Integration of Manganese Dioxide‐Based Nanomaterials for Biomedical Applications

Abstract

Advancements in nanotechnology have promoted the rapid development of diverse nanosystems for biomedical applications. Manganese dioxide (MnO2) nanomaterials have attracted numerous attentions in the field of biosensing and cancer treatment due to their unique properties, such as simple fabrication procedures, broad optical absorption, and high oxidation and catalytic ability. Especially, the intelligent stimuli‐responsiveness of MnO2 nanomaterials to tumor microenvironment (TME) greatly improves their performance in tumor imaging and cancer therapy. In this review, the synthetic methods of different MnO2 nanostructures (nanoparticles, nanosheets, and nanoflowers) are first introduced, followed by the introduction of MnO2 nanomaterials for various biosensing applications based on their unique characteristics. Then, the recent achievements and progress of MnO2 nanomaterials for cancer treatment are comprehensively summarized with a focus on various therapeutic enhancements profiting from their disassembled ingredients under TME guidance. Finally, the current challenges and future perspectives of this promising research are discussed in the fields of biomedicine.

Tumor targeted nanohybrid for dual stimuli responsive and NIR amplified photothermal/photo-induced thermodynamic/chemodynamic combination therapy

“…BSA nanoparticles were chosen as the base for the nanoplatform due to their excellent biocompatibility and biodegradability as well as their naturally high affinity for binding both hydrophilic and hydrophobic molecules [27]. BSA solutions have also often been used for simultaneous reduction and stabilization in the synthesis of MnO 2 nanoparticles and nanodots [28][29][30]. However, not much is known about the use of BSA nanoparticles as biotemplates for preparation of MnO 2 core shell nanoparticles.…”

Manganese Dioxide-Based Nanomaterials for Medical Applications

“…Various MnO 2 -based diagnosis and treatment platforms have been explored for tumor imaging and treatment. 127 The physical and chemical properties of MnO 2 have also been shown to offer great advantages in the treatment of bone-related diseases, cardiovascular diseases and nervous system diseases (Table 3). In vivo and in vitro experiments in different animal models have shown that loaded, modified or doped MnO 2 nanomaterials can significantly increase the efficacy of nanotherapy.…”

“…Functional MnO 2 nanoplatforms have attracted great interest due to their responsiveness to the TME and their ability to scavenge ROS. Various MnO 2 -based diagnosis and treatment platforms have been explored for tumor imaging and treatment . The physical and chemical properties of MnO 2 have also been shown to offer great advantages in the treatment of bone-related diseases, cardiovascular diseases and nervous system diseases (Table ).…”

Prospects for the Use of Metal-Based Nanoparticles as Adjuvants for Local Cancer Immunotherapy

“…MnJ showed good adjuvant effects for all tested antigens, including T cell-dependent and T cell-independent antigens [ 188 ]. However, despite MnO 2 nanomaterials having a great potential in the field of biomedicine, a strict biosafety assessment of MnO 2 -based nanosystems is needed in order to comprehensively determine the potential toxicity of Mn-based nanomaterials [ 189 , 190 , 191 ].…”