Integrated immune monitoring of HCMV infection in pregnant women with complications and its association with adverse pregnancy outcomes

Palav, Harsha; Bhonde, Gauri; Padwal, Varsha; Velhal, Shilpa; Pereira, J Giral Y; Singh, Amit Kumar; Ghosh, Sayantani; Karandikar, Kalyani; Satoskar, Purnima; Bhor, Vikrant M.; Patel, Vainav

doi:10.1016/j.micpath.2023.106109

Cited by 5 publications

(3 citation statements)

References 46 publications

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“…During the first months following primary infection, antibodies of the IgG type with low avidity are produced. Those produced by 4-6 months after infection have high avidity [9][10][11]. Since we did not measured the IgM CMV value in our study, we cannot state if the patients with undetectable or borderline (low) CMV avidity have recent infection or reinfection.…”

Section: Igg CMV Cmv Avidity Hiv Viremia and Cd4 Values Correlations ...mentioning

confidence: 77%

CMV and HIV Coinfection in Women from a Region in Eastern Europe

Halichidis,

Aschie,

Cozaru

et al. 2023

JPM

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(1) Background: Human cytomegalovirus (CMV) infection is one of the most frequent opportunistic infections in immunosuppressed patients. Romania has one of the highest incidences of patients living with human immunodeficiency virus (HIV) which determines an immunosuppressive state. The aim of this study was to establish the prevalence of CMV infection among women living with HIV in Southeastern Romania and also to evaluate and correlate antiretroviral therapy (ART) with CD4 level and CMV disease evolution. (2) Methods: Seventy women living with HIV from Southeastern Romania were screened for CMV infection using antigen quantification. Of these, 50 were included in the study. First, the patients filled out a questionnaire regarding social conditions and other associated diseases. Then, we explored the statistical correlations between the data and HIV status, CD4+ cell counts, viral load, and antiretroviral therapy (ART). (3) Results: Median age of the patients was 33 years. Twenty-nine cases were diagnosed with HIV after sexual life beginning and 21 before. Most of the patients had a CD4 level over 200 cells/µL. ART duration in the CD4 under 200 cells/µL group was a bit longer than that in the CD4 over 200 cells/µL group. Forty-one patients had undetectable viremia. CD4 average value in the lot of patients with undetectable viremia was 704.71 cells/µL and in the lot with detectable viremia was 452.44 cells/µL. Viremia values correlated negatively with CD4 level. A positive correlation between IgG CMV values and ART therapy length was identified. A negative significant correlation between values of IgG CMV and values of CD4 was identified. CD4 value correlated negatively with IgG CMV values and with CMV avidity. (4) Conclusions: IgG CMV values had a weak positive correlation with ART therapy length, and a negative statistically significant correlation with values of CD4. CMV avidity has a negative correlation with CD4 value.

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Section: Igg CMV Cmv Avidity Hiv Viremia and Cd4 Values Correlations ...mentioning

confidence: 77%

CMV and HIV Coinfection in Women from a Region in Eastern Europe

Halichidis,

Aschie,

Cozaru

et al. 2023

JPM

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“…Scientific database querying identified only a few studies that analyzed the impact of latent CMV infection on the rate of previous spontaneous abortion [19,[49][50][51]54] or pregnancy complications such as pregnancy-induced hypertensive disease [55][56][57][58][60][61][62][63][64][65][66][67], HELLP syndrome [56], IUGR [68], intrauterine fetal death [68], or neonatal features at birth [68].…”

Section: Discussionmentioning

confidence: 99%

“…Most studies analyzed the effect of a primary CMV infection throughout the course of pregnancy or on the fetus [46,47]. Only a few studies describe the impact of latent CMV infection [48,49]. These latter studies analyzed the association of latent CMV infection with the occurrence of recurrent pregnancy loss [50][51][52][53][54] and the prevalence of pregnancy complication such as HELLP syndrome [55], preeclampsia [55][56][57][58][59][60][61][62][63][64][65][66][67], fetal death [68], and low birth weight [68].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Latent Cytomegalovirus Infection on Spontaneous Abortion History and Pregnancy Outcomes in Romanian Pregnant Women

