Intellectual Impairment With Localized Cerebral Lesions

McFie, John; Pjercy, M. F.

doi:10.1093/brain/75.3.292

Cited by 95 publications

(30 citation statements)

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“…The difference in scores between patients with right and left hemiplegia is in agreement with the observations of McFie and Piercy (1952) that impairment of performance on verbal intelligence tests was greater in patients with lesions of the dominant hemisphere, even in the absence of dysphasia, than in those with lesions of the non-dominant hemisphere. At the same time impaired retention depended, in the opinion of these authors, on the magnitude of the lesion rather than on its location.…”

Section: Relationship To Prognosissupporting

confidence: 90%

A Preliminary Evaluation of a Paired-Associate Verbal Learning Test in Geriatric Practice

Isaacs¹

1962

Geront clin

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Section: Relationship To Prognosissupporting

confidence: 90%

A Preliminary Evaluation of a Paired-Associate Verbal Learning Test in Geriatric Practice

Isaacs¹

1962

Geront clin

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“…With respect to laterality, greater impairment on the Bender Gestalt test after right thalamic lesions is consistent with the findings for cortical lesions (McFie, Piercy, and Zangwill, 1950;McFie and Piercy, 1952;and Reitan, 1955, among others). There were no significant lateralization differences for any of the other tests, thus agreeing with the findings of Riklan and Levita (1969).…”

Section: Discussionsupporting

confidence: 86%

Psychological changes correlated with thalamotomy site

Jurko

Andy

1973

Journal of Neurology, Neurosurgery & Psychiatry

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SUMMARY The effects of surgically placed thalamic lesions on cognitive skills, as measured by psychological tests, are dependent upon the nature of the skill and the site of the lesion. Lesions within the limits of the centrum medianum nucleus produce few deficits, whereas lesions outside its limits result in deficits for a greater number of skills. In general, the more complex skills revealed more impairment and the deficits were long lasting.The function of the thalamus in relation to cognition, as reflected by psychological tests, was evaluated in patients treated by thalamotomy for Parkinsonism, seizure, and pain disorders.The psychological tests are considered under four categories and correlated with lesions placed within and outside the limits of the centrum medianum nucleus. The age of patients with Parkinson's disease ranged from 37 to 72 years and those with seizure and pain disorders from 20 to 62 years. METHOD SURGICAL PROCEDURE Lytic lesions were made stereotaxically under local anaesthesia. A 20 gauge barrel electrode with a 3 to 4 mm non-insulated tip was inserted into the diencephalon through a frontal burr hole at an angle of approximately 40 to 45°. Electrical stimulation followed by an electrolytic lesion was performed as previously described (Andy, Jurko, and Sias, 1963;Andy, 1966 TEST RESULTS AND LESION SITE The data were analysed by plotting results derived from each of the tests in relation to the locus of the lesion. Scattergrams were used for plotting the lesions on horizontal planes through the thalamus at the level of the centrum medianum nucleus (+ 3-5 mm). This plane was chosen because the maximum size of the lesion was at that approximate location of the thalamus, and the greater variability in these patients was in relation to the mediolateral and frontoposterior positioning of the lesion. The statistics used, where applicable, were the 2 x 2 x2 test, and the two-tailed binomial expansion test. RESULTS

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“…Poorer performances in nine of 12 measures (with only slight differences in the remaining three) were shown by eight patients with left frontal tumours compared with nine with right frontal tumours in one study (McFie and Piercy, 1952a). In a second study, McFie and Piercy (1952b) reported that failures in Weigl sorting tests in 74 patients were significantly greater in patients with dominant hemisphere lesions.…”

Section: Discussionmentioning

confidence: 93%

Intellectual functions in patients with lateralized frontal tumours.

Smith¹

1966

Journal of Neurology, Neurosurgery & Psychiatry

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Intellectual Impairment With Localized Cerebral Lesions

Cited by 95 publications

References 0 publications

A Preliminary Evaluation of a Paired-Associate Verbal Learning Test in Geriatric Practice

A Preliminary Evaluation of a Paired-Associate Verbal Learning Test in Geriatric Practice

Psychological changes correlated with thalamotomy site

Intellectual functions in patients with lateralized frontal tumours.

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