Integration of a guided-mode resonance filter with microposts for in-cell protein detection

Tu, Yi-Kai; Tsai, Meng-Zhe; Lee, I‐Chin; Hsu, Hsin-Yun; Huang, C. P.

doi:10.1039/c6an00023a

Cited by 25 publications

(11 citation statements)

References 24 publications

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“…Compared with the electric field distribution with the metal reflector layer shown in Figure 2e, most of the electric field distributes in the substrate layer rather than in the analytes when there is no metal reflector layer. The increase in sensitivity from 15 nm/RIU with H m = 0 nm to 420 nm/RIU with H m = 100 nm could be due to the asymmetrical evanescent diffraction field wave distribution in the waveguide layer and the distribution of more electric field intensity in the analytes [19].…”

Section: Influence Of Hm On Madg Based Gmr Sensor Performancementioning

confidence: 99%

“…GMR refers to the resonance between the incident light modulated by the grating and the conduction mode of the waveguide, and the GMR effect is widely used in the sensing field due to the advantages of simple structure, easy detection schemes, high efficiency, and narrow linewidth [12]. However, GMR sensors typically have relatively low sensitivity (<200 nm/RIU) and a small figure of merit (FOM, <100 1/RIU), which is defined as the sensitivity of the sensor divided by the full width at half maximum (FWHM) of the resonance (Sensitivity/FWHM) [16][17][18][19][20]. Biosensors with large sensitivity and FOM are more desirable since a large signal noise ratio is achievable for accurate detection of small signals during biosensing [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

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High Performance of a Metal Layer-Assisted Guided-Mode Resonance Biosensor Modulated by Double-Grating

Zhang

Zhou

et al. 2021

Biosensors

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Guided-mode resonance (GMR) sensors are widely used as biosensors with the advantages of simple structure, easy detection schemes, high efficiency, and narrow linewidth. However, their applications are limited by their relatively low sensitivity (<200 nm/RIU) and in turn low figure of merit (FOM, <100 1/RIU). Many efforts have been made to enhance the sensitivity or FOM, separately. To enhance the sensitivity and FOM simultaneously for more sensitive sensing, we proposed a metal layer-assisted double-grating (MADG) structure with the evanescent field extending to the sensing region enabled by the metal reflector layer underneath the double-grating. The influence of structural parameters was systematically investigated. Bulk sensitivity of 550.0 nm/RIU and FOM of 1571.4 1/RIU were obtained after numerical optimization. Compared with a single-grating structure, the surface sensitivity of the double-grating structure for protein adsorption increases by a factor of 2.4 times. The as-proposed MADG has a great potential to be a biosensor with high sensitivity and high accuracy.

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Section: Influence Of Hm On Madg Based Gmr Sensor Performancementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

High Performance of a Metal Layer-Assisted Guided-Mode Resonance Biosensor Modulated by Double-Grating

Zhang

Zhou

et al. 2021

Biosensors

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“…Since Magnusson and Wang suggested the application of the GMR effect for sensing purposes due to its narrow, controllable linewidth and high efficiency [5], many researchers have shown great interest in GMR sensors, especially in biosensing [6,7,8,9,10,11,12,13]. To date, there are four main detection schemes for GMR sensors, including wavelength detection [14,15,16,17], angular shift detection [18,19,20], intensity shift detection [21,22,23,24,25], and phase shift detection [26,27,28,29].…”

Section: Introductionmentioning

confidence: 99%

Guided Mode Resonance Sensors with Optimized Figure of Merit

et al. 2019

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The guided mode resonance (GMR) effect is widely used in biosensing due to its advantages of narrow linewidth and high efficiency. However, the optimization of a figure of merit (FOM) has not been considered for most GMR sensors. Aimed at obtaining a higher FOM of GMR sensors, we proposed an effective design method for the optimization of FOM. Combining the analytical model and numerical simulations, the FOM of “grating–waveguide” GMR sensors for the wavelength and angular shift detection schemes were investigated systematically. In contrast with previously reported values, higher FOM values were obtained using this method. For the “waveguide–grating” GMR sensors, a linear relationship between the grating period and groove depth was obtained, which leads to excellent FOM values for both the angular and wavelength resonance. Such higher performance GMR sensors will pave the way to lower detection limits in biosensing.

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“…Resonant gratings offer a simple structure with a minimal number of layers, which have a rich variety of applications such as optical filters [1], [2], photonics detectors [3], sensors [4], and switch devices [5], etc. Among the numerous applications, guided mode resonant filter (GMRF) which incorporates resonant coupling to leaky Bloch modes in the waveguide-grating layer system has drawn much attention recently, because of its high diffraction efficiency, narrow band, spectral or color sensitivity, etc.…”

Section: Introductionmentioning

confidence: 99%

Polarization-Independent Filter Based on 2-D Crossed Grating Under Oblique Incidence

Wang

Zhan

2018

IEEE Photonics J.

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The existing polarization-insensitive filters based on two dimensional (2-D) grating are mostly under normal incidence. However, in filtering optical devices, the normal incidence regime is usually avoided because it requires the use of beam separators which yields a loss of efficiency. Herein, we present a compact method to realize polarizationindependent filter under oblique incidence, which is implemented on 2-D crossed grating in the telecommunication region. Plane of incidence is set to be in xz plane and three different polarization angles (0°, 45°, and 90°) are used to demonstrate the polarization-insensitivity. Realization of the polarization-insensitivity of the 2-D filter is based on the split feature under oblique incidence, according to the analysis of the physical mechanism. The location of the polarization-independent resonance is mainly determined by the grating period along x-axis and will right shift with increasing the period. Results show that the polarization-insensitive resonances occur at 1356.9 nm, 1372.6 nm and 1398.5 nm when the grating periods along x-axis are 830 nm, 850 nm and 870 nm, respectively. Moreover, the results and methods provided herein can be applied to search for the polarization-insensitive resonances of the 2-D grating with other planes of incidence.

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Integration of a guided-mode resonance filter with microposts for in-cell protein detection

Cited by 25 publications

References 24 publications

High Performance of a Metal Layer-Assisted Guided-Mode Resonance Biosensor Modulated by Double-Grating

High Performance of a Metal Layer-Assisted Guided-Mode Resonance Biosensor Modulated by Double-Grating

Guided Mode Resonance Sensors with Optimized Figure of Merit

Polarization-Independent Filter Based on 2-D Crossed Grating Under Oblique Incidence

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