Integra Bilayer Matrix Wound Dressing Closure of Large Periorbital Traumatic Wound

Abstract

We report the first use of the Integra Bilayer Matrix Wound Dressing (Integra LifeSciences Corp), a collagen sheet with glycosaminoglycans and a silicone layer, in an innovative reconstruction approach to devastating traumatic tissue loss in the periocular area. A 36-year-old woman was involved in a motor vehicle crash with a resultant large defect from the medial canthus to the temporal fossa and from the pretarsal skin to the brow. There was denudation of skin and soft tissue to the bone at the superolateral orbital apex. The severity of tissue loss precluded placement of an autograft or allograft; thus, a skin substitute was instead used, with a successful reconstructive outcome. Application of the newer bioengineered skin products for full-thickness skin wounds should be considered for reconstruction of the periocular area.

A bilayer composite composed of TiO2-incorporated electrospun chitosan membrane and human extracellular matrix sheet as a wound dressing

“…However, these matrices have still some drawbacks, including cost-related concerns, infection risks, and temporary coverage. [4,5] We designed a bilayer composite composed of TiO 2 -incorporated chitosan membrane (epidermal layer) and ECM sheet (dermal layer) as a wound dressing. Chitosan is a well-known biopolymer that possesses biocompatibility, biodegradability, and hemostatic and antibacterial activity; it can also be processed into gels, nanofibers, beads, micro-/nanoparticles, and sponge forms.…”

Reconstruction of scalp defects with exposed bone after surgical treatment of basal cell carcinoma: the use of a bilayer matrix wound dressing

“…We present an unusual technique of reconstruction of surgical wounds of the scalp with a single procedure use of newer bioengineered bilayer skin product (BMWD). It is an advanced wound care device indicated for the management of different types of wounds (pathologic ulcers, surgical and traumatic wounds, burns and intrauterine large soft tissue defects) .…”

“…Consequently, the scaffold is gradually absorbed and substituted with collagen produced from the patient's own cells. After 21 days, the silicone layer is usually removed and within 3–8 weeks, the migration of epidermal cells from the edges completes wound closure . Especially for large defects, a delayed thin/ultra thin skin autograft is routinely applied over the neodermis to complete wound closure.…”

“…In case of full‐thickness scalp injury down to the periosteum without vascularized surgical bed, the combined use of BMWD followed by skin grafting has proven to be an effective and simple method, especially in the elderly population . BMWD provides higher quality coverage over wounds with exposed bone, decreases operative time and morbidity, minimizes secondary deformity, and, during postoperative course, it can be easily managed in the outpatient setting .…”

Bi-layered Nanofibers Membrane Loaded with Titanium Oxide and Tetracycline as Controlled Drug Delivery System for Wound Dressing Applications

“…The scaffolds provide a barrier against bacterial infection and water loss, and also have a tridimensional structure with interconnected pores in wounds. However, these scaffolds still have some disadvantages, including cost-associated concerns, infection risks factors, and temporary coverage [4,5].…”