2016
DOI: 10.7554/elife.11031
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Integrative neuromechanics of crawling in D. melanogaster larvae

Abstract: Locomotion in an organism is a consequence of the coupled interaction between brain, body and environment. Motivated by qualitative observations and quantitative perturbations of crawling in Drosophila melanogaster larvae, we construct a minimal integrative mathematical model for its locomotion. Our model couples the excitation-inhibition circuits in the nervous system to force production in the muscles and body movement in a frictional environment, thence linking neural dynamics to body mechanics via sensory … Show more

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Cited by 32 publications
(102 citation statements)
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“…At a population level, we observe a deterministic 655 anomalous diffusion process in which an initial superdiffusive transient evolves towards 656 asymptotic Fickian/Brownian diffusion, matching observations of real larvae [6,45]. We 657 therefore propose that the role of biomechanical feedback in Drosophila larvae goes 658 beyond the periphery of basic neuromuscular rhythms [39,40], to provide the essential 659 "higher order" dynamics on which exploratory behaviour is grounded.…”
supporting
confidence: 54%
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“…At a population level, we observe a deterministic 655 anomalous diffusion process in which an initial superdiffusive transient evolves towards 656 asymptotic Fickian/Brownian diffusion, matching observations of real larvae [6,45]. We 657 therefore propose that the role of biomechanical feedback in Drosophila larvae goes 658 beyond the periphery of basic neuromuscular rhythms [39,40], to provide the essential 659 "higher order" dynamics on which exploratory behaviour is grounded.…”
supporting
confidence: 54%
“…The work presented here also stands in contrast to previous models of larval 673 peristalsis [38,40] and the prevailing hypotheses regarding this phenomenon [15,58] by 674 eschewing any role for intrinsic neural dynamics. Such stereotyped and rhythmic 675 locomotion is widely assumed to be the signature of a central pattern generator (CPG), 676 that is, a neural circuit that intrinsically generates a rhythmic output, and thus 677 determines a particular mechanical trajectory to be followed by the body [59][60][61].…”
mentioning
confidence: 58%
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