Intanza^®9 µg intradermal seasonal influenza vaccine for adults 18 to 59 years of age

Intradermal vaccination using the novel microneedle device MicronJet600: Past, present, and future

“…In its Intanza9 version, the 1.5 mm mini-needle demonstrated relative dose-sparing, at least non-inferior immunogenicity to standard unadjuvanted influenza vaccines, and high acceptability. [102][103][104] Another licensed ID vaccine delivery device that may have been used with the largest number of vaccine types is a disposable hollow microneedle (<1 mm) device known as the MicronJet600 TM , which is the focus of this review. The MicronJet600 has 3 pyramid-shaped microneedles of 0.6 mm (600 mm) length ( Fig.…”

Intradermal vaccination for infants and children

“…The dose-sparing effect of ID vaccines 3 has been confirmed for various vaccines, including those for trivalent inactivated influenza virus, [13][14][15][16][17][18][19] inactivated poliovirus, 20, 21 rabies, 22-26 yellow fever 27 , and modified vaccinia Ankara. 28 In contrast, far fewer studies have evaluated ID vaccination in infants and children than in adults, even though infants and children require more vaccines to ensure protection against VPD, and need a greater number of vaccines that require multiple dosing.…”

Skin thickness in young infants and adolescents: Applications for intradermal vaccination

“…As compared with a standard IM influenza vaccine, the ID influenza vaccine Intanza ® , licensed in 2009, had a dose-sparing effect and superior immunogenicity [8]. Intanza ® has two approved antigen dosages: 15 g per strain for adults older than 60 years (identical to the standard IM administration dosage, which induces superior immunogenicity in the elderly) [13] and a reduced standard dosage of 9 g, which achieved non-inferior immunogenicity in adults aged 18-59 years [14]. The WHO reported that an ID rabies vaccine for post-exposure prophylaxis was equally safe and immunogenic with 20-40% less volume and cost as compared with an IM regimen and recommended ID vaccination in all places where rabies vaccines were in short supply [15].…”