With the help of fractional differential equations, this article studies the failure morphology, fatigue strength, and fatigue life of corroded reinforced concrete beams under fatigue loading. Studies have shown that the mid-span deflection of low-corrosion reinforced concrete beams is smaller than that of uncorroded reinforced concrete beams. The corrosion-fatigue coupling effect accelerates the fatigue crack growth rate of steel bars. This reduces the fatigue modulus of concrete and causes the stiffness of the beam to degrade. The research results provide a theoretical basis for the fatigue performance evaluation of corroded reinforced concrete beams.