Mocanu,

Stoian,

Daescu

et al. 2024

Microorganisms

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Cytomegalovirus (CMV), a DNA virus that belongs to the Orthoherpesviridae family, infects 40–100% of people. Primary/non-primary CMV infection during pregnancy could cause fetal disabilities. After primary infection, CMV causes a latent infection and resides in cells of the myeloid compartment (CD34+, monocytes). Few studies have analyzed the impact of latent CMV infections on miscarriage history, pregnancy complications, and neonatal outcomes. Methods: Serum samples from 806 pregnant women (28.29 ± 4.50 years old) who came for a consultation at the Timisoara Clinical Emergency City Hospital between 2008 and 2010 were tested for anti-CMV IgM/IgG antibodies, and data about demography, obstetrical history, pregnancy complications, birth, and neonate were collected. The data were compared between the groups with and without latent CMV infection, and statistical significance was calculated. Results: We did not find a difference regarding cesarean section (OR = 0.916, p = 0.856), placental abruption (OR = 1.004, p = 1.00), pregnancy-induced hypertension rate (OR = 1.078, p = 1.00), secondary sex ratio (0.882, p = 0.857), APGAR score (p = 0.225), gestational age at birth (p = 0.434), or birth weight (p = 0.365). A borderline significant difference was found regarding the presence of miscarriage history: OR = 8.467, p = 0.051. Conclusions: The presence of latent CMV infection does not affect the likelihood of complications in healthy women. A borderline significantly higher prevalence of miscarriage history was found in women with latent CMV infection.

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Comparative immune profiling in survivors of the 2023 Nipah outbreak in Kerala state, India

Sahay,

Palav,

Shete

et al. 2024

Journal of Medical Virology

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Immune profiling of Nipah virus (NiV) infection survivors is essential for advancing our understanding of NiV pathogenesis, improving diagnostic and therapeutic strategies, and guiding public health efforts to prevent future outbreaks. There is currently limited data available on the immune response to NiV infection. We aimed to elucidate the specific immune mechanisms involved in protection against NiV infection by analyzing the immune profiles of survivors of the Nipah outbreak in Kerala, India 2023. Immune cell populations were quantified and compared between survivors (up to 4 months post onset day of illness) and healthy controls. Statistical analysis was performed to explore associations between immune profiles and clinical outcomes. Immune signatures common to all three cases were: a heretofore undescribed persistent lymphopenia including the CD4+ Treg compartment with the relative expansion of memory Tregs; trends indicative of global leukopenic modulation were observed in monocytes and granulocytes including an expansion of putatively immunosuppressive low‐density granulocytes described recently in the context of severe COVID‐19; altered mucosal homing with respect to integrin beta‐7 (ITGB7) expressing subsets; increased mobilization of activated T‐cells (CD4+ and CD8+) and plasmablasts in the early phase of infection. Comparative analysis based on clinical presentation and outcome yielded lower initial viremia, increased activated T‐cell responses, expanded plasmablasts, and restoration of ITGB7 expressing CD8+ T‐cells as possible protective signatures. This longitudinal study delineates putative protective signatures associated with milder NiV disease. It emphasizes the need for the development of immunotherapeutic interventions such as monoclonal antibodies to blunt early viremia and ameliorate pathogenesis.

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Integrated immune monitoring of HCMV infection in pregnant women with complications and its association with adverse pregnancy outcomes

Cited by 5 publications

References 46 publications

CMV and HIV Coinfection in Women from a Region in Eastern Europe

CMV and HIV Coinfection in Women from a Region in Eastern Europe

The Impact of Latent Cytomegalovirus Infection on Spontaneous Abortion History and Pregnancy Outcomes in Romanian Pregnant Women

Comparative immune profiling in survivors of the 2023 Nipah outbreak in Kerala state, India

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