Integrin αvβ3-targeted polydopamine-coated gold nanostars for photothermal ablation therapy of hepatocellular carcinoma

Yang, Li; Hu, Ping; Wang, Xiali; Hou, Xu; Liu, Fengzhen; Jiang, Xiaohong

doi:10.1093/rb/rbab046

Cited by 26 publications

(13 citation statements)

References 52 publications

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“…16 GRGDSP is a highly biologically active RGD sequence that can bind to multiple integrins. [17][18] According to Jin et al, GRGDSP adsorbed on hyaluronic acid (HA) significantly boosted the adhesion and proliferation of gingival fibroblasts on the surface of the material. 19 Oxidized sodium alginate linked GRGDSP can form a biologically active interface after binding to collagen, which promotes cell migration and vascularization.…”

Section: Introductionmentioning

confidence: 99%

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A study of the role of multiple layer‐by‐layer assembled bionic extracellular matrix in promoting wound healing via activation of the Wnt signaling pathway

et al. 2023

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Wound healing is a multicellular collaborative process in which the adhesion and proliferation of fibroblasts in the wound is the basis for ensuring rapid wound healing, and in this process, it can promote the regeneration and remodeling of tissue and extracellular matrix. Studies have shown that Arg-Gly-Asp adhesive peptide (RGD) and basic fibroblast growth factor (bFGF) can stimulate the adhesion and proliferation of fibroblasts by activating the Wnt/β-catenin signaling pathway, respectively. This study adopts the principle of layer-by-layer self-assembly, and the binding force formed by electrostatic attraction and Schiff base was used to combine bFGF and RGD with collagen membrane to form a biomimetic membrane that is non-cytotoxic with strong biocompatibility that could promote soft tissue healing. The surface characteristics of MLCM and the sustained release concentration of bFGF in vitro were measured, and the effects of MLCM on cell viability, proliferation, migration, and wound healing by means of Wnt/catenin pathways were studied through cell experiments and animal experiments under the comparison of negative control groups and positive control groups. The results showed that MLCM could stimulate wound healing more actively and had a positive effect on cell activity, proliferation, and migration. During wound healing, MLCM activates the Wnt/β-catenin signaling pathway and inhibition of Wnt/β-catenin signaling pathway significantly reduces the positive effects of MLCM on wound healing.

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Section: Introductionmentioning

confidence: 99%

“…Sodium alginate itself is a common drug carrier 16 . GRGDSP is a highly biologically active RGD sequence that can bind to multiple integrins 17–18 . According to Jin et al, GRGDSP adsorbed on hyaluronic acid (HA) significantly boosted the adhesion and proliferation of gingival fibroblasts on the surface of the material 19 .…”

Section: Introductionmentioning

confidence: 99%

A study of the role of multiple layer‐by‐layer assembled bionic extracellular matrix in promoting wound healing via activation of the Wnt signaling pathway

et al. 2023

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“…It will be interesting to compare toxicity profiles for this approach with those of liposomal encapsulations. Lastly, RGD peptides have also been incorporated in polydopamine (PDA) coatings to target photosensitizing agents such as gold nanostars leading to tumor specific cell death and limited adverse effects after near infrared activation of the drug ( Li Y. et al, 2021 ) ( Figure 3C ).…”

Section: Integrin Mediated Drug Deliverymentioning

confidence: 99%

Targeting Integrins for Cancer Therapy - Disappointments and Opportunities

Bergonzini

Kroese

Zweemer

et al. 2022

Front. Cell Dev. Biol.

