D espite important advances in primary prevention, atherosclerosis remains the leading cause of death in developed societies.1 In addition to risk factors such as hypertension, diabetes mellitus, tobacco use and dyslipidemia, less traditional risk factors have also been sought. Many markers, including C-reactive protein and interleukins, highlight inflammation as a key mediator in both the progression and activation of atherosclerotic lesions.2-4 Some medications that are used to prevent cardiovascular diseases, such as statins, also appear to reduce inflammation. 5 Animal experiments have shown that pneumococcal vaccination reduces the extent of atherosclerotic lesions. 6 We hypothesized that antibodies directed against Streptococcus pneumoniae also recognize oxidized low-density lipoprotein (LDL) and impede the formation of foam cells. Interestingly, a retrospective cohort study involving World War II veterans who had undergone splenectomy documented excess mortality rates from both pneumonia and ischemic heart disease. 7 More recent data have suggested that acute pneumococcal infections, but not vaccinations, increase the risk of vascular events; 8 however, the duration of vaccination exposure considered in that study was limited.Our primary objective was to evaluate the association between pneumococcal vaccination and the risk of myocardial infarction. We also explored whether any effect of vaccination on the risk of infarction waned over time.
Methods
Design and ethics approvalWe conducted a case-control study of patients who were considered at risk for myocardial infarction and who had been admitted to a tertiary care hospital. We obtained approval for this study from the research ethics board of the Centre hospitalier universitaire de Sherbrooke and Quebec's Commission d'accès à l'information.
Data sourcesWe used 2 databases for this study. The first was the research-purpose database 9 of the Centre informatisé de recherche évaluative en services et soins de santé of the Centre hospitalier universitaire de Sherbrooke, a tertiary care teaching hospital in the province of Quebec. Along with demographic data, this database included, for each hospital admission since 1996, detailed information on all primary and secondary diagnoses, coded according to the International Classification of Diseases, 9th revision (ICD-9). This database also contained all biochemical and pharmaceutical data recorded during the admission, including, for each medication prescribed, the name, dosage, formulation, quantity dis-
Pneumococcal vaccination and risk of myocardial infarctionFrom the Department of Medicine (Lamontagne, Garant, Carvalho, Lanthier, Pilon), Université de Sherbrooke, Sherbrooke, Que.; and the Department of Clinical Epidemiology and Biostatistics (Lamontagne, Smieja), McMaster University, Hamilton, Ont.
CMAJ
ResearchBackground: Based on promising results from laboratory studies, we hypothesized that pneumococcal vaccination would protect patients from myocardial infarction.
Methods:We conducted a hospital-based ...