2021
DOI: 10.3389/fgene.2021.680331
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Integrated Transcriptome and Multiple Activated Pathways in Endometrial Cancer

Abstract: Because the incidence of endometrial cancer is notably increasing worldwide, it has become the leading gynecologic cancer in the United States. Standard treatment results in the loss of reproductive function in women of childbearing age. Furthermore, advanced cancer stages are associated with poor overall survival. The aim of this study was to explore the abnormal expression profile of genes during the development of endometrial cancer, which is essential to provide a better understanding of the mechanisms inv… Show more

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Cited by 2 publications
(2 citation statements)
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“…Consistent with the hallmark study of Bui [16] and the recent study of Coopes [34], we showed that WNT4 gene expression was significantly decreased in EC compared to the control. Furthermore, our study is consistent with the data showing that WNT4 is a down-regulated gene in EC, which was detected using microarray [35] and next-generation transcriptome sequencing technology [36]. A novelty of our approach is the comparison of WNT4 gene expression between control and EC samples, taking into account not only grade but also other cancer features.…”
Section: Discussionsupporting
confidence: 89%
“…Consistent with the hallmark study of Bui [16] and the recent study of Coopes [34], we showed that WNT4 gene expression was significantly decreased in EC compared to the control. Furthermore, our study is consistent with the data showing that WNT4 is a down-regulated gene in EC, which was detected using microarray [35] and next-generation transcriptome sequencing technology [36]. A novelty of our approach is the comparison of WNT4 gene expression between control and EC samples, taking into account not only grade but also other cancer features.…”
Section: Discussionsupporting
confidence: 89%
“…Furthermore, alterations were observed in the TGF-b signaling pathway as well as the PI3K-Akt and estrogen pathways among others. These findings contribute to a deeper understanding of the underlying mechanisms driving endometrial cancer (12). Additionally, transcriptome analysis conducted by Ren et al revealed that GPNMB serves as a promising target in gastric cancer and exerts a crucial positive regulatory role in tumor progression.…”
Section: Introductionmentioning
confidence: 85%