2021
DOI: 10.1101/2021.05.21.445181
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Integration of mouse ovary morphogenesis with developmental dynamics of the oviduct, ovarian ligaments, and rete ovarii

Abstract: The morphogenetic events that occur during fetal development of the mammalian ovary are crucial to the establishment of adult female fertility. While our knowledge of the cellular and molecular aspects of ovary development is increasing, the structural rearrangements that give rise to the cortex and medulla and the relation of other female reproductive tissues to the ovary have not been thoroughly investigated. In this study, we used tissue clearing and lightsheet microscopy to investigate the stepwise morphog… Show more

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Cited by 5 publications
(6 citation statements)
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“…These fluids move from the rete into the efferent ducts and from there into the epididymis and further into the vas deferens. The rete ovarii is the female homolog of the rete testis and is characterized by a set of anastomosed tubules located in the hilus of the ovary that may also extend through the ovarian medulla ( 19 , 20 ). The physiological role of the rete ovarii remains unclear, but it has been proposed to be necessary for the initiation of meiosis and a source of pregranulosa cells during embryogenesis ( 21 , 22 ).…”
Section: Introductionmentioning
confidence: 99%
“…These fluids move from the rete into the efferent ducts and from there into the epididymis and further into the vas deferens. The rete ovarii is the female homolog of the rete testis and is characterized by a set of anastomosed tubules located in the hilus of the ovary that may also extend through the ovarian medulla ( 19 , 20 ). The physiological role of the rete ovarii remains unclear, but it has been proposed to be necessary for the initiation of meiosis and a source of pregranulosa cells during embryogenesis ( 21 , 22 ).…”
Section: Introductionmentioning
confidence: 99%
“…The rete ovarii (RO) is an epithelial structure that develops in close association with the ovary during fetal life and remains in adulthood in mammals (1,2). Despite the significant architecture of this ovarian appendage, and the fact that it is highly conserved in mammals (3)(4)(5), the function of the RO has not yet been determined, and it has disappeared from recent descriptions of female reproductive anatomy.…”
Section: Background and Summarymentioning
confidence: 99%
“…The RO is divided into three regions; the intraovarian rete (IOR), which resides inside the ovary, the extraovarian rete (EOR) located in the periovarian tissue, and the connecting rete (CR), which links the EOR and IOR (6). Using the mouse as a model system we developed tissue-clearing and 3D-imaging methods using lightsheet microscopy (7) that allowed us to observe the RO in unprecedented detail (2). The bipotential rete structure first appears in both sexes as a PAX8+ population of cells at the interface between the dorsal aspect of the gonad and the mesonephros (8,9).…”
Section: Background and Summarymentioning
confidence: 99%
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“…A study based on scRNA-seq showed that a new uncharacterized somatic cell population, supporting-like cells (SLCs), contributes to the formation of rete testis and rete ovarii [ 58 ]. Rete testis is an anastomosing canal connecting the seminiferous tubules and the epididymis [ 59 ]; rete ovarii is a group of anastomosing tubules located in the hilum of the ovary [ 60 ]. SLC lineage is the first distinct somatic cell lineage specified in the bipotential gonads, as early as E10.5, before the initiation of gonadal sex determination.…”
Section: Overview Of Early Gonadal Supporting Cell Development In Micementioning
confidence: 99%