Integration of PCL and PLA in a monolithic porous scaffold for interface tissue engineering

Scaffaro, Roberto; Lopresti, Francesco; Botta, Luigi; Rigogliuso, Salvatrice; Ghersi, Giulio

doi:10.1016/j.jmbbm.2016.06.021

Cited by 69 publications

(48 citation statements)

References 42 publications

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“…Several publications have focused on biodegradable polymeric materials. Their goal is to ensure a sustainable industrialization, minimizing the environmental impact of production, and disposal of nonbiodegradable polymeric materials . In fact, the use of biodegradable polymers offers several advantages in environmental conservation due to their nontoxic effects and renewable nature.…”

Section: Introductionmentioning

confidence: 99%

Functionalized cellulose nanocrystals as reinforcement in biodegradable polymer nanocomposites

et al. 2017

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This review describes the use of cellulose nanocrystals (CNC) as fillers in biodegradable polymer matrices over the past few years. The preparation and characterization of CNC‐based nanocomposites are highlighted here with a focus on thermophysical and mechanical properties. The characterization and isolation of nanocellulose from different raw material sources are discussed in detail, as well as different surface modifications. The addition of CNC in biodegradable polymer, combined with nanocellulose surface engineering and driven by sustainability trends, has the potential to impact various industrial sectors. POLYM. COMPOS., 39:E9–E29, 2018. © 2017 Society of Plastics Engineers

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Section: Introductionmentioning

confidence: 99%

Functionalized cellulose nanocrystals as reinforcement in biodegradable polymer nanocomposites

et al. 2017

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“…Melt mixing and particulate leaching have been combined to make PCL, [110] PLA, [111] and PCL/PLA [112] gradient scaffolds. PCL and PLA were mixed at known ratios with PEG and NaCl and compressed, and PEG and NaCl were removed by particulate leaching in water.…”

Section: Solvent Casting and Particulate Leachingmentioning

confidence: 99%

Functionally Graded Biomaterials for Use as Model Systems and Replacement Tissues

Lowen

Leach

2020

Adv Funct Materials

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The heterogeneity of native tissues requires complex materials to provide suitable substitutes for model systems and replacement tissues. Functionally graded materials have the potential to address this challenge by mimicking the gradients in heterogeneous tissues such as porosity, mineralization, and fiber alignment to influence strength, ductility, and cell signaling. Advancements in microfluidics, electrospinning, and 3D printing enable the creation of increasingly complex gradient materials that further the understanding of physiological gradients. The combination of these methods enables rapid prototyping of constructs with high spatial resolution. However, successful translation of these gradients requires both spatial and temporal presentation of cues to model the complexity of native tissues that few materials have demonstrated. This Review highlights recent strategies to engineer functionally graded materials for the modeling and repair of heterogeneous tissues, together with a description of how cells interact with various gradients.

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“…The occurrence of multiphasic structures that gradually vary from one tissue to another is characteristics of interface tissues such as cartilage‐to‐bone junction (Scaffaro, Lopresti, Botta, Rigogliuso, & Ghersi, ). Incipient strategy in tissue engineering to repair an osteochondral defect was focused on fusing separate cartilage and bone forming constructs in a single scaffold.…”

Section: Osteochondral Tissue Regenerationmentioning

confidence: 99%

A review on gradient hydrogel/fiber scaffolds for osteochondral regeneration

Khorshidi

Karkhaneh

2018

J Tissue Eng Regen Med

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Osteochondral tissue regeneration is a complicated field due to the distinct properties and healing potential of osseous and chondral phases. In a natural osteochondral region, the composition, mechanics, and structure vary smoothly from bony to cartilaginous phase. Therefore, a homogeneous scaffold cannot satisfy the complexity of the osteochondral matrix. In essence, a natural extracellular matrix is composed of fibrous proteins elongated into a gelatinous background. A hydrogel/fiber scaffold possessing gradient in both phases would be of the utmost interest to imitate tissue arrangement of a native osteochondral interface. However, there are limited research works that exploit hydrogel/fiber scaffolds for osteochondral restoration. In the present review, currently used fibrous or gelatinous scaffolds for osteochondral damages are discussed. Moreover, superiority of using gradient hydrogel/fiber composites for osteochondral regeneration and practical approaches to develop those scaffolds is debated.

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Integration of PCL and PLA in a monolithic porous scaffold for interface tissue engineering

Cited by 69 publications

References 42 publications

Functionalized cellulose nanocrystals as reinforcement in biodegradable polymer nanocomposites

Functionalized cellulose nanocrystals as reinforcement in biodegradable polymer nanocomposites

Functionally Graded Biomaterials for Use as Model Systems and Replacement Tissues

A review on gradient hydrogel/fiber scaffolds for osteochondral regeneration

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