Integrating <i>in situ</i> formation of nanozymes with mesoporous polydopamine for combined chemo, photothermal and hypoxia-overcoming photodynamic therapy

Hu, Xiaochun; Lu, Yonglin; Shi, Xiaoke; Yao, Tianming; Dong, Chunyan; Shi, Shuo

doi:10.1039/c9cc07125c

Cited by 47 publications

(29 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A nanoplatform based on mesoporous polydopamine (MPDA) modified with Pt also produces O 2 by decomposing overexpressed H 2 O 2 in the tumor. Meanwhile, the existence of Pt can act as a nano-factory to provide support for PDT ( Figure 9 ) [ 140 ]. (ii) Taking advantage of the deficiency of oxygen molecules is a new approach for drug release and PDT.…”

Section: Microenvironment-targeted Nano-delivery System As a Promising Strategymentioning

confidence: 99%

“… ( A ) Schematic illustration of the synthesis of MPDA-Pt-BSA/ Ce6/DOX (M-Pt-BCD); ( B ) schematic illustration of the application of M-Pt-BCD for enhanced- PDT and synergistic therapy; ( C ) O 2 generation of H 2 O 2 blank, M-BCD and M-Pt-BCD; ( D ) 1 O 2 production efficiency of H 2 O, H 2 O 2 , M-BCD and M-Pt-BCD; ( E ) confocal microscopic images of cellular 1 O 2 levels detected by DCFH-DA staining upon 650 nm irradiation; ( F ) tumor growth curves, reproduced by permission of The Royal Society of Chemistry [ 140 ]. …”

Section: Figurementioning

confidence: 99%

See 1 more Smart Citation

Exploiting a New Approach to Destroy the Barrier of Tumor Microenvironment: Nano-Architecture Delivery Systems

Sun

Shi

et al. 2021

Molecules

Self Cite

View full text Add to dashboard Cite

Recent findings suggest that tumor microenvironment (TME) plays an important regulatory role in the occurrence, proliferation, and metastasis of tumors. Different from normal tissue, the condition around tumor significantly altered, including immune infiltration, compact extracellular matrix, new vasculatures, abundant enzyme, acidic pH value, and hypoxia. Increasingly, researchers focused on targeting TME to prevent tumor development and metastasis. With the development of nanotechnology and the deep research on the tumor environment, stimulation-responsive intelligent nanostructures designed based on TME have attracted much attention in the anti-tumor drug delivery system. TME-targeted nano therapeutics can regulate the distribution of drugs in the body, specifically increase the concentration of drugs in the tumor site, so as to enhance the efficacy and reduce adverse reactions, can utilize particular conditions of TME to improve the effect of tumor therapy. This paper summarizes the major components and characteristics of TME, discusses the principles and strategies of relevant nano-architectures targeting TME for the treatment and diagnosis systematically.

show abstract

Section: Microenvironment-targeted Nano-delivery System As a Promising Strategymentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Exploiting a New Approach to Destroy the Barrier of Tumor Microenvironment: Nano-Architecture Delivery Systems

Sun

Shi

et al. 2021

Molecules

Self Cite

View full text Add to dashboard Cite

show abstract

“…In another similar work, Hu and coworkers demonstrated a multi‐functional nanoplatform based on MPDA‐loaded Pt/Ce6/DOX for PDT/PTT/chemotherapy. [ 181 ] This obtained MPDA‐Pt‐Ce6‐DOX revealed a high loading capacity of Ce6 (36.1%) and DOX (18.2%), and high photothermal conversion efficiency (≈23%). The generated O 2 could be converted into 1 O 2 under 650 nm irradiation and enhanced the PDT effect.…”

Section: Pda Nanostructures With High Surface Areas Toward Adhesion‐driven Bioapplicationsmentioning

confidence: 98%

Intervention of Polydopamine Assembly and Adhesion on Nanoscale Interfaces: State‐of‐the‐Art Designs and Biomedical Applications

