Aim: To carry out a systematic review of the environmental regulation applicable to emerging pollutants at the international level, with a special interest in Mexico. Methods: The search for articles and documents was carried out under the criteria of the PRISMA statement (Preferred Reporting Items for Systematic Reviews and Meta-Analysis), in databases such as Pub-Med, Scopus, Science Direct, Jane’s, Dimensions, Google Scholar, as well as the Comprehensive System of Standards and Evaluation of the Ministry of the Interior of Mexico. Results: 3089 documents were reviewed, and considering the inclusion, exclusion, and quality criteria, 2 tables were constructed, the first with 24 scientific articles and the second with 7 Mexican standards. Conclusion: The regulation of emerging pollutants is a critical issue that must involve all sectors (for example, political, economic, social, and environmental). For this, it is necessary to coordinate the government, society and consider the experiences of other countries for its implementation. It was also identified that the issues of access to information and education programs have a significant impact on compliance with environmental regulations and that there is little scientific evidence on this matter.