Integrated Direct DNA/Protein Patterning and Microfabrication by Focused Ion Beam Milling

Jiang, Jie; Li, Xiaomin; Mak, Wing Cheung; Trau, Dieter

doi:10.1002/adma.200701415

Cited by 17 publications

(16 citation statements)

References 41 publications

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“… 8 , 9 In recent years, advances in the areas of microfabrication and nanofabrication have influenced various techniques used to deliver proteins to underlying surfaces. Methods developed so far to localize proteins on surfaces include manual and robotic delivery, 10 microcontact printing, 11 , 12 capillary force lithography, 13 imprint and nanoimprint lithography, 14 , 15 particle lithography, 16 microfluidic channel networks, 17 focused-ion-beam patterning, 18 inkjet deposition, 19 and dip-pen and related scanning probe lithography. 20 , 21 Table 1 classifies these techniques on the basis of the pattern size and transfer approach to partitioning proteins on surfaces.…”

Section: Methods Of Assembling Proteins On Surfacesmentioning

confidence: 99%

“…In the past, various processes such as UV lithography, microcontact printing, and focused ion beam milling have been employed in order to create chemically defined surface areas for localized protein adsorption on solid surfaces. 11 , 12 , 18 Self-assembled monolayers have also been used for the chemical patterning of substrates for subsequent protein adsorption. 29 For the physical modification of solid substrates ahead of protein deposition, alterations to delineate the surface areas are performed by laser ablation, 30 reactive ion etching, 31 and sputtering.…”

Section: Controlled Nanoscale Protein Adsorption Through Self-assemblmentioning

confidence: 99%

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Fundamentals of Nanoscale Polymer–Protein Interactions and Potential Contributions to Solid-State Nanobioarrays

Hahm

2014

Langmuir

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Protein adsorption onto polymer surfaces is a very complex, ubiquitous, and integrated process, impacting essential areas of food processing and packaging, health devices, diagnostic tools, and medical products. The nature of protein–surface interactions is becoming much more complicated with continuous efforts toward miniaturization, especially for the development of highly compact protein detection and diagnostic devices. A large body of literature reports on protein adsorption from the perspective of ensemble-averaged behavior on macroscopic, chemically homogeneous, polymeric surfaces. However, protein–surface interactions governing the nanoscale size regime may not be effectively inferred from their macroscopic and microscopic characteristics. Recently, research efforts have been made to produce periodically arranged, nanoscopic protein patterns on diblock copolymer surfaces solely through self-assembly. Intriguing protein adsorption phenomena are directly probed on the individual biomolecule level for a fundamental understanding of protein adsorption on nanoscale surfaces exhibiting varying degrees of chemical heterogeneity. Insight gained from protein assembly on diblock copolymers can be effectively used to control the surface density, conformation, orientation, and biofunctionality of prebound proteins in highly miniaturized applications, now approaching the nanoscale. This feature article will highlight recent experimental and theoretical advances made on these fronts while focusing on single-biomolecule-level investigations of protein adsorption behavior combined with surface chemical heterogeneity on the length scale commensurate with a single protein. This article will also address advantages and challenges of the self-assembly-driven patterning technology used to produce protein nanoarrays and its implications for ultrahigh density, functional, and quantifiable protein detection in a highly miniaturized format.

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Section: Methods Of Assembling Proteins On Surfacesmentioning

confidence: 99%

Section: Controlled Nanoscale Protein Adsorption Through Self-assemblmentioning

confidence: 99%

Fundamentals of Nanoscale Polymer–Protein Interactions and Potential Contributions to Solid-State Nanobioarrays

Hahm

2014

Langmuir

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“…Although e-beam lithography and focused ion-beam lithography are able to create a large variety of nanopatterns [290][291][292][293], the cost and time to write them are disadvantageous when compared to the parallel nanopatterning methods described in section 4.1. These important disadvantages have seen the use of these two nanopatterning techniques limited.…”

Section: Serial Nanopatterning Methodsmentioning

confidence: 99%

Nanoscale Biosensors and Biochips

Leifert

Glatz

Bailey

et al. 2009

Annual Review of Nano Research

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“…Nanostructures used in near field optics [1][2][3] material science [4,5], and biological applications [6,7] can easily be realised using Focused Ion Beam (FIB) technique. In this work three applications developed in our laboratories are presented in order to highlight the versatility of FIB technique.…”

Section: Introductionmentioning

confidence: 99%