Integrated microfluidic systems with an immunosensor modified with carbon nanotubes for detection of prostate specific antigen (PSA) in human serum samples

Panini, Nancy V.; Messina, Germán A.; Salinas, Eloy; Fernández, Héctor; Raba, Julio

doi:10.1016/j.bios.2007.11.003

Cited by 116 publications

(66 citation statements)

References 48 publications

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“…[8][9][10][11][12][13] This platform was applied also in a capillary electrophoresis (CE) microchip. 14,15 Applications in electrophoretic systems, meanwhile, exhibit drawbacks related to interferences between the electric fields of detection and separation.…”

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confidence: 99%

Glass/PDMS hybrid microfluidic device integrating vertically aligned SWCNTs to ultrasensitive electrochemical determinations

et al. 2012

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This communication reports a promising platform for rapid, simple, direct, and ultrasensitive determination of serotonin. The method is related to integration of vertically aligned singlewalled carbon nanotubes (SWCNTs) in electrochemical microfluidic devices. The required microfabrication protocol is simple and fast. In addition, the nanomaterial influenced remarkably the obtained limit-of-detection (LOD) values. Our system achieved a LOD of 0.2 nmol L 21 for serotonin, to the best of our knowledge one of the lowest values reported in the literature.Glass/elastomer hybrid microfluidic platforms with integrated electrochemical detectors are powerful analytical tools. Their main advantages include: (i) low cost; (ii) chemical inertia; (iii) optical transparency; (iv) thermal, mechanical, and chemical stability; (v) automation capacity, and; (vi) easy microfabrication. In addition, they offer high values of reproducibility and sensitivity.

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confidence: 99%

Glass/PDMS hybrid microfluidic device integrating vertically aligned SWCNTs to ultrasensitive electrochemical determinations

et al. 2012

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“…As is well known that is important early diagnosis of cancer which death rate among men with prostate cancer is known to be high, and confirmed by the WHO datas (Panini et al, 2008). In this study, a simple and rapid determination of the PSA is designed to carry out the QCM biosensor.…”

Section: Qcm Based Biosensors Developed For Determination Of Psamentioning

confidence: 93%

Biosensors for Cancer Biomarkers

Uygun¹,

Sezgintürk²

2011

Biosensors - Emerging Materials and Applications

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“…The captured PSA alters the current that runs through the CNT giving rise to detection. [147][148][149][150][151][152][153][154][155][156][157][158][159] Electrochemiluminescence assays took advantage of this in conjugation with the nature of titanium nanotubes to achieve a low detection limit of 1 fg/mL. 160 The most popular nanomaterial is gold either as nanoparticle or as a nanopore.…”

Section: Highly Sensitive Psa Detection Through Nanotechnologymentioning

confidence: 99%

“…148,[151][152][153][154]157,[173][174][175] This trend is most likely for proof of principle of the developed bioassays because CNT is primarily used for academic purposes rather than for practical use. GNP was the second most used nanomaterial, an indicative of effort to develop more sensitive PSA detection methods in serum.…”

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confidence: 99%

Diagnosis of prostate cancer via nanotechnological approach

Kang

Jeun

Jang

et al. 2015

IJN

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Prostate cancer is one of the leading causes of cancer-related deaths among the Caucasian adult males in Europe and the USA. Currently available diagnostic strategies for patients with prostate cancer are invasive and unpleasant and have poor accuracy. Many patients have been overly or underly treated resulting in a controversy regarding the reliability of current conventional diagnostic approaches. This review discusses the state-of-the-art research in the development of novel noninvasive prostate cancer diagnostics using nanotechnology coupled with suggested diagnostic strategies for their clinical implication.

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Integrated microfluidic systems with an immunosensor modified with carbon nanotubes for detection of prostate specific antigen (PSA) in human serum samples

Cited by 116 publications

References 48 publications

Glass/PDMS hybrid microfluidic device integrating vertically aligned SWCNTs to ultrasensitive electrochemical determinations

Glass/PDMS hybrid microfluidic device integrating vertically aligned SWCNTs to ultrasensitive electrochemical determinations

Biosensors for Cancer Biomarkers

Diagnosis of prostate cancer via nanotechnological approach

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