-In this paper, a sampled-data observer-based decentralized fuzzy control technique is proposed for a class of nonlinear large-scale systems, which can be represented to a Takagi-Sugeno fuzzy system. The premise variable is assumed to be measurable for the design of the observer-based fuzzy controller, and the closed-loop system is obtained. Based on an exact discretized model of the closed-loop system, the stability condition is derived for the closed-loop system. Also, the stability condition is converted into the linear matrix inequality (LMI) format. Finally, an example is provided to verify the effectiveness of the proposed techniques.