Intake of selected foods and beverages and serum uric acid levels in adults: ELSA-Brasil (2008–2010)

Silva, Michelle Timóteo da; Diniz, Maria de Fátima Haueisen Sander; Coelho, Carolina Gomes; Vidigal, Pedro Guatimosim; Telles, Rosa Weiss; Barreto, Sandhi Maria

doi:10.1017/s1368980019002490

Cited by 21 publications

(17 citation statements)

References 35 publications

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“…Acute gout is a painful crippling state, and left untreated, chronic gout can lead to chronic joint pain, joint erosion, injury, and form gout nodule, which can rupture, infect or cause other complications, such as hypertension [6,7], chronic kidney disease [8,9], obesity, diabetes [10], myocardial congestion, stroke [11,12]. Besides, hyperuricemia is associated with chronic kidney disease (CKD), cardiovascular disease, hypertension, diabetes, metabolic syndrome, and obesity [13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

The Association between Purine-Rich Food Intake and Hyperuricemia: A Cross-Sectional Study in Chinese Adult Residents

Aihemaitijiang

Zhang

et al. 2020

Nutrients

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Objective: To explore the correlation between purine-rich food intake and hyperuricemia in Chinese adult residents. Method: A cross-sectional study was conducted on the purine-rich food intake of Chinese adult residents based on the China Health and Nutrition Survey (CHNS) in 2009. The subjects were divided into hyperuricemia group and nonhyperuricemia group according to serum uric acid level, and the differences of the sociodemographic information (age, gender, and region), health status (weight status, blood pressure, blood sugar status), living habits (alcohol consumption, smoking status) and food intake (purine-rich food, other food) were compared between the two groups. Logistic regressions investigated the associations between the daily intake of purine-rich food (animal-derived food and legumes) and hyperuricemia. Results: Eventually, 6813 subjects were included in our study, 1111 of them had hyperuricemia. The intake of seafood, legumes, red meat, and poultry all increased the risk of hyperuricemia (p < 0.05), while the intake of purine-rich fungi and purine-rich vegetables did not affect the occurrence of hyperuricemia. Animal-derived food was the main source of purine-rich food consumed by Chinese adult residents (140.67g/day), which had a great impact on hyperuricemia. Finally, after adjusting for gender, age, region, body mass index (BMI), alcohol consumption, hypertension, and refined grains intake, the risk of hyperuricemia increased by 2.40% and 1.10% for each increase of 10 g in animal-derived food intake (OR = 1.024, 95% CI: 1.018–1.030) and legumes intake (OR = 1.011, 95% CI: 1.003–1.019), respectively. Conclusion: The intake of animal-derived food and legumes were positively correlated with the occurrence of hyperuricemia. Controlling the intake of animal-derived food and legumes would be more beneficial to controlling the risk of hyperuricemia.

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Section: Introductionmentioning

confidence: 99%

The Association between Purine-Rich Food Intake and Hyperuricemia: A Cross-Sectional Study in Chinese Adult Residents

Aihemaitijiang

Zhang

et al. 2020

Nutrients

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“…For instants, revealed by the Third National Health Nutrition Examination Survey (NHANES III), alcohol intake (especially beer and liquor) was positively associated with SUA level ( 35 ). A study in Brazilian also supported that alcoholic beverage was associated with increased SUA ( 36 ). The mechanism of this association may be explained by that ethanol intake could increase SUA via either increased urate production resulting from enhanced turnover of adenine dinucleotide phosphate, or decreased renal excretion of uric acid which is the secondary to lactate levels, whereby lactate can competitively inhibit urate secretion by the proximal tubule ( 37 – 39 ).…”

Section: Discussionmentioning

confidence: 85%

“…For instants, revealed by the Third National Health Nutrition Examination Survey (NHANES III), alcohol intake (especially beer and liquor) was positively associated with SUA level (35). A study in Brazilian also supported that alcoholic beverage was associated with increased SUA (36). The mechanism of this association may be explained by that ethanol intake could increase SUA via either increased urate production FIGURE 3 | Alcohol consumption associations with SUA among men using QRs.…”

Section: Discussionmentioning

confidence: 97%

The Effect of Body Adiposity and Alcohol Consumption on Serum Uric Acid: A Quantile Regression Analysis Based on the China National Health Survey

Pan²,

Ren³

et al. 2022

Front. Nutr.

