Integration of the Secretory Control Mechanisms for Insulin, Glucagon, and Growth Hormone

Blackard, William G.; Andrews, Samuel S.

doi:10.1016/b978-0-12-153202-4.50011-x

Cited by 6 publications

(3 citation statements)

References 96 publications

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“…The finding of an inhibiting effect of insulin on GH secretion in the duck is in agreement with and extends earlier findings (Scanes & Pethes, 1979). These findings are again quite different from those in mammalian studies, in which insulin is a potent stimulus for GH release in some species, probably by lowering plasma glucose levels (Blackard & Andrews, 1974). Thus it would appear that the inhibitory effects of insulin and glucagon on GH secretion in the duck are not mediated by changes in blood glucose level but are due to direct effects of the pancreatic hormones themselves and in this respect the mutual control of insulin, glucagon and GH secretion in this species differs from that in mammals (Blackard &…”

Section: Discussioncontrasting

confidence: 92%

“…The results of the present study clearly show that in the duck this age-related pattern of GH secretion is not, however, due to or accompanied by maturational changes in insulin or glucagon secretion. Age-related changes in pancreatic function might have been expected in view of the fact that pituitary GH is intimately involved in the control of pancreatic function in ducks (Foltzer et al 1975;Foltzer & Mialhe, 1976) and because some of the factors influencing the secretion of insulin, glucagon and GH in mammals are similar (Blackard & Andrews, 1974;Sirek, Vranic, Sirek, Vigas & Policova, 1979). This is the first time that agerelated changes in pancreatic hormone secretion have been determined in birds and the first time that the influence of glucagon on GH secretion has been assessed in this species.…”

Section: Discussionmentioning

confidence: 99%

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Influence of Insulin and Glucagon on Secretion of Growth Hormone in Growing Ducks (Anas Platyrhynchos)

Foltzer¹,

Harvey²,

Strosser³

et al. 1981

Journal of Endocrinology

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An inverse age-related pattern of GH secretion has been identified in immature ducks between 2 and 9 weeks of age, the plasma level of GH falling progressively from 30-40 ng/ml at 2 weeks of age to the adult level (less than 10 ng/ml) by 9 weeks of age. This decrease in GH secretion was not accompanied by any age-related changes in the concentrations of plasma immunoreactive insulin of glucagon-like immunoreactivity or in plasma glucose or free fatty acid level. In 4- to 6-week-old ducklings the intravenous infusion of insulin (2.5 or 10 mu./kg per min for 30 min) and glucagon (0.1 or 0.5 micrograms/kg per min for 30 min) induced some inhibition of GH secretion, independently of changes in blood glucose level. These results suggest that although insulin and especially glucagon have direct effects on GH secretion in the duck, maturational differences in pancreatic function are unlikely to be causally related to the decrease in GH secretion during growth.

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Section: Discussioncontrasting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Influence of Insulin and Glucagon on Secretion of Growth Hormone in Growing Ducks (Anas Platyrhynchos)

Foltzer¹,

Harvey²,

Strosser³

et al. 1981

Journal of Endocrinology

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“…Increase of plasma amino acid concentration by protein digestion and resorption is generally accepted as the main insulinogenic stimulus after feeding (Blackard and Andrews, 1974; Floyd et al, 1 9 6 7 ) . But this seems to be not the only stimulus for insulin secretion in such situation.…”

mentioning

confidence: 99%

The Effect of Meal Feeding and of Sham‐Feeding on Insulin Secretion in Dogs

Fischer

Hommel

Gottschling

et al. 1976

Eur J Clin Investigation

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After feeding intact conscious dogs 1000 g mashed meat, peripheral venous immunoreactive insulin activity (IRI) increases before any enhancement of amino nitrogen concentration. This course of IRI is paralleled by a decrease of free fatty acids. Meal feeding in dogs, whose pancreatic juice is completely diverted from the gut by a fistula, is followed by a similar IRI increase without a distinct enhancement of amino nitrogen. In oesophagus fistula dogs, sham-feeding meat in 9 out of 15 experiments results in a considerable early IRI increase which is correlated with a small but a significant decrease of blood glucose and free fatty acid concentrations. In these tests there was no amino nitrogen alteration either.

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