Xie

Tang

Xing

et al. 2021

Adv Healthcare Materials

View full text Add to dashboard Cite

The translation of mussel‐inspired wet adhesion to biomedical engineering fields have catalyzed the emergence of polydopamine (PDA)‐based nanomaterials with privileged features and properties of conducting multiple interfacial interactions. Recent concerns and progress on the understanding of PDA's hierarchical structure and progressive assembly are inspiring approaches toward novel nanostructures with property and function advantages over simple nanoparticle architectures. Major breakthroughs in this field demonstrated the essential role of π–π stacking and π‐cation interactions in the rational intervention of PDA self‐assembly. In this review, the recently emerging concepts in the preparation and application of PDA nanomaterials, including 3D mesostructures, low‐dimensional nanostructures, micelle/nanoemulsion based nanoclusters, as well as other multicomponent nanohybrids by the segregation and organization of PDA building blocks on nanoscale interfaces are outlined. The contribution of π‐electron interactions on the interfacial loading/release of π electron‐rich molecules (nucleic acids, drugs, photosensitizers) and the exogenous coupling of optical energy, as well as the impact of wet‐adhesion interactions on the nano‐bio interface interplay, are highlighted by discussing the structure‐property relationships in their featured applications including fluorescent biosensing, gene therapy, drug delivery, phototherapy, combined therapy, etc. The limitations of current explorations, and future research directions are also discussed.

show abstract

“…Light-and temperature-responsiveness bring photodynamic therapy (PDT), photothermal therapy (PTT) into the field of vision [37,69,70,75]. Several multifunctional nanoplatforms which demonstrated a combined PDT, PTT, and chemotherapy for cancer treatment were established in our laboratory [76,77]. Taking the versatile nanoplatform based on a zirconium framework (named UiO-Ra-DOX-CuS) as an example, it was synthesized by following the process: a Ru II polypyridyl alkyne complex (Ra) as a photosensitizer was modified into metal-organic frameworks (MOFs) by the click reaction, and DOX was incorporated into porous of MOFs to play the role of chemotherapeutic agent, and small CuS NPs as the PTT agent was loaded on the surface of the nanoplatform by physical absorption [77].…”

Section: Tumor Chemotherapymentioning

confidence: 99%

Nanotechnologies for enhancing cancer immunotherapy

et al. 2020

Self Cite

View full text Add to dashboard Cite

Immunotherapy, a burgeoning field differs from traditional cancer treatments, is revolutionizing oncologic therapeutics. It aims to stimulate the innate and adaptive immune system of a patient to fight against tumor cells. However, low response rate and immune-related adverse effects (irAEs) remain problems during its management. A novel technology using nanomaterials may bring a solution. Various nanoparticles have been investigated as delivery systems to augment cancer therapeutic efficacy in the lab and clinic. In this review, we briefly summarize the connotation of immunotherapy, the application of nanotechnology in cancer, especially focusing on the synergistic effect of nanoplatform-based technology combined with cancer immunotherapy, hoping to make readers a deep insight into this interdisciplinary field.

show abstract

Integrating in situ formation of nanozymes with mesoporous polydopamine for combined chemo, photothermal and hypoxia-overcoming photodynamic therapy

Abstract: A multi-functional nanoplatform (M-Pt-BCD) for combined chemo, photothermal and hypoxia-overcoming photodynamic therapy is described.

Cited by 47 publications

References 22 publications

Exploiting a New Approach to Destroy the Barrier of Tumor Microenvironment: Nano-Architecture Delivery Systems

Exploiting a New Approach to Destroy the Barrier of Tumor Microenvironment: Nano-Architecture Delivery Systems

Intervention of Polydopamine Assembly and Adhesion on Nanoscale Interfaces: State‐of‐the‐Art Designs and Biomedical Applications

Nanotechnologies for enhancing cancer immunotherapy

Contact Info

Product

Resources

About