Integrating sol–gel with cold plasmas modified porous polycaprolactone membranes for the drug-release of silver-sulfadiazine and ketoprofen

Mangindaan, Dave; Chen, Chao-Ting; Wang, Meng-Jiy

doi:10.1016/j.apsusc.2012.03.003

Cited by 28 publications

(21 citation statements)

References 37 publications

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“…The PCL membranes were prepared by the phase inversion method described by Mangindaan et al Briefly, a mixture of PCL pellets and PEG with molecular weight of 400 and 1500 kDa was co‐dissolved in NMP to prepare a homogeneous solution which was casted onto glass substrate using a film applicator (Elcometer®, UK), in a predetermined thickness of 200 μm. The glass plate was then immediately immersed in a coagulation bath containing 60% deionized water and 40% acetone for 10 min.…”

Section: Methodsmentioning

confidence: 99%

“…In each sampling, the drawn volume of 2‐ml PECF was replaced with fresh release medium of the same volume to satisfy the sink conditions. The drug loading efficiency (DE) and the corrected drug concentrations were calculated by eqns and (4):

DE = \frac{encapsulated drug}{maximum encapsulation}

…”

Section: Methodsmentioning

confidence: 99%

“…The mean pore size of the modified PCL membrane was about 6.20 ± 1.40 μm which affects cell proliferation . Focusing on the pore size requirement, the optimal pore diameter for proliferation of human dermal fibroblast was shown to be greater than 6 μm by Lowery et al For an effective design of a functional wound dressing, occasionally, drug‐loaded wound dressings are used to locally release drugs such as antibiotics due to secondary infection or sedatives for pain control, especially in chronic wounds . Lidocaine hydrochloride (HCl) is the most commonly used local anaesthetic having an amine group bonded to an aromatic ring and blocking peripheral nerves in administration sites …”

Section: Introductionmentioning

confidence: 99%

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Preparation of chitosan–silica/PCL composite membrane as wound dressing with enhanced cell attachment

Kiadeh

Ghaee

Mashak

et al. 2017

Polymers for Advanced Techs

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In the present study, the asymmetrical polycaprolactone membranes were synthesized using phase inversion method and modified by addition of Pluronic (F‐127) and sodium hydroxide treatment to improve the cell attachment. The chemical structure, physical properties and mechanical behavior of the membranes as well as cell attachment and proliferation on them were characterized and compared to determine the appropriate membrane used in wound dressing fabrication. Then, a composite membrane as wound dressing capable of drug controlled‐release was prepared composed of two merged layers: an asymmetrical poly(ε‐caprolactone) layer coated with a drug‐loaded chitosan–silica matrix. Drug release behavior and biocompatibility of the final system were evaluated. The results showed that the polycaprolactone modified membrane provides appropriate properties to expand fibroblast cell adhesion and proliferation. This in‐vitro study also showed that the controlled‐release composite wound dressing was developed with approximately 70% cumulative release rate, which provided a porous substrate to support skin cells. Copyright © 2017 John Wiley & Sons, Ltd.

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Section: Methodsmentioning

confidence: 99%

DE = \frac{encapsulated drug}{maximum encapsulation}

…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Preparation of chitosan–silica/PCL composite membrane as wound dressing with enhanced cell attachment

Kiadeh

Ghaee

Mashak

et al. 2017

Polymers for Advanced Techs

View full text Add to dashboard Cite

show abstract

“…[10][11][12][13][14] Moreover, biocompatible polymer wound dressing materials (semipermeable lms, foams, hydrogels, hydrocolloids and xerogels) are intensively investigated in order to accelerate wound healing by preventing both uid loss and bacterial infection by controlled antibacterial release. [15][16][17][18][19][20] In recent years, nanoporous silica-based drug delivery systems have also been developed. 21,22 Nanoporous silica carriers (SBA-15 or MCM-41) are biocompatible materials, and they have the capability to load nanosized metal particles into the channels and can be functionalized with organic groups.…”

Section: Nanosuspensionsmentioning

confidence: 99%

Silver- and sulfadiazine-loaded nanostructured silica materials as potential replacement of silver sulfadiazine

et al. 2014

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Silver sulfadiazine (AgSD) is the leading topical antibacterial agent for the treatment of burn wound infections. Antibacterial effect of AgSD is limited by its poor aqueous solubility, and antibacterial activity develops only by decomposition of AgSD to silver ions and sulfadiazine. In this study, it is for the first time that application of silver-modified nanoporous silica carriers (MCM-41 or SBA-15) loaded with sulfadiazine (SD), instead of silver sulfadiazine, overcoming the abovementioned disadvantages has been demonstrated. By direct or post synthesis methods, 5-15 nm sized silver nanoparticles can be stabilized in the channels or on the outer surface of nanoporous silica supports; moreover, the empty channels can be loaded by SD molecules. The SD-loaded, silver-modified materials show sustained release properties and similar or even better antimicrobial properties than AgSD. Adsorption of AgSD on nanoporous silica particles significantly improves its water solubility.

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“…Sutures exist to help the body heal after injury, and are a good candidate for localized drug delivery because, like many local delivery vehicles, they already exist at the injury site (Table 6). [51][52][53][54][55][56][57][58][59] The reduction of inflammation at the site of injury is dually advantageous. NSAIDs can help to suppress both pain and infection, which helps with patient quality of life and wound healing.…”

Section: Wound Dressings and Suturesmentioning

confidence: 99%

Localized and targeted delivery of NSAIDs for treatment of inflammation: A review

Haley

Recum

2018

Exp Biol Med (Maywood)

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Inflammatory processes are increasingly being identified at the core of many different disease states (e.g. heart disease, cancer, diabetes). As such, anti-inflammatory strategies available through drug delivery have undergone renewed interest. Due to the systemic side effects of steroidal drugs, non-steroidal anti-inflammatory drugs are often preferred for long-term treatment of inflammation in a variety of applications. While non-steroidal anti-inflammatory drugs are generally safe, there are some serious side effects that can be associated with their usage, particularly when given systemically or orally. Due to the high number of patients taking non-steroidal anti-inflammatory drugs, the reduction or elimination of these side effects, such as is possible through local drug delivery, could have a very powerful effect on patient quality of life. This review comments on a sampling of existing methods for localized or targeted delivery of non-steroidal anti-inflammatory drugs, with the goal of helping future research groups to focus on bettering methods shown to be effective and filling the gaps of knowledge in this field. Additionally, commentary is made on the field as a whole, and the standardization issues that arise from its expansiveness and diversity. Impact statement This work provides an overview of research currently being done exploring potential drug delivery device strategies for NSAIDs as an alternative to systemic delivery. Commentary on this field is made in an attempt to aid future experimental design, enabling researchers to determine the drugs and delivery vehicles which are most advantageous for them to pursue, as well as suggestions to standardize the reporting of such future research.

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Integrating sol–gel with cold plasmas modified porous polycaprolactone membranes for the drug-release of silver-sulfadiazine and ketoprofen

Cited by 28 publications

References 37 publications

Preparation of chitosan–silica/PCL composite membrane as wound dressing with enhanced cell attachment

Preparation of chitosan–silica/PCL composite membrane as wound dressing with enhanced cell attachment

Silver- and sulfadiazine-loaded nanostructured silica materials as potential replacement of silver sulfadiazine

Localized and targeted delivery of NSAIDs for treatment of inflammation: A review

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