Integrative pharmacology powers the detection of active components and mechanism underlying Wang Bi granules in rheumatoid arthritis

Xu, Jia; Chen, Hong; Deng, Xiaofang; Jiao, Yuanyuan; Guo, Qiuyan; Zhang, Tong; Jiang, Hong; Xu, Haiyu; Wang, Ping; Liu, Changxiao

doi:10.1016/j.jpba.2021.114468

Cited by 2 publications

(3 citation statements)

References 27 publications

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“…Bi syndrome is caused by obstruction of the meridians of the limbs, and the clinical manifestations are mainly pain, soreness, numbness, stress, unfavourable flexion, and extension, or swelling and deformation of joints in muscles, joints, tendons, and bone (Xu et al. 2022 ). Qin Jiao has the properties of pungent, bitter and slightly cold, with indications of rheumatism, soothes tendons and collaterals, clears heat and dampness, and removes jaundice.…”

Section: Discussionmentioning

confidence: 99%

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Network pharmacology identification and in vivo validation of key pharmacological pathways of Qin Jiao for gout and arthritis

Yang,

Wang,

Ding

et al. 2023

Pharmaceutical Biology

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Context: Gout is a chronic disease that imposes a huge financial and health burden on patients, which might diminish quality of life. Qin Jiao, a perennial herb found in northwestern China and Japan, is commonly used for treating various ailments. Objective: This study investigates the effects of Qin Jiao on gout and joint inflammation and elucidates its potential mechanism for gouty arthritis. Materials and methods: Study 1, a literature review was conducted using PubMed, Web of Science, and CNKI to assess the applications of Qin Jiao in arthritis treatment. Study 2 was performed to discover the component targets and gouty disease targets via TCMSP, OMIM, GeneCards and DRUGBANK, and network pharmacology analysis. Study 3, male Sprague-Dawley (SD) rats were divided into normal, model, colchicine, Qin Jiao low-dose (QJL), and Qin Jiao high-dose group (QJH), oral gavage for 40 d. Serum, synovial fluid, and synovial membrane tissue were collected to measure the expression levels of IL-1β, IL-6, and STAT3. Results: The research also identified potential targets and pharmacological pathways of Qin Jiao for gout treatment. In vivo study demonstrated Qin Jiao can reduce IL-1β levels in serum and ankle flushing fluid. ELISA analysis confirmed that Qin Jiao significantly reduces the protein expression of IL-6 and STAT3. Discussion and conclusion: Qin Jiao exerts anti-inflammatory effects on gouty arthritis by modulating the IL-6/STAT3 pathway. This study provides a biological basis for the use of Qin Jiao in treating arthritis-related diseases and offers experimental evidence for potential future drug development.

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Section: Discussionmentioning

confidence: 99%

“…Qin Jiao is always used to treat Bi syndrome , commonly referred to as rheumatic arthritis, rheumatoid arthritis, muscular spasms, joint pain, stroke, hemiplegia, facial distortion, numbness of limbs, proliferative arthritis, and spinal osteoarthritis, as well (Xu et al. 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Network pharmacology identification and in vivo validation of key pharmacological pathways of Qin Jiao for gout and arthritis

Yang,

Wang,

Ding

et al. 2023

Pharmaceutical Biology

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“…To further understand these targets, the Metascape data platform ( https://metascape.org/ ) was used to perform KEGG pathway enrichment analysis. KEGG enrichment bubble plots were then plotted by Microbiology online platform ( http://www.bioinformatics.com.cn/ ) ( 29 ).…”

Section: Methodsmentioning

confidence: 99%

UPLC-MS/MS profiling, antioxidant and anti-inflammatory activities, and potential health benefits prediction of phenolic compounds in hazel leaf

Zhao

Wang

et al. 2023

Front. Nutr.

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Hazel leaf, one of the by-products of hazelnut, which is widely used in traditional folk medicine around the world. In the present study, the profile of free, conjugated, and bound phenolic compounds from hazel leaf was detected and their antioxidant and anti-inflammatory activities were investigated. The potential health benefits of different phenolic compounds were also predicted. The results showed that the 35 phenolic substances of free, conjugated and bound forms were identified including phenolic acids, flavonoids and catechins. Most of the hazel leaf phenolics were presented in free form, followed by conjugated and bound form. All the fractions effectively inhibited the production of reactive oxygen species and malondialdehyde in TBHP-stimulated human umbilical vein endothelial cells by enhancing endogenous superoxide dismutase, and accordingly alleviated inflammatory cytokines (NO, IL-1β, TNF-α, and IL-6) in LPS-stimulated RAW264.7 cells, showing obvious antioxidant and anti-inflammatory capacity. Moreover, combined with network pharmacology, the potential therapeutic effects and functional pathways of hazel leaf phenolics were predicted, which provided value basis for exploring their treatment on diseases and developing health products in the future.

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Integrative pharmacology powers the detection of active components and mechanism underlying Wang Bi granules in rheumatoid arthritis

Cited by 2 publications

References 27 publications

Network pharmacology identification and in vivo validation of key pharmacological pathways of Qin Jiao for gout and arthritis

Network pharmacology identification and in vivo validation of key pharmacological pathways of Qin Jiao for gout and arthritis

UPLC-MS/MS profiling, antioxidant and anti-inflammatory activities, and potential health benefits prediction of phenolic compounds in hazel leaf

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