Insulinresistenz und metabolisches Syndrom

Abstract

The metabolic syndrome represents a complex combination of the symptoms obesity, insulin resistance, dyslipoproteinemia, hypertension, and type 2 diabetes. These components have a heterogeneous genetic basis and appear to be closely linked. Obesity is determined by a polygenic constellation and produces insulin resistance, hypertension and dyslipidemia. In addition, defects in the signal transduction of insulin appear to aggravate the insulin resistance independent of obesity. Type 2 diabetes is produced by a third genetic predisposition and is precipitated by the failure of pancreatic beta-cell to compensate insulin resistance. Because prevalence and course of the diabetes markedly depend on the extent of obesity and insulin resistance, these symptoms of the metabolic syndrome represent crucial targets for preventive and therapeutic strategies.

The effects of orlistat on body weight and glycaemic control in overweight patients with type 2 diabetes: a randomized, placebo‐controlled trial

“…The accumulation of visceral abdominal adipose tissue, for which waist circumference is an effective surrogate measure, is strongly associated with type 2 diabetes [32]. Abdominal adiposity is also an important component of the cluster of metabolic abnormalities that comprise the insulin resistance syndrome [33,34]. Insulin resistance is obviously of key importance for the progression of diabetes.…”

Regulation of the insulin antagonistic protein tyrosine phosphatase 1B by dietary Se studied in growing rats

“…In industrial countries, the number of patients suffering from obesity, insulin-resistant diabetes and the metabolic syndrome is permanently increasing [1,2]. Concomitantly in the fortification of foodstuffs derived from plants and animals with vitamins, minerals and trace elements including Se by fertilization and animal nutrition is widely practised [3][4][5][6].…”

Serum Leptin in the Development of Insulin Resistance and Other Disorders in the Metabolic Syndrome

“…Single factors of the metabolic syndrome hang together and influence each other. Therefore the effect does not add up, but instead multiplies and increases the risk of cardiovascular morbidity and mortality 13,18,24,25 . Traditionally, adipose tissue was considered as a passive reservoir of energy in the form of triacylglycerol stores and as a place for the conversion of androgens to estrogens.…”