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Adiposity and alcohol consumption are reported to be associated with a higher level of serum uric acid (SUA), but whether their effect differs on SUA percentile distribution is still unclear. In this study, we aimed to investigate how alcohol intake and body fat percentage (%BF) integrated with body mass index (BMI) influence the distribution of SUA in Chinese adults. Data from the China National Health Survey (CNHS) which included adults from 10 provinces of China were used (n = 31,746, aged 20–80 years, 40% male). %BF and BMI were integrated into eight expanded body composition groups to understand how excess body adiposity affects the distribution of SUA in the populational level. Self-report alcohol intake information was collected by face-to-face questionnaire interview. Quantile regression (QR) was used to analyze the data. We found that adiposity and alcohol consumption were associated with SUA, especially at the upper percentile in both sexes. In obese men, the QR coefficients at the 75th and 95th percentiles were 74.0 (63.1–84.9) and 80.9 (52.5–109.3) μmol/L, respectively. The highest quartile of %BF in men had a 92.6 (79.3–105.9) μmol/L higher SUA levels at its 95th percentile than the 5th quartile (p < 0.001). Compared with normal or underweight with the lowest %BF group (NWBF1), the obesity-highest %BF group (OBBF4) had the strongest positive effect on SUA, especially at the higher percentile of SUA. In BMI-defined normal or underweight participants, a higher quartile of %BF had greater effect size in all SUA percentiles. In men, current alcohol drinking had the strongest effect at the 95th percentile of SUA (QR coefficient: 31.8, with 95% CI: 22.6–41.0) comparing with 14.5, 95% CI of 8.4 to 20.6 in the 5th SUA percentile. High risk of alcohol consumption had a greater effect on SUA, especially in the higher SUA percentile. The observation of stronger association at the higher percentile of SUA suggests that decreasing body adiposity and alcohol intake at the populational level may shift the upper tails of the SUA distributions to lower values, thereby reducing the incidence of hyperuricemia.

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“…We adjusted for important confounding factors, such as skin color, glomerular filtration rate, and use of interfering drugs. Another significant adjustment was dietary intake of dairy products and animal protein recognized as factors that can be protective or increase the risk of hyperuricemia and diabetes, respectively 12,32 . We also tested whether SUA and skin color were effect modifiers on glycemic status associations by multiplicative interaction terms between uric acid/skin color, with no change in OR.…”

Section: Discussionmentioning

confidence: 99%

The positive association between serum uric acid, impaired fasting glucose, impaired glucose tolerance, and diabetes mellitus in the ELSA-Brasil study

Galvão

Vidigal

et al. 2021

Cad. Saúde Pública

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There is a conflict in the literature regarding the association between serum uric acid (SUA) levels and glycemic status. Therefore, we evaluated the association between SUA level and glycemic status - impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes mellitus - and insulin resistance, in a large Brazilian study. This is a cross-sectional, observational study with 13,207 participants aged 35-74 years, at baseline (2008-2010) of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). A multinomial regression analysis was performed to test the association between SUA and glycemic status (IFG, IGT, and newly diagnosed type 2 diabetes at the cohort baseline) after adjustments by age, sex, skin color, body mass index, physical activity, smoking, alcohol consumption, comorbidities, and medicines use. Logistic regression model was used to evaluate the association between SUA and insulin resistance by HOMA-IR. Stratified analyses by sex were performed. The mean age (standard deviation) was 51.4 (8.9) years, 55.2% of participants were women. There were 1,439 newly diagnosed diabetes. After all adjustments, higher SUA was associated with IFG, IGT, and diabetes, with odds ratio (OR) = 1.15 (95%CI: 1.06; 1.25), 1.23 (95%CI: 1.14; 1.33), and 1.37 (95%CI: 1.24; 1.51), respectively. There was association between SUA levels and insulin resistance with OR = 1.24 (95%CI: 1.13; 1.36). In analysis stratified by sex, higher SUA persisted independently associated with impaired glycemic status. Our results suggest that a higher SUA levels were significantly associated with glycemic status in a large Latin American population, mainly among women.

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Intake of selected foods and beverages and serum uric acid levels in adults: ELSA-Brasil (2008–2010)

Cited by 21 publications

References 35 publications

The Association between Purine-Rich Food Intake and Hyperuricemia: A Cross-Sectional Study in Chinese Adult Residents

The Association between Purine-Rich Food Intake and Hyperuricemia: A Cross-Sectional Study in Chinese Adult Residents

The Effect of Body Adiposity and Alcohol Consumption on Serum Uric Acid: A Quantile Regression Analysis Based on the China National Health Survey

The positive association between serum uric acid, impaired fasting glucose, impaired glucose tolerance, and diabetes mellitus in the ELSA-Brasil study

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