Intact enhancement of declarative memory for emotional material in amnesia.

Hamann, Stephan; Cahill, Larry; McGaugh, James L.; Squire, Larry R.

doi:10.1101/lm.4.3.301

Cited by 87 publications

(64 citation statements)

References 30 publications

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“…For instance, several studies indicate that the amygdala has anatomical and neurochemical properties making it particularly suitable to modulate higher cognitive functions (Emery and Amaral, 2000;Davis and Whalen, 2001;Ghashghaei and Barbas, 2002). In addition, numerous studies have found evidence that the amygdala modulates cognition in the case of the emotional enhancement of long-term memory (Hamann et al, 1997(Hamann et al, , 1999Philippot and Schaefer, 2001;Smith et al, 2005Smith et al, , 2006LaBar and Cabeza, 2006).…”

Section: Discussionmentioning

confidence: 99%

Individual Differences in Amygdala Activity Predict Response Speed during Working Memory

Schaefer¹,

Braver²,

Reynolds³

et al. 2006

J. Neurosci.

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The human amygdala has classically been viewed as a brain structure primarily related to emotions and dissociated from higher cognition. We report here findings suggesting that the human amygdala also has a role in supporting working memory (WM), a canonical higher cognitive function. In a first functional magnetic resonance imaging (fMRI) study (n ϭ 53), individual differences in amygdala activity predicted behavioral performance in a 3-back WM task. Specifically, higher event-related amygdala amplitude predicted faster response time (RT; r ϭ Ϫ0.64), with no loss of accuracy. This relationship was not contingent on mood state, task content, or personality variables. In a second fMRI study (n ϭ 21), we replicated the key finding (r ϭ Ϫ0.47) and further showed that the correlation between the amygdala and faster RT was specific to a high working memory load condition (3-back) compared with a low working memory load condition (1-back). These results support models of amygdala function that can account for its involvement not only in emotion but also higher cognition.

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Section: Discussionmentioning

confidence: 99%

Individual Differences in Amygdala Activity Predict Response Speed during Working Memory

Schaefer¹,

Braver²,

Reynolds³

et al. 2006

J. Neurosci.

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“…Other studies suggest that amygdala damage eliminates the facilitatory effect of arousal, but does not alter the effect of emotional valence (Phelps et al, 1998). In fact, there is a double dissociation between the effects of hippocampal and amygdaloid damage: medial-temporal amnesics still show enhanced recall for emotional stimuli (Hamann et al, 1997), but amygdala patients do not differ from healthy controls on recall of nonemotional stimuli (Adolphs et al, 1997). Finally, although the amygdala plays a role in the encoding of emotional stimuli, little is known of its role during retrieval; one study reports left amygdala activation during the retrieval of emotional memories (Dolan et al, 2000), while another reports right amygdala activity during autobiographical memory retrieval in general (Fink et al, 1996).…”

Section: Neuropsychological Datamentioning

confidence: 99%

The Neuropsychology of Autobiographical Memory

Greenberg

Rubin

2003

Cortex

254

151

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This special issue of Cortex focuses on the relative contribution of different neural networks to memory and the interaction of 'core' memory processes with other cognitive processes. In this article, we examine both. Specifically, we identify cognitive processes other than encoding and retrieval that are thought to be involved in memory; we then examine the consequences of damage to brain regions that support these processes. This approach forces a consideration of the roles of brain regions outside of the frontal, medialtemporal, and diencephalic regions that form a central part of neurobiological theories of memory. Certain kinds of damage to visual cortex or lateral temporal cortex produced impairments of visual imagery or semantic memory; these patterns of impairment are associated with a unique pattern of amnesia that was distinctly different from the pattern associated with medial-temporal trauma. On the other hand, damage to language regions, auditory cortex, or parietal cortex produced impairments of language, auditory imagery, or spatial imagery; however, these impairments were not associated with amnesia. Therefore, a full model of autobiographical memory must consider cognitive processes that are not generally considered 'core processes,' as well as the brain regions upon which these processes depend.

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“…GABA agonists infused directly into the amygdala immediately after training impaired retention (Castellano et al 1989;Willensky et al 2000). Amygdala is reported to play a crucial role, preferentially in avoidance learning than spatial learning (Takashina et al 1995) and is also involved with the formation of enhanced declarative memory for emotionally arousing events (Adolphs et al 1997;Cahill and McGaugh 1998;Hamann et al 1997). Declarative memory also depends on signals from the hippocampus and other parts of the medial temporal lobe of the brain for its retention.…”

Section: Memory Retention and Cognitionmentioning

confidence: 99%

Psychomotor functions at various weeks of chronic renal failure in rats

Chandanathil¹,

Upadhya

Bhat³

2014

Cogn Neurodyn

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In chronic renal failure there is a gradual retention of substances in the tissues and body fluids, called as uremic retention toxins, which can bring about a number of biochemical activities in the body. Chronic renal insufficiency also leads to progressive behavioural conflict. Uremic toxins can affect both the central and the peripheral nervous system. Uremic encephalopathy is also associated with problems in cognition and memory. To study the psychomotor functional disorders in rats with progressive chronic renal failure surgical nephrectomy was done by resection method. The animals were grouped into two control groups, Sham control (SC) and normal control (NC) and two uremic groups, moderate uremia (G M ) and severe uremia (G S ). Psychomotor analysis was done by passive avoidance and open field in these animals at 4, 8, 12, and 16 weeks. After the incubation period, the nephrectomised groups (G M and G S ) showed significant changes in exploratory, locomotor and emotional behaviour when compared to the controls (NC and SC). Psychomotor changes involve poor cognition, reduced memory, reduced locomotor activity and decreased exploratory drive and emotional disturbance like increased fear during the initial stages. During the later stages a restless behaviour was noticed, associated with diminished fear.

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Intact enhancement of declarative memory for emotional material in amnesia.

Cited by 87 publications

References 30 publications

Individual Differences in Amygdala Activity Predict Response Speed during Working Memory

Individual Differences in Amygdala Activity Predict Response Speed during Working Memory

The Neuropsychology of Autobiographical Memory

Psychomotor functions at various weeks of chronic renal failure in rats

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