We are interested in nonlocal eikonal equations describing the evolution of interfaces moving with a nonlocal, non-monotone velocity. For these equations, only the existence of global-in-time weak solutions is available in some particular cases. In this paper, we propose a new approach for proving uniqueness of the solution when the front is expanding. This approach simplifies and extends existing results for dislocation dynamics. It also provides the first uniqueness result for a Fitzhugh-Nagumo system. The key ingredients are some new perimeter estimates for the evolving fronts as well as some uniform interior cone property for these fronts.