The tropical ecosystem had high biomass productivity but still less in economic values. Integrated Bio-cycle Farming System (IBFS) was an alternative system that harmoniously combines agricultural sectors (agriculture, forestry, animal husbandry, fishery, plantation estate, horticulture) and non-agricultural aspects (industry, household, infrastructure, the marketplace) on integrated ecological management. The key characteristics of IBFS developed in UGM University Farm were (i) an integration of agriculture and non-agriculture sector, (ii) value of environment, esthetics and economics, (iii) rotation and diversity of plants, (iv) artificial and functional biotechnology, (v) management of closed organic cycle, (vi) ecosystem health management, (vii) agropolitan concept, (viii) specific management of plant and (ix) holistic and integrated system. The management of cycle of energy, organic matter and carbon, water, nutrient, production, crop, money conducted through 9R (reuse, reduce, recycle, refill, replace, repair, replant, rebuild, reward) to obtain optimal benefits for global environment and livelihood. The system had a sustainable multifunction and multi-product (food, feed, fuel, fiber, fertilizer, biopharma, water, energy, oxygen, edutainment, eco-tourism). They would meet the expected basic need for daily-, monthly-, yearly- and decade’s income at short-, medium- and long- term periods. IBFS was a good prospect for sustainable economic, environmental, and socio-culture aspects.