Integrating Ordered Two-Dimensional Covalent Organic Frameworks to Solid-State Nanofluidic Channels for Ultrafast and Sensitive Detection of Mercury

Abstract

Grafting specific recognition moieties onto solid-state nanofluidic channels is a promising way for selective and sensitive sensing of analytes. However, the time-consuming interaction between recognition moieties and analytes is the main hindrance to the application of nanofluidic channel-based sensors in rapid detection. Here, we show the integration of ordered twodimensional covalent organic frameworks (2D COFs) to solid-state nanofluidic channels to achieve rapid, selective, and sensitive detection of contaminants. As a proof of concept, a thiourea-linked 2D COF (JNU-3) as the recognition unit is covalently bonded on the stable artificial anodic aluminum oxide nanochannels

Solid-state nanochannels for bio-marker analysis

“…Using the specific affinity between the mercury ion (Hg 2+ ) and the thiourea group in covalent organic framework (COF) film, Yan's group developed an irreversible 2D thiourea-linked COF film on the surface of solid-state nanochannels, and achieved ultra-fast (90s) and ultra-sensitive (3.28 fg mL −1 ) detection of Hg 2+ . 71 By modifying the chloramphenicol (CAP) aptamer and CAP aptamer linker on the outer surface of the nanochannels, a nanochannel-based sensor was prepared. When the sensor was combined with CAP, the CAP aptamer linker fell off (Fig.…”

Nanoporous anodic alumina-based iontronics: fundamentals and applications

“…176 Other structural and chemical modification strategies of through-hole NAA membranes have been reported for the detection of drug molecules, 177 proteins, 38,178,179 small molecules, 180 and heavy metal ions. 181,182 All these systems are characterized by harnessing ionic current changes associated with changes in surface charge and ion migration pathway upon chemical interactions.…”

Enzyme Regulating the Wettability of the Outer Surface of Nanochannels

“…In previous works, our group has proposed the concept of using the outer surface of nanochannels for detection. − By distinguishing the inner wall from outer surface and precisely modifying the functional probes on the outer surface (P OS ), the possibility for biotarget recognition could be largely improved, and the limitation of target size can also be overcome. It has been proven that the surface charge variation of outer surface could be employed to detect various biotargets. − However, the characteristics of solid surface charge might be affected by the ion concentration, detection environment, and even instrument. Compared to the surface charge, wettability relies on the inherent physical property of materials and is less affected by external factors.…”