Intake Of Dioxins and Related Compounds from Food in the U.S. Population

Schecter, Arnold; Cramer, P.H.; Boggess, Kathy; Stanley, J.S.; Päpke, Olaf; Olson, James R.; Silver, Andrew; Schmitz, Michael

doi:10.1080/152873901750128326

Cited by 207 publications

(122 citation statements)

References 29 publications

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“…The daily dioxin intake (DDI) was estimated as per previous publications by assuming that the infant (0-24 weeks) consumes 800 ml of milk per day (Schecter et al 2001, Tai et al 2011) and taking the weight of the infant at the time into account. The intake value was calculated using the following equation: DDI = 800 × (% fat content of milk/100) × (PCDD/PCDF TEQ in breast milk in pg/g lipid)/(kg of infant weight).…”

Section: Estimation Of the Daily Dioxin Intake Of Infants From Breastmentioning

confidence: 99%

Low birth weight of Vietnamese infants is related to their mother’s dioxin and glucocorticoid levels

Tung

Kido

Honma

et al. 2016

Environ Sci Pollut Res

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We aimed to determine the relationship between dioxin congeners in maternal breast milk and maternal glucocorticoid levels with newborn birth weight after nearly 45 years of use of herbicides in the Vietnam War. The study subjects comprised 58 mother-infant pairs in a region with high dioxin levels in the soil (hotspot) and 62 pairs from a control region. Dioxin levels in maternal breast milk were measured by HRGC-HRMS. Salivary glucocorticoid levels were determined by LC-MS/MS. Dioxin congener levels in mothers from the hotspot were found to be 2-5-fold higher than those in mothers from the control region. Birth weight was inversely correlated with 2,3,7,8-TeCDD and 2,3,4,7,8-PeCDF congener levels. The rate of newborns whose birth weight was less than 2500 g was 3-fold higher in the hotspot (12%) than in the control region (4%). Salivary glucocorticoid levels in mothers with low birth weight infants were significantly higher than those in the normal birth weight group. Low birth weight of Vietnamese newborns in a hotspot for dioxin levels is related to some dioxin congener levels and high glucocorticoid levels in mothers. This finding in mother-infant pairs suggests that excess maternal glucocorticoid levels are related to dioxin burden and they result in low birth weight.

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Section: Estimation Of the Daily Dioxin Intake Of Infants From Breastmentioning

confidence: 99%

Low birth weight of Vietnamese infants is related to their mother’s dioxin and glucocorticoid levels

Tung

Kido

Honma

et al. 2016

Environ Sci Pollut Res

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“…Because on their fat-seeking nature, they can bioaccumulate throughout the food chain, finally reaching humans. The major route of human exposure to dioxins and furans is through the consumption of food (490%) such as milk, dairy products, fish, meat, and eggs (Schecter et al, 2001). Current background exposure to dioxins results in a daily uptake of approximately 1-3 pg TEQ (toxicity equivalents)/kg body wt.…”

Section: Introductionmentioning

confidence: 99%

Dioxin-like components in human breast milk collected from Hong Kong and Guangzhou

Lai¹,

Li²,

Xu³

et al. 2004

Environmental Research

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“…In the last decade, incidences of contamination of animal products (chickens, eggs, some pigs and cattle, and dairy products) with BCB-and dibenzofuran (Schecter et al, 2001) were reported in Europe and USA. The mechanism of dioxin toxicity is not clear.…”

Section: Application Of Proteomics In Animal and Feed Sciencesmentioning

confidence: 99%

Application of nutrigenomics tools in animal feeding and nutritional research

Zduńczyk¹,

Pareek²

2009

J. Anim. Feed Sci.

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The development of nutrigenomic studies has brought about a number of new research tools (transcriptomics, proteomics and metabolomics), which are important in animal nutrition and food research. This review presents an overview on the application of nutrigenomics tools in this scientifi c area. The use of microarray technologies -the main tools of transcriptomics, has allowed new information concerning the physiological effect of different dietary proteins, of omega-3 polyunsaturated fatty acids and dietary conditioning of colon cancer, to be obtained. The use of proteomics tools (mainly two-dimensional electrophoresis) revealed new information concerning the protein composition of egg and poultry meat proteins, the effect of dietary methionine on breast-meat accretion, the toxicity of dioxin and the safe use of transgenic crops in animal nutrition. Metabolomic analysis allowed the detection of changes in the biochemical profi les of plasma and urine from pigs fed different diets and the determination of metabolite profi les in the liver of rats used as an animal model to characterize the toxicity of triazol fungicides. In livestock species, the microarray technology was discussed and reviewed as potential nutrigenomics tools, in context to its economic benefi ts and improvement of the food quality and safety in dairy and meat industries. However, the newly emerged nutrigenomics tools like -gene expression-based biomarker development still poses a major challenge. Finally, latest developments in the standardization of metobolomics data in relation to functional genomics, nutrigenomics and toxicology studies are discussed.

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Intake Of Dioxins and Related Compounds from Food in the U.S. Population

Abstract: The first U.S. nationwide food sampling with measurement of dioxins, dibenzofurans, and coplanar, mono-ortho and di-ortho

Cited by 207 publications

References 29 publications

Low birth weight of Vietnamese infants is related to their mother’s dioxin and glucocorticoid levels

Low birth weight of Vietnamese infants is related to their mother’s dioxin and glucocorticoid levels

Dioxin-like components in human breast milk collected from Hong Kong and Guangzhou

Application of nutrigenomics tools in animal feeding and nutritional research

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