Integrated proteo-genomic approach for early diagnosis and prognosis of cancer

Shukla, Hem D.; Mahmood, Javed; Vujašković, Željko

doi:10.1016/j.canlet.2015.08.003

Cited by 35 publications

(29 citation statements)

References 131 publications

(136 reference statements)

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“…4,5 Consequently, it is challenging to establish a universal strategy for cancer detection using conventional probes that recognize cancer-associated biomarkers. 6–8 …”

Section: Introductionmentioning

confidence: 99%

pH-Responsive fluorescent graphene quantum dots for fluorescence-guided cancer surgery and diagnosis

et al. 2017

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Cancer remains a major cause of morbidity and mortality around the world. Improved cancer treatment requires enhancing cancer diagnosis and detection. To achieve this goal, here we reported a novel imaging probe, pH-responsive fluorescent graphene quantum dots (pRF-GQDs). pRF-GQDs were prepared by electrolysis of graphite rods in sodium p-toluenesulfonate acetonitrile solution. The resulting pRF-GQDs, which have minimal toxicity, display a sharp fluorescence transition between green and blue at pH 6.8, a pH matching the acidic extracellular microenvironment in solid tumors. We found that this unique fluorescence switch property allows distinguishing tumors from normal tissues. In addition to fluorescence, pRF-GQDs also bear the upconversion photoluminescence (UCPL) property. We demonstrate that the combination of UCPL and fluorescence switch enables detecting solid tumors of different origin at an early developmental stage. Therefore, pRF-GQDs have great potential to be used as a universal probe for fluorescence-guided cancer surgery and cancer diagnosis.

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“…4,5 Consequently, it is challenging to establish a universal strategy for cancer detection using conventional probes that recognize cancer-associated biomarkers. 6–8 …”

Section: Introductionmentioning

confidence: 99%

pH-Responsive fluorescent graphene quantum dots for fluorescence-guided cancer surgery and diagnosis

et al. 2017

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“…This approach has the ability to detect altered protein variants in the database and identify somatic and germline mutations as well as copy number variations (CNVs) in altered proteins 13 . The genomic expression can predict intrinsic cellular radiosensitivity 14, 15.…”

Section: History Of Ed Treatmentmentioning

confidence: 99%

Radiation-induced erectile dysfunction: Recent advances and future directions

Mahmood

Shamah

Creed

et al. 2016

Advances in Radiation Oncology

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Prostate cancer is one of the most prevalent cancers and the second leading cause of cancer-related deaths in men in the United States. A large number of patients undergo radiation therapy (RT) as a standard care of treatment; however, RT causes erectile dysfunction (radiation-induced erectile dysfunction; RiED) because of late side effects after RT that significantly affects quality of life of prostate cancer patients. Within 5 years of RT, approximately 50% of patients could develop RiED. Based on the past and current research findings and number of publications from our group, the precise mechanism of RiED is under exploration in detail. Recent investigations have shown prostate RT induces significant morphologic arterial damage with aberrant alterations in internal pudendal arterial tone. Prostatic RT also reduces motor function in the cavernous nerve which may attribute to axonal degeneration may contributing to RiED. Furthermore, the advances in radiogenomics such as radiation induced somatic mutation identification, copy number variation and genome-wide association studies has significantly facilitated identification of biomarkers that could be used to monitoring radiation-induced late toxicity and damage to the nerves; thus, genomic- and proteomic-based biomarkers could greatly improve treatment and minimize arterial tissue and nerve damage. Further, advanced technologies such as proton beam therapy that precisely target tumor and significantly reduce off-target damage to vital organs and healthy tissues. In this review, we summarize recent advances in RiED research and novel treatment modalities for RiED. We also discuss the possible molecular mechanism involved in the development of RiED in prostate cancer patients. Further, we discuss various readily available methods as well as novel strategies such as stem cell therapies, shockwave therapy, nerve grafting with tissue engineering, and nutritional supplementations might be used to mitigate or cure sexual dysfunction following radiation treatment.

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“…Despite the advancement and innovative diagnostic techniques, most cancers are still detected at late or advanced stage, consequently elevating the mortality rates (Shukla et al, 2015). Early diagnosis and treatment, preferably during the precancerous phase, facilitates improved treatment response and survival rate.…”

Section: Cancer Diagnosismentioning

confidence: 99%

“…Hence, it is inevitable to discover novel biomarkers for the early detection of cancer. Recently, advanced genomic technologies like digital PCR, NextGen sequencing, and cfDNA technology have shown great potential; for instance, transcriptomic analysis, copy number variant, and methylation data from the Cancer Genome Atlas (Shukla et al, 2015). Moreover, the use of multiple proteomic and genomic biomarkers rather than a single gene or protein can greatly revolutionize the diagnostic approach (Shukla et al, 2015).…”

Section: Cancer Diagnosismentioning

confidence: 99%

“…Recently, advanced genomic technologies like digital PCR, NextGen sequencing, and cfDNA technology have shown great potential; for instance, transcriptomic analysis, copy number variant, and methylation data from the Cancer Genome Atlas (Shukla et al, 2015). Moreover, the use of multiple proteomic and genomic biomarkers rather than a single gene or protein can greatly revolutionize the diagnostic approach (Shukla et al, 2015). Interestingly, use of magnetic nanoparticles as a part of in vivo cancer diagnosis has also drawn much attention mostly due to its suitable physical properties, magnetic susceptibility, biocompatibility, stability, etc.…”

Section: Cancer Diagnosismentioning

confidence: 99%

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