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Integrins mediate adhesive interactions between cells and their environment, including neighboring cells and extracellular matrix (ECM). These heterodimeric transmembrane receptors bind extracellular ligands with their globular head domains and connect to the cytoskeleton through multi-protein interactions at their cytoplasmic tails. Integrin containing cell–matrix adhesions are dynamic force-responsive protein complexes that allow bidirectional mechanical coupling of cells with their environment. This allows cells to sense and modulate tissue mechanics and regulates intracellular signaling impacting on cell faith, survival, proliferation, and differentiation programs. Dysregulation of these functions has been extensively reported in cancer and associated with tumor growth, invasion, angiogenesis, metastasis, and therapy resistance. This central role in multiple hallmarks of cancer and their localization on the cell surface makes integrins attractive targets for cancer therapy. However, despite a wealth of highly encouraging preclinical data, targeting integrin adhesion complexes in clinical trials has thus far failed to meet expectations. Contributing factors to therapeutic failure are 1) variable integrin expression, 2) redundancy in integrin function, 3) distinct roles of integrins at various disease stages, and 4) sequestering of therapeutics by integrin-containing tumor-derived extracellular vesicles. Despite disappointing clinical results, new promising approaches are being investigated that highlight the potential of integrins as targets or prognostic biomarkers. Improvement of therapeutic delivery at the tumor site via integrin binding ligands is emerging as another successful approach that may enhance both efficacy and safety of conventional therapeutics. In this review we provide an overview of recent encouraging preclinical findings, we discuss the apparent disagreement between preclinical and clinical results, and we consider new opportunities to exploit the potential of integrin adhesion complexes as targets for cancer therapy.

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“…To enhance the tumor-targeting ability of IALP-Cs, we systematically investigated the factors that affect liposomes uptake by A549 cells through modification of ALPs with three different peptides, RGD (Arg-Gly-Asp), TAT 48–60 (GRKKRRQRRRPPQ) and RR 9 (RGDRRRRRRRRRC). RGD peptide can be specifically targeted α v β 3 highly expressed endothelial cells of tumor vasculature and TAT 48–60 peptide is known as a cell membrane penetrating peptide because of its large number of positive charges [ 26 – 28 ]. RR 9 peptide is synthesized from a stretch of positively charged arginine chains with RGD peptide, which integrates the functions of both peptides [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Transmissible H-aggregated NIR-II fluorophore to the tumor cell membrane for enhanced PTT and synergistic therapy of cancer

Wang

Chen

et al. 2023

Nano Convergence

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Photothermal therapy (PTT) combined with second near-infrared (NIR-II) fluorescence imaging (FI) has received increasing attention owing to its capacity for precise diagnosis and real-time monitoring of the therapeutic effects. It is of great clinical value to study organic small molecular fluorophores with both PTT and NIR-II FI functions. In this work, we report a skillfully fluorescent lipid nanosystem, the RR9 (RGDRRRRRRRRRC) peptide-coated anionic liposome loaded with organic NIR-II fluorophore IR-1061 and chemotherapeutic drug carboplatin, which is named RRIALP-C4. According to the structural interaction between IR-1061 and phospholipid bilayer demonstrated by molecular dynamics simulations, IR-1061 is rationally designed to possess the H-aggregated state versus the free state, thus rendering RRIALP-C4 with the activated dual-channel integrated function of intravital NIR-II FI and NIR-I PTT. Functionalization of RRIALP-C4 with RR9 peptide endows the specifically targeting capacity for αvβ3-overexpressed tumor cells and, more importantly, allows IR-1061 to transfer the H-aggregated state from liposomes to the tumor cell membrane through enhanced membrane fusion, thereby maintaining its PTT effect in tumor tissues. In vivo experiments demonstrate that RRIALP-C4 can effectively visualize tumor tissues and systemic blood vessels with a high sign-to-background ratio (SBR) to realize the synergistic treatment of thermochemotherapy by PTT synergistically with temperature-sensitive drug release. Therefore, the strategy of enhanced PTT through H-aggregation of NIR-II fluorophore in the tumor cell membrane has great potential for developing lipid nanosystems with integrated diagnosis and treatment function.

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Integrin αvβ3-targeted polydopamine-coated gold nanostars for photothermal ablation therapy of hepatocellular carcinoma

Cited by 26 publications

References 52 publications

A study of the role of multiple layer‐by‐layer assembled bionic extracellular matrix in promoting wound healing via activation of the Wnt signaling pathway

A study of the role of multiple layer‐by‐layer assembled bionic extracellular matrix in promoting wound healing via activation of the Wnt signaling pathway

Targeting Integrins for Cancer Therapy - Disappointments and Opportunities

Transmissible H-aggregated NIR-II fluorophore to the tumor cell membrane for enhanced PTT and synergistic therapy of cancer

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