Integration of lysozyme into chitosan nanoparticles for improving antibacterial activity

Wu, Tiantian; Wu, Chunhua; Fu, Shalu; Wang, Liping; Yuan, Chunhong; Chen, Shiguo; Hu, Yaqin

doi:10.1016/j.carbpol.2016.08.076

Cited by 143 publications

(87 citation statements)

References 45 publications

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“…The turbidometric and micro‐dilution methods were applied to examine MIC . 0.5 mL different concentrations of each sample were added to 5 mL of liquid medium.…”

Section: Methodsmentioning

confidence: 99%

Antimicrobial activity of Fe‐loaded chitosan nanoparticles

Qian

Pan

Liang

2017

Engineering in Life Sciences

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To increase the antimicrobial activities of chitosan, chitosan nanoparticles loaded with Fe 2+ or Fe 3+ were prepared by surfactant-assisted chitosan chelating Fe 2+ , Fe 3+ and ionic gelation chitosan. Their chelating rates were determined by spectrophotometry. The particle sizes and zeta potentials of chitosan nanoparticles loaded with Fe 2+ or Fe 3+ were measured by size and zeta potential analysis. The nanoparticles antimicrobial activities were evaluated by different concentration against Escherichia coli, Staphylococcus aureus, Candida albicans in vitro. Results showed that the mean diameter of chitosan nanoparticles loaded with Fe 2+ or Fe 3+ were 206.4 and 195.2 nm, respectively. Their zeta potentials were +28.82 and +28.26 mV, respectively. The chelating rate of chitosan nanoparticles loaded with Fe 2+ was greatly higher than with Fe 3+ . Their antimicrobial activity was showed greatly higher at lower concentrations compared to chitosan, and the antibacterial effect of chitosan nanoparticles loaded with Fe 2+ or Fe 3+ was preliminary observed.

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“…The turbidometric and micro‐dilution methods were applied to examine MIC . 0.5 mL different concentrations of each sample were added to 5 mL of liquid medium.…”

Section: Methodsmentioning

confidence: 99%

Antimicrobial activity of Fe‐loaded chitosan nanoparticles

Qian

Pan

Liang

2017

Engineering in Life Sciences

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“…Chitosan can be prepared from deacetylation of chitin, which is found in the shells of crustaceans, as a waste product of seafood industries . Different than cellulose, chitosan can be hydrolyzed by lysozyme, thus being biodegradable . Moreover, chitosan is biocompatible and also possesses hemostatic, antibacterial, and mucoadhesive properties, thus potentially offering a broad spectrum of applications in tissue engineering and drug delivery.…”

Section: Technologies and Materials For Tailor‐made Drug Delivery/diamentioning

confidence: 99%

Tailored Approaches in Drug Development and Diagnostics: From Molecular Design to Biological Model Systems

Sahlgren

Meinander

Zhang

et al. 2017

Adv Healthcare Materials

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Approaches to increase the efficiency in developing drugs and diagnostics tools, including new drug delivery and diagnostic technologies, are needed for improved diagnosis and treatment of major diseases and health problems such as cancer, inflammatory diseases, chronic wounds, and antibiotic resistance. Development within several areas of research ranging from computational sciences, material sciences, bioengineering to biomedical sciences and bioimaging is needed to realize innovative drug development and diagnostic (DDD) approaches. Here, an overview of recent progresses within key areas that can provide customizable solutions to improve processes and the approaches taken within DDD is provided. Due to the broadness of the area, unfortunately all relevant aspects such as pharmacokinetics of bioactive molecules and delivery systems cannot be covered. Tailored approaches within (i) bioinformatics and computer‐aided drug design, (ii) nanotechnology, (iii) novel materials and technologies for drug delivery and diagnostic systems, and (iv) disease models to predict safety and efficacy of medicines under development are focused on. Current developments and challenges ahead are discussed. The broad scope reflects the multidisciplinary nature of the field of DDD and aims to highlight the convergence of biological, pharmaceutical, and medical disciplines needed to meet the societal challenges of the 21st century.

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“…Many studies have mainly focused on the antibacterial effect of food preservatives during food storage [22,23] , whereas studies of the antibacterial effect for specific bacteria are comparatively less. Thus, this study aims to investigate whether the antioxidant activity of FA in the aqueous phase could be maintained in FA-β-cyclodextrin inclusion complexes (FCICs) and examine the antibacterial activity of FCIC against bacteria in hairtail.…”

Section: Introductionmentioning

confidence: 99%

Ferulic acid-β-cyclodextrin inclusion complexes: Application on the preservation of hairtail (Trichiurus lepturus)

Cai

et al. 2020

International Journal of Food Properties

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A new method to stabilize ferulic acid (FA) in the aqueous phase by encapsulating FA into β-cyclodextrin was developed to prepare ferulic acid-βcyclodextrin inclusion complexes (FCICs), and the potential applications of FCIC as a preservative in hairtail (Trichiurus lepturus) were tested. The antibacterial properties of specific spoilage bacteria in hairtail were analyzed. FCIC possessed significantly higher efficacy (p < .05) of scavenging DPPH and H 2 O 2 radicals. In the antibacterial assessment, several strains isolated from hairtail after ten days of storage were selected. FCIC showed significantly higher antibacterial activities (p < .05) against these bacteria. To further validate whether the antioxidant and antibacterial activities of hairtail remained throughout storage, the physiological properties of hairtail were analyzed. It was shown that hairtailtreatment with FCIC inhibited the spoilage of hairtail throughout storage at 4°C. FCIC with an FA:β-CD ratio of 1:2 (IC1:2) could prolong the shelf life of refrigerated hairtail for 3-5 days. This study provided an enormous potential for applying FA in the shelf-life extension of hairtail.

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Integration of lysozyme into chitosan nanoparticles for improving antibacterial activity

Cited by 143 publications

References 45 publications

Antimicrobial activity of Fe‐loaded chitosan nanoparticles

Antimicrobial activity of Fe‐loaded chitosan nanoparticles

Tailored Approaches in Drug Development and Diagnostics: From Molecular Design to Biological Model Systems

Ferulic acid-β-cyclodextrin inclusion complexes: Application on the preservation of hairtail (Trichiurus lepturus)

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