Rivers are subject to increasing human pressure, resulting in a loss of their natural characteristics, further enhanced by climate change. The present study focuses on a piedmont reach of the Italian Po River and combines Landsat satellite information with hydrological records to investigate changes in sandbars exposure and riparian vegetation coverage, considering the summer period of 1984–2022. Satellite data were handled via Google Earth Engine, looking at common indexes such as the Modified Normalized Difference Water Index, which was used to identify temporal variations in wetted channel area, and the Normalized Difference Vegetation Index, considered as a proxy of vegetation coverage variations. Changes in the river hydrology were analysed by looking at the annual minimum water levels, the discharge duration curve, the stage–discharge relationship and the yearly annual water volume. Results suggest that a process of oversimplification is affecting this reach of the Po River, showing how climate change can affect piedmont European watercourses. Indeed, after an initial period where bars tended to be barer and somehow stable over time, in the most recent decade a different trend appeared, with vegetation able to colonize the exposed sandbars more. Using the Po River as an exemplary case study, this work suggests that prolonged dry periods, which are more common in recent decades, might impact large and medium rivers located in temperate climates, favouring the development of vegetation on exposed sandbars, eventually resulting in a less dynamic active channel.