Integrative analysis of the role of CCT3 in human pan-cancer

Abstract

Increasing evidence revealed that the carcinogenic effects of chaperonin containing CCT3 in multiple tumors, but there is no pan-cancer analysis of CCT3. In this study, we utilized a series of bioinformatics tools to systematically reveal the expression status, prognostic value, methylation level, immune infiltration relevance and functional mechanisms of CCT3 in thirty-three TCGA tumors in an attempt to provide an in-depth and comprehensive view of the role of CCT3 in malignancies. We found that the dysregulation of CCT3 was manifested at multiple levels, such as transcriptome, protein and promoter region methylation status. In general, the upregulation of CCT3 has been widely observed in most tumor tissues compared with normal tissues, which was closely related to the clinical features of patients. We also discovered that the high CCT3 expression indicated poor overall OS and RFS in ACC, CESC and KIRP. CCT3 was significantly correlated with immune infiltrating cells and immune checkpoints in pan-cancer. Several cancer-related pathways and a novel CCT3-related ceRNA network were eventually identified, providing insights for future studies. In summary, the pan-cancer analysis confirmed that CCT3 could be a promising biological target for assessing the prognosis and immunotherapy of cancers.

The role of CCT5 in human tumors: a pan-cancer analysis

“…Information from pan-cancer analysis can be leveraged to develop targeted therapies and improve cancer diagnosis and treatment strategies 17 . Notably, previous pan-cancer analyses have been conducted for other CCT subunits, namely, CCT2, CCT3, and CCT8 [18][19][20] . However, a comprehensive pan-cancer analysis speci cally focusing on CCT5 is currently lacking, although recent studies have suggested a strong link between the entire CCT gene family and tumor proliferation 3,21 .…”