Integration of mechanotransduction concepts in bone tissue engineering

Pioletti, Dominique P.

doi:10.1080/10255842.2013.780602

Cited by 16 publications

(12 citation statements)

References 35 publications

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“…As the field has progressed, new studies have focused on determining the mechanisms of physical signal transduction (Liu and Lee, 2014; Mammoto et al, 2012; Pioletti, 2013). One goal of this approach has been to take advantage of chemical means to circumvent the standard bioreactor loading systems to directly stimulate cellular responses (O’Conor et al, 2014).…”

Section: Principles Of Functional Tissue Engineeringmentioning

confidence: 99%

Biomechanics and mechanobiology in functional tissue engineering

Guilak

Butler

Goldstein

et al. 2014

Journal of Biomechanics

198

127

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The field of tissue engineering continues to expand and mature, and several products are now in clinical use, with numerous other preclinical and clinical studies underway. However, specific challenges still remain in the repair or regeneration of tissues that serve a predominantly biomechanical function. Furthermore, it is now clear that mechanobiological interactions between cells and scaffolds can critically influence cell behavior, even in tissues and organs that do not serve an overt biomechanical role. Over the past decade, the field of “functional tissue engineering” has grown as a subfield of tissue engineering to address the challenges and questions on the role of biomechanics and mechanobiology in tissue engineering. Originally posed as a set of principles and guidelines for engineering of load-bearing tissues, functional tissue engineering has grown to encompass several related areas that have proven to have important implications for tissue repair and regeneration. These topics include measurement and modeling of the in vivo biomechanical environment; quantitative analysis of the mechanical properties of native tissues, scaffolds, and repair tissues; development of rationale criteria for the design and assessment of engineered tissues; investigation of the effects biomechanical factors on native and repair tissues, in vivo and in vitro; and development and application of computational models of tissue growth and remodeling. Here we further expand this paradigm and provide examples of the numerous advances in the field over the past decade. Consideration of these principles in the design process will hopefully improve the safety, efficacy, and overall success of engineered tissue replacements.

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Section: Principles Of Functional Tissue Engineeringmentioning

confidence: 99%

Biomechanics and mechanobiology in functional tissue engineering

Guilak

Butler

Goldstein

et al. 2014

Journal of Biomechanics

198

127

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“…Recently, it is proposed that in vivo mechanical loading be used to increase bone formation in the scaffold instead of pre-seeding the scaffold with cells or delivering growth factors [30]. Although no direct comparison of mechanical strength of scaffolds, the TCP scaffold using the present study can't maintain the mechanical property when its porous is over 75%.…”

Section: Discussionmentioning

confidence: 93%

High porous titanium scaffolds showed higher compatibility than lower porous beta-tricalcium phosphate scaffolds for regulating human osteoblast and osteoclast differentiation

Hirota

Hayakawa

Shima

et al. 2015

Materials Science and Engineering: C

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“…Such preclinical studies have being assisted throughout parallel researches such as experimental nano-and micro-scale mechanical measurements, the development of constitutive equations [102][103][104][105] and on physical signal transduction, [106][107][108] enabling advances in engineered tissues that were not possible using standard macroscopic phenomenological methods. [109][110][111] Specifically, the studies on mechanotransduction in stem cells serve as means of controlling cells growth and fate through physical and chemical means in the bioreactor.…”

Section: Requirements For the Regeneration Of The Tissues Affected Bymentioning

confidence: 99%

Cellular modelling in functional tissue engineering: review oriented for pelvic floor dysfunctions

Ferreira

Parente

Mascarenhas

et al. 2015

Proceedings of the Institution of Mechanical Engineers, Part L:

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This paper aims to review the current strategies for pelvic floor dysfunctions (PFDs). PFDs, such as stress urinary incontinence, foecal incontinence and vaginal prolapse affect the quality of life in women, involve high healthcare costs, and pose poor long-term success rates. As the problem progresses the cells in the pelvic tissues are impaired. The rheological relations between PFD and the damage of the tissues is not yet well established, bringing out clinical repair interventions, instead of knowing the root problem. As a consequence, the verification of damage mechanisms in the pelvic structures should be observed at cellular scales to correlate with the macroscopic phenomenological pathologies, namely, the changes in the mechanical properties and on the geometric configuration of the pelvic structures. Cells sense mechanical stimuli and respond biochemically via mechanotransduction mechanisms. Therefore, investigations on the cell dynamics must be performed, considering the physical conditions inside the bioreactors, to shed insight into the active behaviour of the cells during the treatment. These investigations should establish the conditions that push a cell to or keep a cell in a desired state during a regenerative treatment. This paper reviews the use of human adult stem cells to regenerate the defective muscles, ligaments and connective tissues in the pelvic floor, focusing on the role of the computational models as an assistive technology for these emergent tissue engineering treatments. First, the pelvic floor anatomy and physiology is related with the kinematic and mechanical behaviour of those structures at the tissue and cell scales. After, the relevance of the regenerative treatments is discussed and the requirements for their application are summarised. Later, the developments on computational models are exposed and the main guidelines for regeneration of the pelvic cavity tissues are proposed.

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Integration of mechanotransduction concepts in bone tissue engineering

Cited by 16 publications

References 35 publications

Biomechanics and mechanobiology in functional tissue engineering

Biomechanics and mechanobiology in functional tissue engineering

High porous titanium scaffolds showed higher compatibility than lower porous beta-tricalcium phosphate scaffolds for regulating human osteoblast and osteoclast differentiation

Cellular modelling in functional tissue engineering: review oriented for pelvic floor dysfunctions

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