This special issue of the Journal Mathematical Methods in the Applied Sciences on the topic of Modelling, Analysis, and Applications is devoted to the development of mathematical modelling, analysis, and applications, from theoretical and numerical perspectives, involving different applied sciences and engineering. It collects invited contributions, from selected quality full papers submitted to the International Conference on Mathematical Analysis and Applications in Science and Engineering (ICMA2SC2022). The conference took place in Porto, Portugal in 27–29 June 2022 (https://www.isep.ipp.pt/Page/ViewPage/ICMASC).