitalization. Results Of the 3,031 patients, 379 experienced at least one episode of hypoglycemia during hospitalization (HYPO group). Hypoglycemia occurred more frequently particularly in cases of premixed insulin therapy. Compared with the control group, the HYPO group was older (61.0±16.8 years vs. 59.1±16.5 years, P =0.035), with more females (60.4% vs. 49.6%, P <0.001), lower body mass index (BMI) (23.5±4.2 kg/m 2 vs. 25.1±4.4 kg/m 2 , P <0.001), and higher prevalence of type 1 diabetes mellitus (6.1% vs. 2.6%, P <0.001), They had longer hospital stay (11.1±13.5 days vs. 7.6±4.6 days, P <0.001). After discharge the HYPO group had lower glycosylated hemoglobin reduction rate (−2.0%±0.2% vs. −2.5%±0.1%, P =0.003) and tended to have more frequent cases of cardiovascular disease. Conclusion Hypoglycemia occurred more frequently in older female patients with lower BMI and was associated with longer hospital stay and poorer glycemic control after discharge. Therefore, clinicians must carefully ensure that patients do not experience hypoglycemia during hospitalization.

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Insulin therapy for adult patients with type 2 diabetes mellitus: a position statement of the Korean Diabetes Association, 2017

Cited by 6 publications

References 39 publications

Untitled

Untitled

Insulin Fact Sheet in Type 1 and 2 Diabetes Mellitus and Trends of Antidiabetic Medication Use in Insulin Users with Type 2 Diabetes Mellitus: 2002 to 2019

Differences in Clinical Outcomes between Patients with and without Hypoglycemia during Hospitalization: A Retrospective Study Using Real-World Evidence

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