Intake of unsaturated fatty acids and HDL cholesterol levels are associated with manifestations of atopy in adults

Schäfer, Torsten; Ruhdorfer, S.; Weigl, L.; Wessner, D.; Heinrich, Joachim; Döring, Angela; Wichmann, H‐Erich; Ring, Johannes

doi:10.1046/j.1365-2222.2003.01780.x

Cited by 64 publications

(85 citation statements)

References 23 publications

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“…Although prior studies have also assessed the relationship between serum HDL-C and asthma, the results have been heterogeneous with serum HDL-C levels either being increased, decreased, or unchanged in subjects with asthma (20,(43)(44)(45)(46)(47)(48)(49)(50). Similar to our findings, prior studies have also not found a change in serum LDL-C in subjects with asthma, whereas TC was either decreased or unchanged and TG levels were either increased or unchanged.…”

Section: Discussionsupporting

confidence: 80%

Serum Apolipoprotein A-I and Large High-Density Lipoprotein Particles Are Positively Correlated with FEV₁ in Atopic Asthma

Barochia¹,

Kaler²,

Cuento³

et al. 2015

Am J Respir Crit Care Med

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Rationale: Although lipids, apolipoproteins, and lipoprotein particles are important modulators of inflammation, varying relationships exist between these parameters and asthma.Objectives: To determine whether serum lipids and apolipoproteins correlate with the severity of airflow obstruction in subjects with atopy and asthma.Methods: Serum samples were obtained from 154 atopic and nonatopic subjects without asthma, and 159 subjects with atopy and asthma. Serum lipid and lipoprotein levels were quantified using standard diagnostic assays and nuclear magnetic resonance (NMR) spectroscopy. Airflow obstruction was assessed by FEV 1 % predicted.Measurements and Main Results: Serum lipid levels correlated with FEV 1 only in the subjects with atopy and asthma. Serum levels of high-density lipoprotein (HDL) cholesterol and apolipoprotein A-I (apoA-I) were positively correlated with FEV 1 in subjects with atopy and asthma, whereas a negative correlation existed between FEV 1 and serum levels of triglycerides, low-density lipoprotein (LDL) cholesterol, apolipoprotein B (apoB), and the apoB/apoA-I ratio. NMR spectroscopy identified a positive correlation between FEV 1 and HDL NMR particle size, as well as the concentrations of large HDL NMR particles and total IDL NMR (intermediate-density lipoprotein) particles in subjects with atopy and asthma. In contrast, LDL NMR particle size and concentrations of LDL NMR and VLDL NMR (very-low-density lipoprotein) particles were negatively correlated with FEV 1 in subjects with atopy and asthma.Conclusions: In subjects with atopy and asthma, serum levels of apoA-I and large HDL NMR particles are positively correlated with FEV 1 , whereas serum triglycerides, LDL cholesterol, and apoB are associated with more severe airflow obstruction. These results may facilitate future studies to assess whether apoA-I and large HDL NMR particles can reduce airflow obstruction and disease severity in asthma.

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Section: Discussionsupporting

confidence: 80%

Serum Apolipoprotein A-I and Large High-Density Lipoprotein Particles Are Positively Correlated with FEV₁ in Atopic Asthma

Barochia¹,

Kaler²,

Cuento³

et al. 2015

Am J Respir Crit Care Med

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“…Contradictory effects of single fatty acids may have annihilated the effects of the fatty acid families. Furthermore, the allergic component in the present asthma cases might have been secondary (Schafer et al, 2003). Heinrich et al (2001) observed an inverse association between fruit intake and allergic sensitization while no association with vegetable consumption was found.…”

Section: Discussionmentioning

confidence: 60%

Dietary intake of fatty acids, antioxidants and selected food groups and asthma in adults

