Human resource development (HRD) academics and practitioners often speak of developing expertise in individuals and unleashing expertise in organizations. For individuals, expertise has professional and personal implications related to employment, work performance, career development, career transition, and resulting livelihood across the life span. For organizations, expertise has implications for training and development; for organizational development, as a competitive advantage; and for performance. Expertise presents challenges and opportunities for HRD and merits additional research to meet such challenges and leverage opportunities to benefit individuals, teams, organization, communities, nations, and humanity. The purpose of this integrative literature review was to examine the construct of expertise within the context of HRD. Findings included where, when, and how authors used expertise in the HRD literature. Major themes comprised expertise and assessment, workforce development, professional development, leadership development, redevelopment, and elicitation and transfer. Findings have implications for theory and practice and inform future research.