Intellectual Level Measured by Army Classification Battery and Serum Uric Acid Concentration

Stetten, DeWitt; Hearon, John Z.

doi:10.1126/science.129.3365.1737

Cited by 80 publications

(26 citation statements)

References 3 publications

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“…Earlier studies reported a positive correlation between UA levels and cognitive performance estimated in adult persons using the IQ. However, these studies suffered from several methodological limitations such as the small sample size, the lack of information about confounders, and the limited neuropsychological evaluation [32,33] .…”

Section: Discussionmentioning

confidence: 99%

Uric Acid and Dementia in Community-Dwelling Older Persons

Ruggiero

Cherubini

Lauretani

et al. 2009

Dement Geriatr Cogn Disord

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Background: The biological action of uric acid (UA) in humans is controversial. UA is considered an antioxidant compound, but preclinical evidence suggests a proinflammatory action. Epidemiological studies found that hyperuricemia is associated with conditions leading to dementia. Our aim is to investigate the relationship between UA levels and dementia in older persons. Methods: Cross-sectional study performed in 1,016 community-dwelling older persons participating in the InCHIANTI study. Participants underwent determination of circulating UA levels and neuropsychological evaluation. A multivariate logistic regression model was used to estimate the probability of participants belonging to the highest and middle UA tertile to be affected by dementia compared to those in the lowest tertile. Results: Demented persons had higher UA levels (p = 0.001) and the prevalence of persons affected by dementia increased across UA tertiles (p < 0.0001). Independent of several confounders, persons belonging to the highest UA tertile had a threefold (OR = 3.32; 95% CI: 1.06–10.42) higher probability to suffer from a dementia syndrome while those in the middle UA tertile tended to have a higher probability of being demented compared to those in the lowest tertile. Conclusion: In a population-based sample, high circulating UA levels are associated with an increased likelihood to be affected by a dementia syndrome.

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Section: Discussionmentioning

confidence: 99%

Uric Acid and Dementia in Community-Dwelling Older Persons

Ruggiero

Cherubini

Lauretani

et al. 2009

Dement Geriatr Cogn Disord

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“…Plasma, serum or urine uric acid level is also reported to be associated with intellectual performance (Stetten and Hearon, 1959;Dunn et al, 1963) and behavior variables (Brooks and Mueller, 1966). It is thus suggested that there might be an association between uric acid level in body fluids and behavioral characteristics due to genetic origin, since there are accumulated evidences that some behavioral characteristics including activity (e.g.…”

Section: Introductionmentioning

confidence: 99%

Plasma and urine uric acid levels: Heritability estimates and correlation with IQ

1980

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SummaryPlasma and urine uric acid levels were measured in 37 pairs of twins aged 11 or 12 years and their parents. Effect of age differed between sexes and between plasma and urine. Assuming linear regression on age, the uric acid levels were adjusted for a fixed age, then standardized with mean 0 and standard deviation 1. The standardized values for plasma yielded a high MZ twin correlation (0.8429), a high mid-parent-offspring regression (0.7516) and a high parent-offspring regression (0.5100). Because of a high husband-wife correlation (0.3771) a model was used for estimating parameters, where effects of assortative mating and/or common within-family environment were incorporated. In plasma two sets of estimates were obtained: VA/Vp=0.7064, 0.3251; VD/Vp=0.1010, 0.1769; and VEC (variance due to common within-family environment)/Vp=0.0362, 0.3416. In urine VA/Vt,=0.4125, Vo/Vp=0.3556 and VEc/Vp=--0.1106. It was concluded that heritability of uric acid level was not less than 0.3 in plasma and not less than 0.4 in urine. The plasma uric acid level and IQ was positively correlated (between 0.17 and 0.34), but not significant.

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“…This hypothesis has not been confirmed. OCTOBER Clinical studies have suggested a relationship between intelligence and hyperuricemia in army inductees, 23 and higher levels of uric acid have been found in executives than in craftsmen. 24 Brooks and Mueller 211 found drive, achievement and leadership in association with hyperuricemia in professors.…”

Section: Goutmentioning

confidence: 98%

Occult Mood in Musculoskeletal Diseases

Ward

1970

Postgraduate Medicine

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Intellectual Level Measured by Army Classification Battery and Serum Uric Acid Concentration

Cited by 80 publications

References 3 publications

Uric Acid and Dementia in Community-Dwelling Older Persons

Uric Acid and Dementia in Community-Dwelling Older Persons

Plasma and urine uric acid levels: Heritability estimates and correlation with IQ

Occult Mood in Musculoskeletal Diseases

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