Nagel

Linseisen

2004

Eur J Clin Nutr

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Objective: Within a prospective study, we explored the associations between dietary intake of fatty acids, antioxidants and relevant food sources of these nutrients on the clinical manifestation of asthma in adulthood. Method: A total of 105 newly physician-diagnosed cases of asthma from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heidelberg cohort were identified during follow-up and matched with 420 controls. Baseline dietary intake was obtained by means of validated food frequency questionnaires. The association of dietary intake variables and asthma risk was explored by unconditional logistic regression models. Results: A high intake of oleic acid (C18:1 n-9) was positively associated with asthma (P-value for trend 0.035), while no significant associations were found for the other dietary fatty acids. Most prominently, a high margarine intake increased the risk of onset of asthma in adulthood (adjusted odds ratio (OR) 3rd tertile: 1.73 (95% confidence interval (95% CI): 1.05-2.87), P for trend ¼ 0.050), the effect being stronger in men (2nd tertile: OR ¼ 1.66, 3rd tertile: OR ¼ 2.51) than in women (2nd tertile: OR ¼ 0.91; 3rd tertile: OR ¼ 1.47). The dietary intake of antioxidants and their main food sources had no effect on asthma risk. Conclusions: In summary, the present results provide evidence that even in adulthood a high margarine intake increases the risk of clinical onset of asthma. Whether oleic acid may serve as a proxy for margarine-derived trans-fatty acids (C18:1 t9) remains to be clarified.

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“…According to some reports cholesterol has no association with the pathogenesis of asthma [50,51]. However, few workers have shown that cholesterol level is elevated in asthmatic patients and can help to evaluate the effect of treatment [52,53].…”

Section: Insights In Chest Diseasesmentioning

confidence: 99%

Hematological and Biochemical Profile of Patients Suffering from Non-Atopic Asthma

Ejaz¹,

Nasim²,

Ashraf³

et al. 2017

Insights Chest Dis

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Background: The prevalence rate of asthma is increasing at an alarming rate worldwide and number of patients with asthma is projected to reach 100 million by 2025. Few tests are being used for diagnosis of asthma, but at present no established biomarker is available which may be used for diagnosis and prognosis of asthma. Main aim of this study was to investigate the potential of routine hematological and biochemical parameters as reliable diagnostic biomarker(s) of asthma.

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Intake of unsaturated fatty acids and HDL cholesterol levels are associated with manifestations of atopy in adults

Abstract: There is indication that HDL cholesterol also plays a role in the complex interaction of fat intake, metabolism and the manifestation of atopy in adults. These findings may contribute to the understanding of time trends and regional differences of allergies.

Cited by 64 publications

References 23 publications

Serum Apolipoprotein A-I and Large High-Density Lipoprotein Particles Are Positively Correlated with FEV₁ in Atopic Asthma

Serum Apolipoprotein A-I and Large High-Density Lipoprotein Particles Are Positively Correlated with FEV₁ in Atopic Asthma

Dietary intake of fatty acids, antioxidants and selected food groups and asthma in adults

Hematological and Biochemical Profile of Patients Suffering from Non-Atopic Asthma

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Intake of unsaturated fatty acids and HDL cholesterol levels are associated with manifestations of atopy in adults

Abstract: There is indication that HDL cholesterol also plays a role in the complex interaction of fat intake, metabolism and the manifestation of atopy in adults. These findings may contribute to the understanding of time trends and regional differences of allergies.

Cited by 64 publications

References 23 publications

Serum Apolipoprotein A-I and Large High-Density Lipoprotein Particles Are Positively Correlated with FEV1 in Atopic Asthma

Serum Apolipoprotein A-I and Large High-Density Lipoprotein Particles Are Positively Correlated with FEV1 in Atopic Asthma

Dietary intake of fatty acids, antioxidants and selected food groups and asthma in adults

Hematological and Biochemical Profile of Patients Suffering from Non-Atopic Asthma

Contact Info

Product

Resources

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Serum Apolipoprotein A-I and Large High-Density Lipoprotein Particles Are Positively Correlated with FEV₁ in Atopic Asthma

Serum Apolipoprotein A-I and Large High-Density Lipoprotein Particles Are Positively Correlated with FEV₁ in Atopic Asthma