“Intelligent” Fingerprinting: Simultaneous Identification of Drug Metabolites and Individuals by Using Antibody‐Functionalized Nanoparticles

Leggett, Richard M.; Lee-Smith, E; Jickells, Sue M.; Russell, David A.

doi:10.1002/anie.200700217

Cited by 216 publications

(150 citation statements)

References 12 publications

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“…Characteristic compounds may be found in a latent fingerprint which could potentially be exploited to provide donor information such as age or a personal habit [4,5,31]. The individual amino acid and fatty acid composition data were studied to determine whether any quantitative variation arose as a consequence of a particular donor attribute, namely gender, diet, age and smoking.…”

Section: Individual Variation and Personal Traitsmentioning

confidence: 99%

“…A variety of strategies are employed in the development of new latent fingerprint enhancement techniques such as the exploitation of chemical analogues of existing reagents or the application of reagents used in other fields [2,3]. A further strategy involves the targeting of specific compounds in latent fingerprint residue, for example the detection of drug metabolites using antibodies immobilised on nanoparticles or the immunodetection of peptides and proteins [4,5,6]. In some instances these enhancement techniques may provide information about personal habits, as well as develop ridge detail [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…A further strategy involves the targeting of specific compounds in latent fingerprint residue, for example the detection of drug metabolites using antibodies immobilised on nanoparticles or the immunodetection of peptides and proteins [4,5,6]. In some instances these enhancement techniques may provide information about personal habits, as well as develop ridge detail [4,5]. Novel applications of analytical techniques, including micro-X-ray fluorescence, Fourier transform infrared spectroscopy and time-of-flight secondary ion mass spectrometry are also being used in the visualisation of latent fingerprints and to study their behaviour [7,8,9,10].…”

Section: Introductionmentioning

confidence: 99%

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Variation in amino acid and lipid composition of latent fingerprints

Croxton

Baron

Butler

et al. 2010

Forensic Science International

200

210

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The enhancement of latent fingerprints, both at the crime scene and in the laboratory using an array of chemical, physical and optical techniques, permits their use for identification. Despite the plethora of techniques available, there are occasions when latent fingerprints are not successfully enhanced. An understanding of latent fingerprint chemistry and behaviour will aid the improvement of current techniques and the development of novel ones. In this study the amino acid and fatty acid content of 'real' latent fingerprints collected on a non-porous surface was analysed by gas chromatography-mass spectrometry.Squalene was also quantified in addition. Hexadecanoic acid, octadecanoic acid and cis-9-octadecenoic acid were the most abundant fatty acids in all samples. There was, however, wide variation in the relative amounts of each fatty acid in each sample. It was clearly demonstrated that touching sebum-rich areas of the face immediately prior to fingerprint deposition resulted in a significant increase in the amount of fatty acids and squalene deposited in the resulting 'groomed' fingerprints. Serine was the most abundant amino acid identified followed by glycine, alanine and aspartic acid. The significant quantitative differences between the 'natural' and 'groomed' fingerprint samples seen for fatty acids were not observed in the case of the amino acids. This study demonstrates the variation in latent fingerprint composition between individuals and the impact of the sampling protocol on the quantitative analysis of fingerprints.

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Section: Individual Variation and Personal Traitsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Variation in amino acid and lipid composition of latent fingerprints

Croxton

Baron

Butler

et al. 2010

Forensic Science International

200

210

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show abstract

“…B. (Na 48 24 ]·0.5 DME inzwischen auch ein Zugang zu "molekularen" Legierungen. [288] Im Hinblick auf ihre Eigenschaften zeigen insbesondere Clustermoleküle der Übergangsmetallchalkogenide ein Verhalten, das demjenigen der Quantenpunkte entspricht (vgl.…”

