Integrated 3D-printed reactionware for chemical synthesis and analysis

Symes, Mark D.; Kitson, Philip J.; Yan, Jun; Richmond, Craig J.; Cooper, Geoffrey J. T.; Bowman, Richard; Vilbrandt, Turlif; Cronin, Leroy

doi:10.1038/nchem.1313

Cited by 565 publications

(378 citation statements)

References 29 publications

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“…24 For example, Kitson et al [25][26][27] demonstrated fluidic devices 3D printed by extruding plastic through a heated nozzle. However, this fabrication method is inherently unable to produce feature sizes and flow channel dimensions needed for microfluidic (as opposed to macrofluidic or millifluidic) device fabrication.…”

Section: Microfluidicsmentioning

confidence: 99%

3D printed microfluidic devices with integrated valves

2015

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We report the successful fabrication and testing of 3D printed microfluidic devices with integrated membrane-based valves. Fabrication is performed with a low-cost commercially available stereolithographic 3D printer. Horizontal microfluidic channels with designed rectangular cross sectional dimensions as small as 350 μm wide and 250 μm tall are printed with 100% yield, as are cylindrical vertical microfluidic channels with 350 μm designed (210 μm actual) diameters. Based on our previous work [Rogers et al., Anal. Chem. 83, 6418 (2011)], we use a custom resin formulation tailored for low non-specific protein adsorption. Valves are fabricated with a membrane consisting of a single build layer. The fluid pressure required to open a closed valve is the same as the control pressure holding the valve closed. 3D printed valves are successfully demonstrated for up to 800 actuations.

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Section: Microfluidicsmentioning

confidence: 99%

3D printed microfluidic devices with integrated valves

2015

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“…The explosion of interest in 3D printing in recent years has extended to science; the technique has been exploited by an increasing number of researchers to address cuttingedge research needs through custom chemical reactionware, 10 open-source optomechanical components 11 and vortex chambers, 12 among many examples.…”

Section: D Printed Hingesmentioning

confidence: 99%

A one-piece 3D printed flexure translation stage for open-source microscopy

Sharkey

Foo

Kabla

et al. 2016

Review of Scientific Instruments

Self Cite

135

116

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Open source hardware has the potential to revolutionise the way we build scientific instruments; with the advent of readily-available 3D printers, mechanical designs can now be shared, improved and replicated faster and more easily than ever before. However, printed parts are typically plastic and often perform poorly compared to traditionally machined mechanisms. We have overcome many of the limitations of 3D printed mechanisms by exploiting the compliance of the plastic to produce a monolithic 3D printed flexure translation stage, capable of sub-micron-scale motion over a range of 8×8×4 mm. This requires minimal post-print cleanup, and can be automated with readily-available stepper motors. The resulting plastic composite structure is very stiff and exhibits remarkably low drift, moving less than 20 µm over the course of a week, without temperature stabilisation. This enables us to construct a miniature microscope with excellent mechanical stability, perfect for timelapse measurements in situ in an incubator or fume hood. The ease of manufacture lends itself to use in containment facilities where disposability is advantageous, and to experiments requiring many microscopes in parallel. High performance mechanisms based on printed flexures need not be limited to microscopy, and we anticipate their use in other devices both within the laboratory and beyond.

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“…Gradient structures and novel composite materials can be printed by selectively patterning different inks. [5][6][7] These processing advantages are particularly useful for the construction of complex structures where spatially varying mechanical properties are likely needed.…”

Section: Introductionmentioning

confidence: 99%

Three-Dimensional Printing Fiber Reinforced Hydrogel Composites

Bakarich

Gorkin

Panhuis

et al. 2014

ACS Appl. Mater. Interfaces

172

115

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An additive manufacturing process that combines digital modeling and 3D printing was used to prepare fiber reinforced hydrogels in a single-step process. The composite materials were fabricated by selectively pattering a combination of alginate/acrylamide gel precursor solution and an epoxy based UV-curable adhesive (Emax 904 Gel-SC) with an extrusion printer. UV irradiation was used to cure the two inks into a single composite material. Spatial control of fiber distribution within the digital models allowed for the fabrication of a series of materials with a spectrum of swelling behavior and mechanical properties with physical characteristics ranging from soft and wet to hard and dry. A comparison with the "rule of mixtures" was used to show that the swollen composite materials adhere to standard composite theory. A prototype meniscus cartilage was prepared to illustrate the potential application in bioengineering. ABSTRACTAn additive manufacturing process that combines digital modeling and 3D printing was used to prepare fibre reinforced hydrogels in a single-step process. The composite materials were fabricated by selectively pattering a combination of alginate/acrylamide gel precursor solution and an epoxy based UV-curable adhesive (Emax 904 Gel-SC) with an extrusion printer. UV irradiation was used to cure the two inks into a single composite material. Spatial control of fibre distribution within the digital models allowed for the fabrication of a series of materials with a spectrum of swelling behaviour and mechanical properties with physical characteristics ranging from soft and wet to hard and dry. A comparison with the 'rule of mixtures' was used to show that the swollen composite materials adhere to standard composite theory. A prototype meniscus cartilage was prepared to illustrate the potential application in bioengineering.

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Integrated 3D-printed reactionware for chemical synthesis and analysis

Cited by 565 publications

References 29 publications

3D printed microfluidic devices with integrated valves

3D printed microfluidic devices with integrated valves

A one-piece 3D printed flexure translation stage for open-source microscopy

Three-Dimensional Printing Fiber Reinforced Hydrogel Composites

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