1980
DOI: 10.1007/bf01997695
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Plasma and urine uric acid levels: Heritability estimates and correlation with IQ

Abstract: SummaryPlasma and urine uric acid levels were measured in 37 pairs of twins aged 11 or 12 years and their parents. Effect of age differed between sexes and between plasma and urine. Assuming linear regression on age, the uric acid levels were adjusted for a fixed age, then standardized with mean 0 and standard deviation 1. The standardized values for plasma yielded a high MZ twin correlation (0.8429), a high mid-parent-offspring regression (0.7516) and a high parent-offspring regression (0.5100). Because of a … Show more

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Cited by 12 publications
(10 citation statements)
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“…Furthermore, a longitudinal study, using data from the Invecchiare in Chianti (InCHIANTI) study, has found that higher circulating levels of UA are prospectively associated with better muscle function in older adults . Finally, despite the failure of previous investigations to prove UA induces “an intelligence and excellence of all‐round performance” because of small sample sizes and inconsistent findings between cohorts, a large, population‐based cohort study suggested that higher levels of UA were associated with a decreased risk of dementia and better global cognitive function, executive function and memory function after adjustment for several cardiovascular risk factors . In order to establish the reported association across populations, we carried out a replication study in Chinese aged 50–74 years to test the relationship between circulating levels of UA and muscle strength, as well as global cognitive function.…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, a longitudinal study, using data from the Invecchiare in Chianti (InCHIANTI) study, has found that higher circulating levels of UA are prospectively associated with better muscle function in older adults . Finally, despite the failure of previous investigations to prove UA induces “an intelligence and excellence of all‐round performance” because of small sample sizes and inconsistent findings between cohorts, a large, population‐based cohort study suggested that higher levels of UA were associated with a decreased risk of dementia and better global cognitive function, executive function and memory function after adjustment for several cardiovascular risk factors . In order to establish the reported association across populations, we carried out a replication study in Chinese aged 50–74 years to test the relationship between circulating levels of UA and muscle strength, as well as global cognitive function.…”
Section: Introductionmentioning
confidence: 99%
“…It deals with the heritability of the blood concentration of uric acid and with the correlation of the latter with IQ. The study was conducted several years ago [8,15] and the data were reanalysed recently.…”
Section: Introductionmentioning
confidence: 99%
“…Our report also supports two smaller studies. One study observed a positive, non-significant correlation between plasma uric acid level and IQ (12), and another study found a positive association between serum uric acid levels and a spatial ability test (mental rotations test) and educational achievement, but this became non-significant on adjusting for height and weight (13).…”
Section: Discussionmentioning
confidence: 99%
“…Recently, a large study in 1724 participants (age 55 or older) showed that higher uric acid levels were associated with better global cognitive function, executive function and memory function after correcting for cardiovascular risk factors (10). Previous investigations have also proposed the importance of serum uric acid inducing 'an intelligence and excellence of all-round performance' but were not definitive studies, hampered by small sample sizes and inconsistent findings between cohorts (11)(12)(13). However, the direction of this effect is not conclusive as other studies show the opposite trend that higher uric acid levels is associated with poorer cognitive ability.…”
Section: Introductionmentioning
confidence: 99%