Section: Veredlung Von Bulkwerkstoffenunclassified

Nanopartikuläre Funktionsmaterialien

2010

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Nanopartikuläre Funktionsmaterialien bieten vielfältige Perspektiven für die fortschreitende Miniaturisierung und die zunehmende Komplexität der technischen Entwicklung. Ebenso tragen Nanopartikel maßgeblich zum ressourcenschonenden Einsatz von Stoffen bei. Neben diesen naheliegenden Aspekten beruht die Bedeutung der Nanopartikel jedoch auf ihren grundsätzlich neuartigen Eigenschaften und Funktionen. Diese reichen von photonischen Kristallen und effizienten Leuchtstoffen, Einzelpartikeln und Dünnschichten für elektronische Speicher und Schaltelemente, magnetischen Flüssigkeiten und hochselektiven Katalysatoren, vielfältigen Möglichkeiten zur Veredlung von Oberflächen, neuartigen Materialien und Konzepten zur Energieumwandlung und ‐speicherung, Kontrastmitteln für die molekularbiologische und medizinische Diagnostik bis hin zu grundsätzlich neuartigen Materialformen und ‐strukturen wie Nanocontainern und Superkristallen. Die Realisierung hochwertiger Nanopartikel erfordert dabei bereits während der Materialsynthese die Berücksichtigung vieler Einflussgrößen, die Partikelkern, Partikeloberflächen, kolloidale Eigenschaften und Partikelabscheidung betreffen. Eine sinnvolle Eigenschaftscharakterisierung und ‐bewertung bedingt dabei die Einbindung vielfältiger Kompetenzen aus unterschiedlichsten Fachgebieten. Dieses Umfeld macht insgesamt Anspruch als auch Reiz für den “Nanowissenschaftler” aus.

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“…The classical approach is to apply a powder (either dry or as a suspension) that adheres physically to the sweat residues; the powder may be uorescent, 16- 32 In some cases the interaction of the reagent may be relatively unspecic (physical adhesion of powders), in others it may involve moderately specic chemistry (CdS binding with fatty acids and amino acids generally found in ngerprint deposits) and in other cases it may be very specic (reaction with secreted drug metabolites of antibody-functionalised nanoparticles. 33 However, the common factor is that the reagent interacts with the deposited residue. This makes all these technologies vulnerable to loss or deterioration of ngerprint residue, e.g.…”

mentioning

confidence: 99%

Nanoscale control of interfacial processes for latent fingerprint enhancement

et al. 2013

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Latent fingerprints on metal surfaces may be visualized by exploiting the insulating characteristics of the fingerprint deposit as a "mask" to direct electrodeposition of an electroactive polymer to the bare metal between the fingerprint ridges. This approach is complementary to most latent fingerprint enhancement methods, which involve physical or chemical interaction with the fingerprint residue. It has the advantages of sensitivity (a nanoscale residue can block electron transfer) and, using a suitable polymer, optimization of visual contrast. This study extends the concept in two significant respects. First, it explores the feasibility of combining observation based on optical absorption with observation based on fluorescence. Second, it extends the methodology to materials (here, polypyrrole) that may undergo postdeposition substitution chemistry, here binding of a fluorophore whose size and geometry preclude direct polymerization of the functionalised monomer. The scenario involves a lateral spatial image (the whole fingerprint, first level detail) at the centimetre scale, with identification features (minutiae, second level detail) at the 100-200 mm scale and finer features (third level detail) at the 10-50 mm scale.However, the strategy used requires vertical spatial control of the (electro)chemistry at the 10-100 nm scale. We show that this can be accomplished by polymerization of pyrrole functionalised with a good leaving group, ester-bound FMOC, which can be hydrolysed and eluted from the deposited polymer to generate solvent "voids".Overall the "void" volume and the resulting effect on polymer dynamics facilitate entry and amide bonding of Dylight 649 NHS ester, a large fluorophore. FTIR spectra demonstrate the spatially integrated compositional changes. Both the hydrolysis and fluorophore functionalization were followed using neutron reflectivity to determine vertical spatial composition variations, which control image development in the lateral direction.

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“Intelligent” Fingerprinting: Simultaneous Identification of Drug Metabolites and Individuals by Using Antibody‐Functionalized Nanoparticles

Cited by 216 publications

References 12 publications

Variation in amino acid and lipid composition of latent fingerprints

Variation in amino acid and lipid composition of latent fingerprints

Nanopartikuläre Funktionsmaterialien

Nanoscale control of interfacial processes for latent fingerprint enhancement

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