Integration of phytochemicals and phytotherapy into cancer precision medicine

Efferth, Thomas; Saeed, Mohamed E.M.; Mirghani, Elhaj; Alim, Awadh; Yassin, Zahir; Saeed, Elfatih M.; Khalid, Hassan; Daak, Salah

doi:10.18632/oncotarget.17466

Cited by 89 publications

(38 citation statements)

References 139 publications

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“…Importantly, the use of phytochemicals in cancer therapy is currently becoming highly attractive and advantageous. Therefore, natural plant compounds appear to possess beneficiary effects in the increase of the efficacy and reduction of toxicity associated with PTX [150,151].…”

Section: Novel Insights Into the Application Of Paclitaxel In Clinicamentioning

confidence: 99%

“…As was indicated by the above-mentioned recent studies, PTX delivery mediated through the use of nanocarriers represents great progress in cancer treatment by chemotherapeutic agents. Moreover, improvements in the technologies using the advantages of natural plant compounds to increase the efficacy of PTX indicate potential to maximize therapeutic effects and minimize side effects of PTX in cancer treatment [150,151,153].…”

Section: Novel Insights Into the Application Of Paclitaxel In Clinicamentioning

confidence: 99%

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Paclitaxel’s Mechanistic and Clinical Effects on Breast Cancer

et al. 2019

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Paclitaxel (PTX), the most widely used anticancer drug, is applied for the treatment of various types of malignant diseases. Mechanisms of PTX action represent several ways in which PTX affects cellular processes resulting in programmed cell death. PTX is frequently used as the first-line treatment drug in breast cancer (BC). Unfortunately, the resistance of BC to PTX treatment is a great obstacle in clinical applications and one of the major causes of death associated with treatment failure. Factors contributing to PTX resistance, such as ABC transporters, microRNAs (miRNAs), or mutations in certain genes, along with side effects of PTX including peripheral neuropathy or hypersensitivity associated with the vehicle used to overcome its poor solubility, are responsible for intensive research concerning the use of PTX in preclinical and clinical studies. Novelties such as albumin-bound PTX (nab-PTX) demonstrate a progressive approach leading to higher efficiency and decreased risk of side effects after drug administration. Moreover, PTX nanoparticles for targeted treatment of BC promise a stable and efficient therapeutic intervention. Here, we summarize current research focused on PTX, its evaluations in preclinical research and application clinical practice as well as the perspective of the drug for future implication in BC therapy.

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Section: Novel Insights Into the Application Of Paclitaxel In Clinicamentioning

confidence: 99%

Section: Novel Insights Into the Application Of Paclitaxel In Clinicamentioning

confidence: 99%

Paclitaxel’s Mechanistic and Clinical Effects on Breast Cancer

et al. 2019

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“…Combination therapy of herbal therapy and synthetic drugs possibly be the last resource for patients in the final stage of breast cancer, where surgery is not possible [69]. The combinatory effect of a herbal drug with conventional cancer drugs might improve the bioavailability of one of them making the treatment more effective [69,70]. Additionally, the combinatory use of herbal remedies with chemotherapy will reduce the dose of standard medicine resulting in lower toxicity and side effects [71].…”

Section: Combination Therapy By Herbal Remedies and Synthetic Drugsmentioning

confidence: 99%

Herbal Remedies for Breast Cancer Prevention and Treatment

Laskar¹,

Lourembam²,

Mazumder³

2020

Medicinal Plants - Use in Prevention and Treatment of Diseases

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Breast cancer is among the most common type of cancer in women around the globe. Prevention of breast cancer is better than its treatment. Because of the molecular variation and complexity underlying breast cancer occurrence, its treatment by using chemotherapy and/or radiotherapy is very complicated and often leads to undesirable side effects. Plants and their extracts have been used for centuries for the treatment of almost every disease and breast cancer is not an exception. Herbal products can be trusted for cancer treatment because of their low toxicity. Besides, herbal remedies are easily accepted by the majority of woman suffering from breast cancer because of their easy availability and affordability. In the last decade, a large number of plants and their compounds were reported to show promising anticancerous effects against breast cancer cells in both in vivo and in vitro models. However, their beneficial effects on breast cancer treatment are still doubtful due to the lack of randomized clinical trials. This chapter is dedicated to reporting the potential of some herbal products for the prevention and/or treatment of breast cancer. Besides, it focused on the anticarcinogenic mechanism of those phytocompounds to report their potential chemotherapeutic role.

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“…The “omics” technologies have been utilized to investigate the signaling pathways and biological networks, and identify the pathway mechanisms. However, the large amount of data generated makes it difficult to distinguish between the causative mechanisms . For example, recent deep sequencing of HNSCC genomic landscape reveals a multiplicity and diversity of genetic alterations in malignancy .…”

Section: Nanomaterials For Cancer Precision Therapymentioning

confidence: 99%

Nanomaterials for Cancer Precision Medicine

et al. 2018

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Medical science has recently advanced to the point where diagnosis and therapeutics can be carried out with high precision, even at the molecular level. A new field of "precision medicine" has consequently emerged with specific clinical implications and challenges that can be well-addressed by newly developed nanomaterials. Here, a nanoscience approach to precision medicine is provided, with a focus on cancer therapy, based on a new concept of "molecularly-defined cancers." "Next-generation sequencing" is introduced to identify the oncogene that is responsible for a class of cancers. This new approach is fundamentally different from all conventional cancer therapies that rely on diagnosis of the anatomic origins where the tumors are found. To treat cancers at molecular level, a recently developed "microRNA replacement therapy" is applied, utilizing nanocarriers, in order to regulate the driver oncogene, which is the core of cancer precision therapeutics. Furthermore, the outcome of the nanomediated oncogenic regulation has to be accurately assessed by the genetically characterized, patient-derived xenograft models. Cancer therapy in this fashion is a quintessential example of precision medicine, presenting many challenges to the materials communities with new issues in structural design, surface functionalization, gene/drug storage and delivery, cell targeting, and medical imaging.

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Integration of phytochemicals and phytotherapy into cancer precision medicine

Cited by 89 publications

References 139 publications

Paclitaxel’s Mechanistic and Clinical Effects on Breast Cancer

Paclitaxel’s Mechanistic and Clinical Effects on Breast Cancer

Herbal Remedies for Breast Cancer Prevention and Treatment

Nanomaterials for Cancer Precision Medicine

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