Integrated analysis of miRNA‐mRNA networks reveals a strong anti‐skin cancer signature in vitiligo epidermis

Singh, Archana; Gupta, Aayush; Chowdhary, Manish; Brahmbhatt, Hemang Dineshbhai

doi:10.1111/exd.14317

Cited by 8 publications

(3 citation statements)

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“…The level of miR‐328 was standardized to U6, and the gene level of the detection results was calculated according to the 2 −∆∆Ct . The specific operation is carried out according to the method of Archana et al 33 …”

Section: Methodsmentioning

confidence: 99%

Combination of 308‐nm excimer laser and piperine promotes melanocyte proliferation, migration, and melanin content production via the miR‐328/SFRP1 axis

Wu,

Zhang,

et al. 2024

Photoderm Photoimm Photomed

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ObjectiveBoth piperine and a 308‐nm excimer laser have significant curative effects on vitiligo. This study mainly explored the molecular mechanism of a 308‐nm excimer combined with piperine in regulating melanocyte proliferation.MethodsEpidermal melanocytes were cultured in piperine solution, and the cells were irradiated by an XTRAC excimer laser treatment system at 308‐nm output monochromatic light. Quantitative real‐time polymerase chain reaction (qRT–PCR) and Western blot were for detecting the expression levels of genes or proteins. The 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide (MTT) and Transwell method was for assessing cell viability and migration capacity. The content of melanin was also detected.ResultsThe combination of the 308‐nm excimer laser and piperine enhanced the cell proliferation, migration, and melanin production of melanocytes and upregulated the level of miR‐328, and restraint of miR‐328 reversed the influence of the 308‐nm excimer laser and piperine. Secreted frizzled‐related protein 1 (SFRP1) is a direct target gene of miR‐328, and miR‐328 can inhibit the expression of SFRP1 and elevate the protein level of the Wnt/β‐catenin signaling pathway.ConclusionThe 308‐nm excimer laser combined with piperine may be more efficient than piperine alone in the remedy of vitiligo, and the miR‐328/SFRP1 and Wnt/β‐catenin pathways are participated in the proliferation, migration, and melanin synthesis of melanocytes.

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Section: Methodsmentioning

confidence: 99%

Combination of 308‐nm excimer laser and piperine promotes melanocyte proliferation, migration, and melanin content production via the miR‐328/SFRP1 axis

Wu,

Zhang,

et al. 2024

Photoderm Photoimm Photomed

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“…RNA-based immunomodulation of cancers is now being explored to enhance the therapeutic efficacy of existing immunotherapy. Many modalities are used, such as regulating cellular function through mRNA, siRNA, or stimulating immune components, specifically TLRs or cytosolic RIG-I [ 81 , 138 , 139 ]. RNA-based immunomodulation can be achieved to full potency only through nanoparticle encapsulated delivery systems, which facilitate overcoming ineffective target cell delivery, degradation through RNases, cross membrane diffusion difficulties, etc.…”

Section: Nanoimmunotherapeutics and Precision Medicine In Skin Cancer...mentioning

confidence: 99%

Enhancing Skin Cancer Immunotheranostics and Precision Medicine through Functionalized Nanomodulators and Nanosensors: Recent Development and Prospects

Farhana

2023

IJMS

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Skin cancers, especially melanomas, present a formidable diagnostic and therapeutic challenge to the scientific community. Currently, the incidence of melanomas shows a high increase worldwide. Traditional therapeutics are limited to stalling or reversing malignant proliferation, increased metastasis, or rapid recurrence. Nonetheless, the advent of immunotherapy has led to a paradigm shift in treating skin cancers. Many state-of-art immunotherapeutic techniques, namely, active vaccination, chimeric antigen receptors, adoptive T-cell transfer, and immune checkpoint blockers, have achieved a considerable increase in survival rates. Despite its promising outcomes, current immunotherapy is still limited in its efficacy. Newer modalities are now being explored, and significant progress is made by integrating cancer immunotherapy with modular nanotechnology platforms to enhance its therapeutic efficacy and diagnostics. Research on targeting skin cancers with nanomaterial-based techniques has been much more recent than other cancers. Current investigations using nanomaterial-mediated targeting of nonmelanoma and melanoma cancers are directed at augmenting drug delivery and immunomodulation of skin cancers to induce a robust anticancer response and minimize toxic effects. Many novel nanomaterial formulations are being discovered, and clinical trials are underway to explore their efficacy in targeting skin cancers through functionalization or drug encapsulation. The focus of this review rivets on theranostic nanomaterials that can modulate immune mechanisms toward protective, therapeutic, or diagnostic approaches for skin cancers. The recent breakthroughs in nanomaterial-based immunotherapeutic modulation of skin cancer types and diagnostic potentials in personalized immunotherapies are discussed.

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“…Interestingly, vitiligo skin has decreased incidence of non-melanoma skin cancer, which has been linked to the expression profile of miRs, which target pro-tumorigenic factors in vitiligo skin. 49…”

Section: S K In C An Cermentioning

confidence: 99%

Skin epigenetics

Andersen

Millar

2021

Experimental Dermatology

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The study of skin epigenetics is essential in understanding the mechanisms involved in cutaneous development, homeostasis and disease, and holds great promise for the identification of new therapeutic approaches to both common and rare diseases of the skin.In the current issue of Experimental Dermatology, we highlight this critically important area of research and the most exciting findings by providing a collection of state-of-the-art research articles and critical reviews of the recent literature.

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Integrated analysis of miRNA‐mRNA networks reveals a strong anti‐skin cancer signature in vitiligo epidermis

Cited by 8 publications

References 50 publications

Combination of 308‐nm excimer laser and piperine promotes melanocyte proliferation, migration, and melanin content production via the miR‐328/SFRP1 axis

Combination of 308‐nm excimer laser and piperine promotes melanocyte proliferation, migration, and melanin content production via the miR‐328/SFRP1 axis

Enhancing Skin Cancer Immunotheranostics and Precision Medicine through Functionalized Nanomodulators and Nanosensors: Recent Development and Prospects

Skin epigenetics

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